ES471639A1 - Un metodo de separacion de la 3-(3,4-dibenciloxifenil)serinadiastereoisomerica - Google Patents

Un metodo de separacion de la 3-(3,4-dibenciloxifenil)serinadiastereoisomerica

Info

Publication number
ES471639A1
ES471639A1 ES471639A ES471639A ES471639A1 ES 471639 A1 ES471639 A1 ES 471639A1 ES 471639 A ES471639 A ES 471639A ES 471639 A ES471639 A ES 471639A ES 471639 A1 ES471639 A1 ES 471639A1
Authority
ES
Spain
Prior art keywords
mineral acid
serine
dibenzyloxyphenyl
isomer
diastereoisomeric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES471639A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of ES471639A1 publication Critical patent/ES471639A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un método de separación de la 3-(3,4-dibenciloxifenil) serina diastereoisomérica, que consiste en hacer reaccionar una mezcla de los isómeros treo y eritro de la 3-(3,4-dibenciloxifenil) serina con un ácido mineral y separar una mezcla de las sales de ácido mineral resultantes del isómero treo y del isómero eritro en cada una de las sales de ácido mineral utilizando la diferencia de solubilidades de dichas sales y opcionalmente convertir la sal de ácido mineral separada en el isómero libre.
ES471639A 1977-07-11 1978-07-11 Un metodo de separacion de la 3-(3,4-dibenciloxifenil)serinadiastereoisomerica Expired ES471639A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8312877A JPS5419931A (en) 1977-07-11 1977-07-11 Separation of threo, erythro-3-(3,4-dibenzyloxyphenyl)serines

Publications (1)

Publication Number Publication Date
ES471639A1 true ES471639A1 (es) 1979-02-01

Family

ID=13793551

Family Applications (1)

Application Number Title Priority Date Filing Date
ES471639A Expired ES471639A1 (es) 1977-07-11 1978-07-11 Un metodo de separacion de la 3-(3,4-dibenciloxifenil)serinadiastereoisomerica

Country Status (13)

Country Link
US (1) US4246428A (es)
JP (1) JPS5419931A (es)
AT (1) AT356646B (es)
AU (1) AU516261B2 (es)
BE (1) BE868797A (es)
CA (1) CA1100149A (es)
CH (1) CH634824A5 (es)
DE (1) DE2830475A1 (es)
ES (1) ES471639A1 (es)
FR (1) FR2397392A1 (es)
GB (1) GB2000779B (es)
IT (1) IT1159895B (es)
NL (1) NL7807469A (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4480109A (en) * 1982-01-14 1984-10-30 Sumitomo Chemical Company, Limited Process for producing threo-3-(3,4-dihydroxyphenyl)serine
JPS59112949A (ja) * 1982-12-20 1984-06-29 Microbial Chem Res Found 新規なｌ−スレオ−アドレナリン酸
CA1223602A (en) * 1983-05-25 1987-06-30 Naohito Ohashi Process for producing 3-(3,4-dihydroxyphenyl) serine
US8158149B2 (en) * 2004-05-12 2012-04-17 Chelsea Therapeutics, Inc. Threo-DOPS controlled release formulation
WO2004100929A1 (en) 2003-05-12 2004-11-25 Synergia Pharma, Inc. Threo-dops controlled release formulation
US20070010584A1 (en) * 2003-09-04 2007-01-11 Peroutka Stephen J Compositions and methods for orthostatic intolerance
EP2363123A1 (en) * 2006-06-28 2011-09-07 Chelsea Therapeutics, Inc. Pharmaceutical compositions comprising droxidopa
WO2008112562A1 (en) * 2007-03-09 2008-09-18 Chelsea Therapeutics, Inc. Droxidopa and pharmaceutical composition thereof for the treatment of fibromyalgia
WO2008137923A2 (en) * 2007-05-07 2008-11-13 Chelsea Therapeutics, Inc. Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders
JP5880913B2 (ja) 2011-05-17 2016-03-09 三郎 佐古田 パーキンソン病の体幹症状（姿勢反射異常）の治療剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182079A (en) * 1962-11-19 1965-05-04 Ajinomoto Kk Optical resolution of dl-valine
CH505785A (de) * 1969-02-07 1971-04-15 Hoffmann La Roche Verfahren zur Herstellung von (-)threo-3-(4-Hydroxy-3-methoxy-phenyl)-serin
US3830836A (en) * 1970-10-15 1974-08-20 Ajimoto Kk 3,4-dihydroxyphenylalanine hemihydrochloride

Also Published As

Publication number Publication date
JPS6131097B2 (es) 1986-07-17
CH634824A5 (de) 1983-02-28
GB2000779A (en) 1979-01-17
DE2830475A1 (de) 1979-01-25
NL7807469A (nl) 1979-01-15
US4246428A (en) 1981-01-20
IT1159895B (it) 1987-03-04
CA1100149A (en) 1981-04-28
JPS5419931A (en) 1979-02-15
IT7868640A0 (it) 1978-07-11
FR2397392A1 (fr) 1979-02-09
AU516261B2 (en) 1981-05-28
BE868797A (fr) 1979-01-08
ATA499578A (de) 1979-10-15
FR2397392B1 (es) 1982-04-30
AU3787078A (en) 1980-01-10
GB2000779B (en) 1982-01-20
AT356646B (de) 1980-05-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991108