GB1277228A - An improved process for the production of 7-aminocephalosporanic acid - Google Patents

An improved process for the production of 7-aminocephalosporanic acid

Info

Publication number
GB1277228A
GB1277228A GB4906769A GB4906769A GB1277228A GB 1277228 A GB1277228 A GB 1277228A GB 4906769 A GB4906769 A GB 4906769A GB 4906769 A GB4906769 A GB 4906769A GB 1277228 A GB1277228 A GB 1277228A
Authority
GB
United Kingdom
Prior art keywords
aminocephalosporanic acid
production
improved process
aca
oct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4906769A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB1277228A publication Critical patent/GB1277228A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1277228 Preparing 7-aminocephalosporanic acid ELI LILLY & CO 6 Oct 1969 [7 Oct 1968 26 Dec 1968] 49067/69 Heading C2A In a process for preparing 7-aminocephalosporanic acid (7-ACA) by treating cephalosporin C or its salt with a nitrosating agent, a carbocyclic arenediazonium salt or a compound that affords positive halogen, at not more than 60‹ C., quenching the reaction in a C 1 to C 3 alkanol and precipitating 7-ACA from the solution, the reaction mixture is treated before or during quenching with 2,2-dimethoxypropane or methyl formate. Reference has been directed by the Comptroller to Specifications 1,017,534 and 948,858.
GB4906769A 1968-10-07 1969-10-06 An improved process for the production of 7-aminocephalosporanic acid Expired GB1277228A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76564068A 1968-10-07 1968-10-07
US78724768A 1968-12-26 1968-12-26

Publications (1)

Publication Number Publication Date
GB1277228A true GB1277228A (en) 1972-06-07

Family

ID=27117629

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4906769A Expired GB1277228A (en) 1968-10-07 1969-10-06 An improved process for the production of 7-aminocephalosporanic acid

Country Status (5)

Country Link
JP (1) JPS4927197B1 (en)
CH (1) CH519518A (en)
DE (1) DE1950391A1 (en)
FR (1) FR2020062A1 (en)
GB (1) GB1277228A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055484A1 (en) * 1997-06-04 1998-12-10 Biochemie Gesellschaft Mbh Improved precipitation process of 7-aminocephalosporanic acid (7-aca)
US6518420B2 (en) 1997-06-04 2003-02-11 Biochemie Gesellschaft M.B.H. Precipitation process of 7-aminocephalosporanic acid (7-ACA)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5248297U (en) * 1975-10-01 1977-04-06

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055484A1 (en) * 1997-06-04 1998-12-10 Biochemie Gesellschaft Mbh Improved precipitation process of 7-aminocephalosporanic acid (7-aca)
US6518420B2 (en) 1997-06-04 2003-02-11 Biochemie Gesellschaft M.B.H. Precipitation process of 7-aminocephalosporanic acid (7-ACA)
KR100748387B1 (en) * 1997-06-04 2007-08-10 산도즈 게엠베하 Improved precipitation process of 7-aminocephalosporanic acid7-ACA

Also Published As

Publication number Publication date
DE1950391A1 (en) 1970-10-08
CH519518A (en) 1972-02-29
FR2020062A1 (en) 1970-07-10
JPS4927197B1 (en) 1974-07-16

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees