GB1239989A - Resolution of (cis-1,2-epoxypropyl)phosphonic acid into its optically-active forms - Google Patents
Resolution of (cis-1,2-epoxypropyl)phosphonic acid into its optically-active formsInfo
- Publication number
- GB1239989A GB1239989A GB50638/68A GB5063868A GB1239989A GB 1239989 A GB1239989 A GB 1239989A GB 50638/68 A GB50638/68 A GB 50638/68A GB 5063868 A GB5063868 A GB 5063868A GB 1239989 A GB1239989 A GB 1239989A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salt
- optically active
- salts
- mixture
- diastereoisomeric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 abstract 17
- 239000002585 base Substances 0.000 abstract 8
- 239000000203 mixture Substances 0.000 abstract 6
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 5
- -1 alkaline earth metal salt Chemical class 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- RQEUFEKYXDPUSK-UHFFFAOYSA-N 1-phenylethylamine Chemical compound CC(N)C1=CC=CC=C1 RQEUFEKYXDPUSK-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical class CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 abstract 1
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 abstract 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 150000001361 allenes Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- RBFQJDQYXXHULB-UHFFFAOYSA-N arsane Chemical class [AsH3] RBFQJDQYXXHULB-UHFFFAOYSA-N 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 150000004074 biphenyls Chemical class 0.000 abstract 1
- 235000013877 carbamide Nutrition 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 abstract 1
- 150000001925 cycloalkenes Chemical class 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 abstract 1
- 150000002429 hydrazines Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 150000003003 phosphines Chemical class 0.000 abstract 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 abstract 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- OUULRIDHGPHMNQ-UHFFFAOYSA-N stibane Chemical class [SbH3] OUULRIDHGPHMNQ-UHFFFAOYSA-N 0.000 abstract 1
- HISNRBVYBOVKMB-UHFFFAOYSA-N stibonium Chemical compound [SbH4+] HISNRBVYBOVKMB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/14—Esters of phosphoric acids containing P(=O)-halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/14—Esters of phosphoric acids containing P(=O)-halide groups
- C07F9/1403—Esters of phosphoric acids containing P(=O)-halide groups containing the structure Hal-P(=O)-O-unsaturated acyclic group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67920367A | 1967-10-30 | 1967-10-30 | |
| US72944568A | 1968-05-15 | 1968-05-15 | |
| US75385868A | 1968-08-20 | 1968-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1239989A true GB1239989A (en) | 1971-07-21 |
Family
ID=27418346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB50638/68A Expired GB1239989A (en) | 1967-10-30 | 1968-10-24 | Resolution of (cis-1,2-epoxypropyl)phosphonic acid into its optically-active forms |
Country Status (17)
| Country | Link |
|---|---|
| BE (1) | BE723073A (fr) |
| CH (1) | CH527224A (fr) |
| DE (1) | DE1805681C3 (fr) |
| DK (1) | DK139141B (fr) |
| ES (1) | ES359542A1 (fr) |
| FI (1) | FI51703C (fr) |
| FR (1) | FR1592150A (fr) |
| GB (1) | GB1239989A (fr) |
| IE (1) | IE32997B1 (fr) |
| IL (1) | IL30920A (fr) |
| IT (1) | IT986758B (fr) |
| LU (1) | LU57184A1 (fr) |
| NL (1) | NL6814979A (fr) |
| NO (1) | NO132992C (fr) |
| OA (1) | OA03882A (fr) |
| RO (1) | RO54819A (fr) |
| SE (1) | SE377941B (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109369718A (zh) * | 2018-12-07 | 2019-02-22 | 武汉工程大学 | 一种左磷右铵盐的制备方法及磷霉素 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1161974B (it) * | 1978-02-02 | 1987-03-18 | Italchemi Spa | Derivti dell acido cis.i 2 epossipropilfosfonico loro procedimento di preparazione e composizioni farmaceutiche che li contengono |
| DE3906953A1 (de) * | 1989-03-04 | 1990-09-20 | Byk Gulden Lomberg Chem Fab | Verfahren zur herstellung optisch reiner oxirancarbonsaeuren |
-
1968
- 1968-10-18 NL NL6814979A patent/NL6814979A/xx unknown
- 1968-10-21 IL IL30920A patent/IL30920A/xx unknown
- 1968-10-21 IE IE1252/68A patent/IE32997B1/xx unknown
- 1968-10-22 CH CH1578668A patent/CH527224A/de not_active IP Right Cessation
- 1968-10-23 OA OA53389A patent/OA03882A/fr unknown
- 1968-10-23 IT IT40661/68A patent/IT986758B/it active
- 1968-10-24 GB GB50638/68A patent/GB1239989A/en not_active Expired
- 1968-10-25 ES ES359542A patent/ES359542A1/es not_active Expired
- 1968-10-28 DE DE1805681A patent/DE1805681C3/de not_active Expired
- 1968-10-29 DK DK522068AA patent/DK139141B/da not_active IP Right Cessation
- 1968-10-29 SE SE6814621A patent/SE377941B/xx unknown
- 1968-10-29 FI FI683069A patent/FI51703C/fi active
- 1968-10-29 LU LU57184D patent/LU57184A1/xx unknown
- 1968-10-29 BE BE723073D patent/BE723073A/xx not_active IP Right Cessation
- 1968-10-29 NO NO4277/68A patent/NO132992C/no unknown
- 1968-10-30 FR FR1592150D patent/FR1592150A/fr not_active Expired
- 1968-10-30 RO RO58059A patent/RO54819A/ro unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109369718A (zh) * | 2018-12-07 | 2019-02-22 | 武汉工程大学 | 一种左磷右铵盐的制备方法及磷霉素 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1805681B2 (de) | 1974-02-14 |
| RO54819A (fr) | 1973-02-17 |
| FI51703B (fr) | 1976-11-30 |
| FR1592150A (fr) | 1970-05-11 |
| IE32997B1 (en) | 1974-02-20 |
| NL6814979A (fr) | 1969-05-02 |
| CH527224A (de) | 1972-08-31 |
| NO132992B (fr) | 1975-11-10 |
| DE1805681A1 (de) | 1969-12-11 |
| BE723073A (fr) | 1969-04-29 |
| SE377941B (fr) | 1975-08-04 |
| IE32997L (en) | 1969-04-30 |
| FI51703C (fi) | 1977-03-10 |
| IL30920A (en) | 1973-03-30 |
| DK139141C (fr) | 1979-05-28 |
| LU57184A1 (fr) | 1969-05-16 |
| NO132992C (fr) | 1976-02-18 |
| OA03882A (fr) | 1975-08-14 |
| IL30920A0 (en) | 1968-12-26 |
| IT986758B (it) | 1975-01-30 |
| DK139141B (da) | 1978-12-27 |
| ES359542A1 (es) | 1970-10-16 |
| DE1805681C3 (de) | 1974-09-19 |
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