GB1235684A - Improvements in or relating to nitrogen-containing heterocyclic derivatives - Google Patents

Improvements in or relating to nitrogen-containing heterocyclic derivatives

Info

Publication number
GB1235684A
GB1235684A GB52985/67A GB5298567A GB1235684A GB 1235684 A GB1235684 A GB 1235684A GB 52985/67 A GB52985/67 A GB 52985/67A GB 5298567 A GB5298567 A GB 5298567A GB 1235684 A GB1235684 A GB 1235684A
Authority
GB
United Kingdom
Prior art keywords
alkoxy
substituted
optionally
phenylalkylthio
phenylalkylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB52985/67A
Inventor
Andrea Pedrazzoli
Leone Dall Asta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre de Recherches Marcel Midy
Original Assignee
Centre de Recherches Marcel Midy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre de Recherches Marcel Midy filed Critical Centre de Recherches Marcel Midy
Priority to GB52985/67A priority Critical patent/GB1235684A/en
Priority to FR1594756D priority patent/FR1594756A/fr
Priority to DE19681809286 priority patent/DE1809286B2/en
Priority to LU57339D priority patent/LU57339A1/xx
Priority to BE724007D priority patent/BE724007A/xx
Priority to SE1577368A priority patent/SE366546B/xx
Priority to CH1729668A priority patent/CH523881A/en
Priority to ES360460A priority patent/ES360460A1/en
Priority to BR20414368A priority patent/BR6804143D0/en
Priority to IN118661A priority patent/IN118661B/en
Priority to NL6816639A priority patent/NL6816639A/xx
Priority to SU1284072A priority patent/SU363246A3/ru
Priority to CS794668A priority patent/CS153023B2/cs
Priority to AT1132668A priority patent/AT283340B/en
Priority to IE141268A priority patent/IE32778B1/en
Priority to FR183247A priority patent/FR8276M/fr
Publication of GB1235684A publication Critical patent/GB1235684A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1,235,684. Basic alcohols, ethers and esters. CENTRE DE RECHERCHES MARCEL MIDY. 15 Nov., 1968 [21 Nov., 1967], No. 52985/67. Heading C2C. Compounds of the general formula (Z=CH 2 CH 2 , CH=CH, CH 2 CH 2 CH 2 , CH 2 CH= CH; R=H, saturated or unsaturated C 1-8 aliphatic group, R 2 CO; R 2 =saturated or unsaturated C 1-6 aliphatic group, or Ph, phenylalkyl, PhOCH 2 , PhSCH 2 optionally ring- substituted by 1-3 substituents selected from Me, alkoxy, halogen; R 1 =Ph, PhO, phenylalkoxy, PhS, phenylalkylthio, PhNH, phenylalkylamino optionally ring - substituted by 1 or 2 substituents selected from NO 2 , NH 2 , halogen, alkyl, alkoxy and C 5-6 cycloalkyl, 2 - naphthyl, 1,2,3,4 - tetrahydro - 6 - naphthyl, C 5-6 cycloalkyl, alkoxy, alkylthio; n=0-2; provided that R 1 =PhO, phenylalkoxy, PhS, phenylalkylthio, PhNH, phenylalkylamino, optionally substituted, only when Z=CH 2 CH 2 or CH=CH) and their acid addition salts are prepared by the following reactions: optionally followed by etherification or esterification and/or salt formation. The preparation of the heterocyclic starting materials by standard methods is described. The above compounds have sympathicolytic, myolytic, psychotropically tranquillizing and analgesic and local anaesthetic activity and may be administered in the form of pharmaceutical preparations contaning them in association with a carrier.
GB52985/67A 1967-11-21 1967-11-21 Improvements in or relating to nitrogen-containing heterocyclic derivatives Expired GB1235684A (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GB52985/67A GB1235684A (en) 1967-11-21 1967-11-21 Improvements in or relating to nitrogen-containing heterocyclic derivatives
FR1594756D FR1594756A (en) 1967-11-21 1968-11-08
DE19681809286 DE1809286B2 (en) 1967-11-21 1968-11-16 Tetramethyl-PyiTolidine
LU57339D LU57339A1 (en) 1967-11-21 1968-11-18
BE724007D BE724007A (en) 1967-11-21 1968-11-18
SE1577368A SE366546B (en) 1967-11-21 1968-11-20
CH1729668A CH523881A (en) 1967-11-21 1968-11-20 Process for the preparation of new heterocyclic derivatives
ES360460A ES360460A1 (en) 1967-11-21 1968-11-20 Improvements in or relating to nitrogen-containing heterocyclic derivatives
BR20414368A BR6804143D0 (en) 1967-11-21 1968-11-20 PROCESS FOR THE PREPARATION OF NEW HETEROCYCLICAL COMPOUNDS
IN118661A IN118661B (en) 1967-11-21 1968-11-20
NL6816639A NL6816639A (en) 1967-11-21 1968-11-21
SU1284072A SU363246A3 (en) 1967-11-21 1968-11-21
CS794668A CS153023B2 (en) 1967-11-21 1968-11-21
AT1132668A AT283340B (en) 1967-11-21 1968-11-21 Process for the preparation of new heterocyclic compounds and their salts
IE141268A IE32778B1 (en) 1967-11-21 1968-11-21 Improvements in or relating to nitrogen-containing heterocyclic derivatives
FR183247A FR8276M (en) 1967-11-21 1969-02-10

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB52985/67A GB1235684A (en) 1967-11-21 1967-11-21 Improvements in or relating to nitrogen-containing heterocyclic derivatives

Publications (1)

Publication Number Publication Date
GB1235684A true GB1235684A (en) 1971-06-16

Family

ID=10466156

Family Applications (1)

Application Number Title Priority Date Filing Date
GB52985/67A Expired GB1235684A (en) 1967-11-21 1967-11-21 Improvements in or relating to nitrogen-containing heterocyclic derivatives

Country Status (15)

Country Link
AT (1) AT283340B (en)
BE (1) BE724007A (en)
BR (1) BR6804143D0 (en)
CH (1) CH523881A (en)
CS (1) CS153023B2 (en)
DE (1) DE1809286B2 (en)
ES (1) ES360460A1 (en)
FR (2) FR1594756A (en)
GB (1) GB1235684A (en)
IE (1) IE32778B1 (en)
IN (1) IN118661B (en)
LU (1) LU57339A1 (en)
NL (1) NL6816639A (en)
SE (1) SE366546B (en)
SU (1) SU363246A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5823399B2 (en) * 1973-08-23 1983-05-14 ウェルファイド株式会社 Phenoxy Amino Probanol
JPS57136567A (en) * 1981-02-17 1982-08-23 Adeka Argus Chem Co Ltd N-2-hydroxy-3-substituted piperidine compound

Also Published As

Publication number Publication date
FR1594756A (en) 1970-06-08
IE32778B1 (en) 1973-11-28
ES360460A1 (en) 1970-07-01
DE1809286A1 (en) 1969-08-14
BR6804143D0 (en) 1973-01-09
DE1809286C3 (en) 1975-04-03
DE1809286B2 (en) 1974-08-01
AT283340B (en) 1970-08-10
SE366546B (en) 1974-04-29
LU57339A1 (en) 1969-02-26
IN118661B (en) 1975-08-16
CS153023B2 (en) 1974-02-22
FR8276M (en) 1970-11-02
BE724007A (en) 1969-05-02
SU363246A3 (en) 1972-12-30
IE32778L (en) 1969-05-21
NL6816639A (en) 1969-05-23
CH523881A (en) 1972-06-15

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