GB1235688A - Improved process for preparing cephaloridine - Google Patents
Improved process for preparing cephaloridineInfo
- Publication number
- GB1235688A GB1235688A GB02531/68A GB1253168A GB1235688A GB 1235688 A GB1235688 A GB 1235688A GB 02531/68 A GB02531/68 A GB 02531/68A GB 1253168 A GB1253168 A GB 1253168A GB 1235688 A GB1235688 A GB 1235688A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cephaloridine
- solution
- acetone
- volume
- march
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CZTQZXZIADLWOZ-CRAIPNDOSA-N cefaloridine Chemical compound O=C([C@@H](NC(=O)CC=1SC=CC=1)[C@H]1SC2)N1C(C(=O)[O-])=C2C[N+]1=CC=CC=C1 CZTQZXZIADLWOZ-CRAIPNDOSA-N 0.000 title abstract 9
- 229960003866 cefaloridine Drugs 0.000 title abstract 9
- 238000004519 manufacturing process Methods 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 10
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- -1 inner salts Chemical class 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US625576A US3352859A (en) | 1967-03-24 | 1967-03-24 | Process for improving crystal quality of a cephalosporin antibiotic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1235688A true GB1235688A (en) | 1971-06-16 |
Family
ID=24506718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB02531/68A Expired GB1235688A (en) | 1967-03-24 | 1968-03-14 | Improved process for preparing cephaloridine |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3352859A (en:Method) |
| BE (1) | BE712149A (en:Method) |
| DE (1) | DE1670656C3 (en:Method) |
| FR (1) | FR1568979A (en:Method) |
| GB (1) | GB1235688A (en:Method) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1316964A (en) * | 1969-07-24 | 1973-05-16 | Glaxo Lab Ltd | Antibiotics |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL129633C (en:Method) * | 1965-03-05 |
-
1967
- 1967-03-24 US US625576A patent/US3352859A/en not_active Expired - Lifetime
-
1968
- 1968-03-14 BE BE712149D patent/BE712149A/xx unknown
- 1968-03-14 FR FR1568979D patent/FR1568979A/fr not_active Expired
- 1968-03-14 GB GB02531/68A patent/GB1235688A/en not_active Expired
- 1968-03-15 DE DE1670656A patent/DE1670656C3/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1670656B2 (de) | 1975-01-30 |
| DE1670656C3 (de) | 1975-09-18 |
| DE1670656A1 (de) | 1970-08-06 |
| FR1568979A (en:Method) | 1969-05-30 |
| US3352859A (en) | 1967-11-14 |
| BE712149A (en:Method) | 1968-09-16 |
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