GB1227691A - - Google Patents

Info

Publication number
GB1227691A
GB1227691A GB1227691DA GB1227691A GB 1227691 A GB1227691 A GB 1227691A GB 1227691D A GB1227691D A GB 1227691DA GB 1227691 A GB1227691 A GB 1227691A
Authority
GB
United Kingdom
Prior art keywords
glycosyl
general formula
alkyl group
group
peracylglycosyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1227691A publication Critical patent/GB1227691A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
GB1227691D 1968-05-08 1969-04-24 Expired GB1227691A (US08058424-20111115-C00008.png)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS339968 1968-05-08

Publications (1)

Publication Number Publication Date
GB1227691A true GB1227691A (US08058424-20111115-C00008.png) 1971-04-07

Family

ID=5373920

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1227691D Expired GB1227691A (US08058424-20111115-C00008.png) 1968-05-08 1969-04-24

Country Status (12)

Country Link
JP (1) JPS4916435B1 (US08058424-20111115-C00008.png)
AT (1) AT306930B (US08058424-20111115-C00008.png)
BE (1) BE732268A (US08058424-20111115-C00008.png)
BR (1) BR6908600D0 (US08058424-20111115-C00008.png)
CA (1) CA921904A (US08058424-20111115-C00008.png)
CH (1) CH527207A (US08058424-20111115-C00008.png)
DE (1) DE1922702A1 (US08058424-20111115-C00008.png)
ES (1) ES366910A1 (US08058424-20111115-C00008.png)
FR (1) FR2008048A1 (US08058424-20111115-C00008.png)
GB (1) GB1227691A (US08058424-20111115-C00008.png)
IT (1) IT1037009B (US08058424-20111115-C00008.png)
NL (1) NL6906909A (US08058424-20111115-C00008.png)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004082822A2 (en) 2003-03-17 2004-09-30 Pharmion Corporation Methods for isolating crystalline form i of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US7038038B2 (en) 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
EP1765076A1 (en) * 2004-07-13 2007-03-28 SuperGen, Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8846628B2 (en) 2008-05-15 2014-09-30 Celgene Corporation Oral formulations of cytidine analogs and methods of use thereof
US9951098B2 (en) 2011-03-31 2018-04-24 Pharmion Llc Synthesis of 5-azacytidine

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2012888C3 (de) * 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden
US6905669B2 (en) 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
US6982253B2 (en) 2002-06-05 2006-01-03 Supergen, Inc. Liquid formulation of decitabine and use of the same
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
AU2009279461B2 (en) 2008-08-08 2014-01-23 Scinopharm Taiwan, Ltd. Process for making 5-azacytosine nucleosides and their derivatives
UA116528C2 (uk) 2011-08-30 2018-04-10 Астекс Фармасьютікалз, Інк. Склад, набір, фармацевтична композиція, що містять похідні децитабіну, їх отримання і застосування
WO2017004538A1 (en) 2015-07-02 2017-01-05 Otsuka Pharmaceutical Co., Ltd. Lyophilized pharmaceutical compositions
WO2017090264A1 (ja) 2015-11-27 2017-06-01 大原薬品工業株式会社 ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル
US10227374B2 (en) 2016-04-21 2019-03-12 Ohara Pharmaceutical Co., Ltd. Silyl etherified derivatives of 5-azacytidines in carbohydrate moiety
WO2017183215A1 (ja) 2016-04-21 2017-10-26 大原薬品工業株式会社 ５－アザシチジン類の糖部シリルエーテル誘導体
JP6162349B1 (ja) 2016-04-21 2017-07-12 大原薬品工業株式会社 ５−アザシチジン類の糖部シリルエーテル誘導体
WO2019025863A2 (en) 2017-08-03 2019-02-07 Otsuka Pharmaceutical Co., Ltd. MEDICAMENT COMPOUND AND METHODS OF PURIFICATION

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211862B2 (en) 2003-03-17 2012-07-03 Pharmion Llc Pharmaceutical compositions comprising crystal forms of 5-azacytidine
US6943249B2 (en) 2003-03-17 2005-09-13 Ash Stevens, Inc. Methods for isolating crystalline Form I of 5-azacytidine
EP2258710A1 (en) * 2003-03-17 2010-12-08 Celgene International Sarl New polymorphic form of 5-azacytidine
EP1608634A2 (en) * 2003-03-17 2005-12-28 Pharmion Corporation Methods for isolating crystalline form i of 5-azacytidine
EP1610784A2 (en) * 2003-03-17 2006-01-04 Pharmion Corporation Forms of 5-azacytidine
US7038038B2 (en) 2003-03-17 2006-05-02 Pharmion Corporation Synthesis of 5-azacytidine
US7078518B2 (en) 2003-03-17 2006-07-18 Pharmion Corporation Forms of 5-Azacytidine
US7772199B2 (en) 2003-03-17 2010-08-10 Celgene Corporation Forms of 5-azacytidine
EP1610784A4 (en) * 2003-03-17 2007-11-07 Pharmion Corp FORMS OF 5-AZACYTIDINE
WO2004082822A2 (en) 2003-03-17 2004-09-30 Pharmion Corporation Methods for isolating crystalline form i of 5-azacytidine
EP2258711B1 (en) 2003-03-17 2017-01-18 Celgene International Sarl New forms of 5-azacytidine
US8975392B2 (en) 2003-03-17 2015-03-10 Pharmion Llc Methods for isolating crystalline form I of 5-azacytidine
US7700770B2 (en) 2003-03-17 2010-04-20 Celgene Corporation Methods for isolating crystalline form I of 5-azacytidine
EP2181988A1 (en) 2003-03-17 2010-05-05 Pharmion Corporation Pharmaceutical Compositions based on Crystalline Form I of 5-Azacytidine
US9192620B2 (en) 2003-03-17 2015-11-24 Pharmion Llc Pharmaceutical compositions comprising forms of 5-azacytidine
US6887855B2 (en) 2003-03-17 2005-05-03 Pharmion Corporation Forms of 5-azacytidine
US7858774B2 (en) 2003-03-17 2010-12-28 Pharmion Llc Synthesis of 5-azacytidine
EP2270022A1 (en) * 2003-03-17 2011-01-05 Celgene International Sarl New polymorphic form of 5-azacytidine
EP2270023A1 (en) * 2003-03-17 2011-01-05 Celgene International Sarl New polymorphic form of 5-azacytidine
EP2258711A3 (en) * 2003-03-17 2011-03-30 Celgene International Sarl New forms of 5-azacytidine
US8058424B2 (en) 2003-03-17 2011-11-15 Pharmion Llc Synthesis of 5-azacytidine
EP2181988B1 (en) * 2003-03-17 2016-05-11 Celgene International Sarl Pharmaceutical Compositions based on Crystalline Form I of 5-Azacytidine
EP1608634B1 (en) * 2003-03-17 2013-05-22 Celgene International Sarl Methods for isolating crystalline form i of 5-azacytidine
US8481715B2 (en) 2003-03-17 2013-07-09 Pharmion Llc Methods for isolating crystalline form I of 5-azacytidine
US8513406B2 (en) 2003-03-17 2013-08-20 Pharmion Llc Pharmaceutical compositions comprising forms of 5-azacytidine
US8614313B2 (en) 2003-03-17 2013-12-24 Pharmion Llc Pharmaceutical compositions comprising forms of 5-azacytidine
US8779117B2 (en) 2003-03-17 2014-07-15 Pharmion Llc Pharmaceutical compositions comprising 5-azacytidine monohydrate
EP1610784B1 (en) 2003-03-17 2016-07-06 Celgene International Sarl Forms of 5-azacytidine
EP1765076A4 (en) * 2004-07-13 2009-04-22 Supergen Inc COMPOSITIONS AND FORMULATIONS OF DECITABIN POLYMORPHS AND METHODS OF USE THEREOF
EP1765076A1 (en) * 2004-07-13 2007-03-28 SuperGen, Inc. Compositions and formulations of decitabine polymorphs and methods of use thereof
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US8846628B2 (en) 2008-05-15 2014-09-30 Celgene Corporation Oral formulations of cytidine analogs and methods of use thereof
US10220050B2 (en) 2008-05-15 2019-03-05 Celgene Corporation Isotopologues of 5-azacytidine
US10463683B2 (en) 2008-05-15 2019-11-05 Celgene Corporation Isotopologues of 5-azacytidine
US10646503B2 (en) 2008-05-15 2020-05-12 Celgene Corporation Isotopologues of 5-azacytidine
US11571436B2 (en) 2008-05-15 2023-02-07 Celgene Corporation Oral formulations of cytidine analogs and methods of use thereof
US9951098B2 (en) 2011-03-31 2018-04-24 Pharmion Llc Synthesis of 5-azacytidine

Also Published As

Publication number Publication date
CH527207A (de) 1972-08-31
IT1037009B (it) 1979-11-10
NL6906909A (US08058424-20111115-C00008.png) 1969-11-11
JPS4916435B1 (US08058424-20111115-C00008.png) 1974-04-22
BE732268A (US08058424-20111115-C00008.png) 1969-10-01
BR6908600D0 (pt) 1973-02-22
FR2008048A1 (US08058424-20111115-C00008.png) 1970-01-16
CA921904A (en) 1973-02-27
DE1922702A1 (de) 1969-11-20
AT306930B (de) 1973-04-25
ES366910A1 (es) 1971-03-16

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees