GB1240625A - Analgesic compositions - Google Patents

Analgesic compositions

Info

Publication number
GB1240625A
GB1240625A GB40642/69A GB4064269A GB1240625A GB 1240625 A GB1240625 A GB 1240625A GB 40642/69 A GB40642/69 A GB 40642/69A GB 4064269 A GB4064269 A GB 4064269A GB 1240625 A GB1240625 A GB 1240625A
Authority
GB
United Kingdom
Prior art keywords
methyl
hydrogen
compositions
ethyl
emulsions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB40642/69A
Inventor
Joseph Alvin Miller Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB1240625A publication Critical patent/GB1240625A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,240,625. Analgesic compositions. ELI LILLY & CO. 14 Aug., 1969 [15 Aug., 1968 (2)], No. 40642/69. Heading A5B. Analgesic compositions comprise (i) a 3- or 4-phenoxyphenylalkanoic acid of the formula: or a pharmaceutically acceptable salt thereof, wherein (a) the phenoxy moiety is in the 3- position and R<SP>3</SP> is methyl or ethyl and R<SP>4</SP> is hydrogen, or (b) the phenoxy moiety is in the 4-position, R<SP>3</SP> is hydrogen or methyl and when R<SP>3</SP> is hydrogen R<SP>4</SP> is hydrogen, fluoro, ethyl, methyl or methoxy and when R<SP>3</SP> is methyl R<SP>4</SP> is hydrogen, and (ii) an ester of 1, 2-diphenyl-2-hydroxy-3-methyl-4-(substituted) aminobutane or a pharmaceutically acceptable salt thereof having the formula: wherein R 1 is methyl or ethyl and R 2 is dimethylamino or pyrrolidino. The composition preferably contains α-d-propoxyphene napsylate or hydrochloride and 2-(3-[or 4]-phenoxyphenyl) propionic acid. The phenoxyphenyl compound may be in the form of the Na, K, Ca, Mg, ammonium or benzylammonium salts and α-d-propoxyphene may be in the form of its hydrochloride, hydrobromide, sulphate, bisulphate, acetate, valerate, oleate, phenate, laurate, borate, benzoate, lactate, phosphate, tosylate, citrate, maleate, fumarate, succinate, tartrate or napsylate. The compositions may be administered orally as tablets, pills, powders, granules, capsules, emulsions, solutions, suspensions, syrups or elixirs; parenterally in the form of sterile aqueous or non-aqueous solutions, suspensions or emulsions; or rectally as suppositories. The compositions may contain additional active ingredients such as acetyl salicylic acid.
GB40642/69A 1968-08-15 1969-08-14 Analgesic compositions Expired GB1240625A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75278668A 1968-08-15 1968-08-15
US75278468A 1968-08-15 1968-08-15

Publications (1)

Publication Number Publication Date
GB1240625A true GB1240625A (en) 1971-07-28

Family

ID=27115644

Family Applications (1)

Application Number Title Priority Date Filing Date
GB40642/69A Expired GB1240625A (en) 1968-08-15 1969-08-14 Analgesic compositions

Country Status (10)

Country Link
BE (1) BE737416A (en)
CA (1) CA942669A (en)
DE (1) DE1941584A1 (en)
FR (1) FR2015727B1 (en)
GB (1) GB1240625A (en)
IE (1) IE33542B1 (en)
IL (1) IL32782A (en)
LU (1) LU59282A1 (en)
NL (1) NL150335B (en)
SE (1) SE360014B (en)

Also Published As

Publication number Publication date
FR2015727A1 (en) 1970-04-30
NL150335B (en) 1976-08-16
BE737416A (en) 1970-02-13
IL32782A0 (en) 1969-12-31
LU59282A1 (en) 1970-02-13
CA942669A (en) 1974-02-26
IE33542L (en) 1970-02-15
IL32782A (en) 1974-01-14
DE1941584A1 (en) 1970-08-27
FR2015727B1 (en) 1974-02-01
IE33542B1 (en) 1974-08-07
NL6912501A (en) 1970-02-17
SE360014B (en) 1973-09-17

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