GB1240625A - Analgesic compositions - Google Patents
Analgesic compositionsInfo
- Publication number
- GB1240625A GB1240625A GB40642/69A GB4064269A GB1240625A GB 1240625 A GB1240625 A GB 1240625A GB 40642/69 A GB40642/69 A GB 40642/69A GB 4064269 A GB4064269 A GB 4064269A GB 1240625 A GB1240625 A GB 1240625A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- hydrogen
- compositions
- ethyl
- emulsions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,240,625. Analgesic compositions. ELI LILLY & CO. 14 Aug., 1969 [15 Aug., 1968 (2)], No. 40642/69. Heading A5B. Analgesic compositions comprise (i) a 3- or 4-phenoxyphenylalkanoic acid of the formula: or a pharmaceutically acceptable salt thereof, wherein (a) the phenoxy moiety is in the 3- position and R<SP>3</SP> is methyl or ethyl and R<SP>4</SP> is hydrogen, or (b) the phenoxy moiety is in the 4-position, R<SP>3</SP> is hydrogen or methyl and when R<SP>3</SP> is hydrogen R<SP>4</SP> is hydrogen, fluoro, ethyl, methyl or methoxy and when R<SP>3</SP> is methyl R<SP>4</SP> is hydrogen, and (ii) an ester of 1, 2-diphenyl-2-hydroxy-3-methyl-4-(substituted) aminobutane or a pharmaceutically acceptable salt thereof having the formula: wherein R 1 is methyl or ethyl and R 2 is dimethylamino or pyrrolidino. The composition preferably contains α-d-propoxyphene napsylate or hydrochloride and 2-(3-[or 4]-phenoxyphenyl) propionic acid. The phenoxyphenyl compound may be in the form of the Na, K, Ca, Mg, ammonium or benzylammonium salts and α-d-propoxyphene may be in the form of its hydrochloride, hydrobromide, sulphate, bisulphate, acetate, valerate, oleate, phenate, laurate, borate, benzoate, lactate, phosphate, tosylate, citrate, maleate, fumarate, succinate, tartrate or napsylate. The compositions may be administered orally as tablets, pills, powders, granules, capsules, emulsions, solutions, suspensions, syrups or elixirs; parenterally in the form of sterile aqueous or non-aqueous solutions, suspensions or emulsions; or rectally as suppositories. The compositions may contain additional active ingredients such as acetyl salicylic acid.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75278668A | 1968-08-15 | 1968-08-15 | |
US75278468A | 1968-08-15 | 1968-08-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1240625A true GB1240625A (en) | 1971-07-28 |
Family
ID=27115644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB40642/69A Expired GB1240625A (en) | 1968-08-15 | 1969-08-14 | Analgesic compositions |
Country Status (10)
Country | Link |
---|---|
BE (1) | BE737416A (en) |
CA (1) | CA942669A (en) |
DE (1) | DE1941584A1 (en) |
FR (1) | FR2015727B1 (en) |
GB (1) | GB1240625A (en) |
IE (1) | IE33542B1 (en) |
IL (1) | IL32782A (en) |
LU (1) | LU59282A1 (en) |
NL (1) | NL150335B (en) |
SE (1) | SE360014B (en) |
-
1969
- 1969-07-31 IE IE1065/69A patent/IE33542B1/en unknown
- 1969-08-05 IL IL32782A patent/IL32782A/en unknown
- 1969-08-12 SE SE11176/69A patent/SE360014B/xx unknown
- 1969-08-13 LU LU59282D patent/LU59282A1/xx unknown
- 1969-08-13 BE BE737416D patent/BE737416A/xx unknown
- 1969-08-13 CA CA059,408A patent/CA942669A/en not_active Expired
- 1969-08-14 FR FR6928041A patent/FR2015727B1/fr not_active Expired
- 1969-08-14 GB GB40642/69A patent/GB1240625A/en not_active Expired
- 1969-08-15 NL NL696912501A patent/NL150335B/en unknown
- 1969-08-16 DE DE19691941584 patent/DE1941584A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
FR2015727A1 (en) | 1970-04-30 |
NL150335B (en) | 1976-08-16 |
BE737416A (en) | 1970-02-13 |
IL32782A0 (en) | 1969-12-31 |
LU59282A1 (en) | 1970-02-13 |
CA942669A (en) | 1974-02-26 |
IE33542L (en) | 1970-02-15 |
IL32782A (en) | 1974-01-14 |
DE1941584A1 (en) | 1970-08-27 |
FR2015727B1 (en) | 1974-02-01 |
IE33542B1 (en) | 1974-08-07 |
NL6912501A (en) | 1970-02-17 |
SE360014B (en) | 1973-09-17 |
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