GB1213571A - Derivatives of cephalosporanic acid - Google Patents
Derivatives of cephalosporanic acidInfo
- Publication number
- GB1213571A GB1213571A GB871/68A GB87168A GB1213571A GB 1213571 A GB1213571 A GB 1213571A GB 871/68 A GB871/68 A GB 871/68A GB 87168 A GB87168 A GB 87168A GB 1213571 A GB1213571 A GB 1213571A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- compounds
- pyridylthio
- cephalosporanic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YGBFLZPYDUKSPT-MRVPVSSYSA-N cephalosporanic acid Chemical class S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C[C@H]21 YGBFLZPYDUKSPT-MRVPVSSYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- -1 α-pyridylthioacetamido cephalosporanic acid derivative Chemical class 0.000 abstract 5
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 2
- BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 1
- HTLZVHNRZJPSMI-UHFFFAOYSA-N N-ethylpiperidine Chemical compound CCN1CCCCC1 HTLZVHNRZJPSMI-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 150000001767 cationic compounds Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 235000011167 hydrochloric acid Nutrition 0.000 abstract 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-O hydron;quinoline Chemical compound [NH+]1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-O 0.000 abstract 1
- 229910001411 inorganic cation Inorganic materials 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- 208000004396 mastitis Diseases 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 abstract 1
- 229960004919 procaine Drugs 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60737867A | 1967-01-05 | 1967-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1213571A true GB1213571A (en) | 1970-11-25 |
Family
ID=24432009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB871/68A Expired GB1213571A (en) | 1967-01-05 | 1968-01-05 | Derivatives of cephalosporanic acid |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT276626B (enrdf_load_stackoverflow) |
| BE (1) | BE709019A (enrdf_load_stackoverflow) |
| CH (1) | CH487181A (enrdf_load_stackoverflow) |
| DE (1) | DE1670301C3 (enrdf_load_stackoverflow) |
| DK (1) | DK126595B (enrdf_load_stackoverflow) |
| FR (2) | FR1580837A (enrdf_load_stackoverflow) |
| GB (1) | GB1213571A (enrdf_load_stackoverflow) |
| IL (1) | IL29235A (enrdf_load_stackoverflow) |
| NL (1) | NL6800176A (enrdf_load_stackoverflow) |
| NO (1) | NO140269C (enrdf_load_stackoverflow) |
| SE (1) | SE349564B (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2122603A (en) * | 1982-06-25 | 1984-01-18 | Lark Spa | 7-Ä???-(substituted-thio)-acylamidoÜ-cephalosporanic acids |
| EP0953570A1 (en) * | 1998-04-30 | 1999-11-03 | Eli Lilly And Company | Fluorinated cephalosporin antibiotics and their use for the treatment of mastitis |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE758764A (fr) * | 1969-11-13 | 1971-05-10 | Bristol Myers Co | Procede de preparation d'agents antibacteriens |
| US3631027A (en) * | 1970-03-27 | 1971-12-28 | Bristol Myers Co | Cephalosporanic acids |
| JPS5854157B2 (ja) * | 1977-06-10 | 1983-12-02 | 山之内製薬株式会社 | セフアロスポリン化合物の新規誘導体ならびにその製造方法 |
| DE2824559C2 (de) | 1977-06-10 | 1985-01-10 | Yamanouchi Pharmaceutical Co., Ltd., Tokio / Tokyo | 7α-Methoxy-7β-(4-substituierte-methylen-1,3-dithietan-2-yl)-carboxamido-3-Δ↑3↑-cephem-4-carbonsäuren, Verfahren zu deren Herstellung sowie ihre Verwendung |
| IT1141406B (it) * | 1980-04-01 | 1986-10-01 | Dob Far Spa | Sali della cefapirina con aminoacidi |
-
1967
- 1967-12-28 IL IL2923567A patent/IL29235A/xx unknown
-
1968
- 1968-01-03 DE DE19681670301 patent/DE1670301C3/de not_active Expired
- 1968-01-03 DK DK1368A patent/DK126595B/da not_active IP Right Cessation
- 1968-01-04 NO NO3568A patent/NO140269C/no unknown
- 1968-01-05 FR FR1580837D patent/FR1580837A/fr not_active Expired
- 1968-01-05 NL NL6800176A patent/NL6800176A/xx unknown
- 1968-01-05 SE SE14068A patent/SE349564B/xx unknown
- 1968-01-05 BE BE709019D patent/BE709019A/xx not_active IP Right Cessation
- 1968-01-05 AT AT13268A patent/AT276626B/de active
- 1968-01-05 CH CH15068A patent/CH487181A/de not_active IP Right Cessation
- 1968-01-05 GB GB871/68A patent/GB1213571A/en not_active Expired
- 1968-02-02 FR FR138533A patent/FR8381M/fr not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2122603A (en) * | 1982-06-25 | 1984-01-18 | Lark Spa | 7-Ä???-(substituted-thio)-acylamidoÜ-cephalosporanic acids |
| EP0953570A1 (en) * | 1998-04-30 | 1999-11-03 | Eli Lilly And Company | Fluorinated cephalosporin antibiotics and their use for the treatment of mastitis |
| US6369049B1 (en) | 1998-04-30 | 2002-04-09 | Eli Lilly And Company | Treatment of mastitis |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1670301B2 (de) | 1975-05-07 |
| CH487181A (de) | 1970-03-15 |
| SE349564B (enrdf_load_stackoverflow) | 1972-10-02 |
| IL29235A (en) | 1971-10-20 |
| FR8381M (enrdf_load_stackoverflow) | 1971-03-01 |
| NO140269C (no) | 1979-08-01 |
| DK126595B (da) | 1973-07-30 |
| BE709019A (enrdf_load_stackoverflow) | 1968-07-05 |
| DE1670301C3 (de) | 1975-12-18 |
| NO140269B (no) | 1979-04-23 |
| NL6800176A (enrdf_load_stackoverflow) | 1968-07-08 |
| AT276626B (de) | 1969-11-25 |
| FR1580837A (enrdf_load_stackoverflow) | 1969-09-12 |
| DE1670301A1 (de) | 1972-02-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES352625A1 (es) | Procedimiento para la preparacion de una cefalosporina 3,7-disustituida. | |
| GB1213571A (en) | Derivatives of cephalosporanic acid | |
| GB1298530A (en) | New imines, their preparation, and their pharmaceutical use | |
| GB1300718A (en) | 2-THIOMETHYL- AND 2-THIOMETHYLENE-Delta<3>-CEPHALOSPORIN COMPOUNDS AND SULFOXIDE THEREOF | |
| GB1289358A (enrdf_load_stackoverflow) | ||
| GB1322482A (en) | Glutamic acid derivatives their preparation and compositions containing the same | |
| GB1429539A (en) | Derivatives of penam-3-carboxylic acid and cephem-4-carboxylic acid and processes for their manufacture | |
| GB1432714A (en) | 7- alpha-halomethyl-arly- acetamide- cephalosporin derivatives | |
| GB1247711A (en) | Antibacterial agents and a process for the preparation thereof | |
| GB1318478A (en) | Cephalexin salts | |
| DE3419013A1 (de) | Neue cephalosporine und verfahren zu ihrer herstellung | |
| GB1162247A (en) | Cephalosporanic Acid Derivatives and a Process for the Preparation thereof | |
| GB1284227A (en) | Penicillin and cephalosporin derivatives | |
| GB1411700A (en) | Penicillins and production thereof | |
| GB1131645A (en) | Cephalosporins | |
| GB1137113A (en) | Cephalosporanic acid derivatives | |
| GB1057029A (en) | New penicillins | |
| GB1392241A (en) | Antibacterial agents and a process for the preparation thereof | |
| GB1166668A (en) | Penicillins and a process for the preparation thereof | |
| GB1252248A (enrdf_load_stackoverflow) | ||
| GB1134682A (en) | Improvements in or relating to derivatives of 6-aminopenicillanic acid | |
| GB1298088A (en) | Penicillanic acids | |
| GB1054209A (enrdf_load_stackoverflow) | ||
| GB1350238A (en) | Cephalosporin derivatives | |
| GB1334079A (en) | 7-alpha-2,6-dihalo-4-pyridylthio acetamido cephalosporanic acids and derivatives thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |