GB1202914A - 9,11-epoxy-13-alkylgona-1,3,5(10)-trien-8-ols, 11-oxygenated-13-alkylgona-1,3,5(10),8-tetraenes and related compounds - Google Patents
9,11-epoxy-13-alkylgona-1,3,5(10)-trien-8-ols, 11-oxygenated-13-alkylgona-1,3,5(10),8-tetraenes and related compoundsInfo
- Publication number
- GB1202914A GB1202914A GB4547267A GB4547267A GB1202914A GB 1202914 A GB1202914 A GB 1202914A GB 4547267 A GB4547267 A GB 4547267A GB 4547267 A GB4547267 A GB 4547267A GB 1202914 A GB1202914 A GB 1202914A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- alkylgona
- ols
- novel
- tetraenes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,202,914. Gona -1,3,5(10) - trienes and -1,3, 5(10),8 - tetraenes. AMERICAN HOME PRODUCTS CORP. 5 Oct., 1967 [10 Oct., 1966; 9 Nov., 1966; 8 May, 1967], No. 45472/67. Heading C2U. [Also in Division A5] Novel 9, 11 - epoxy - 13 - alkylgona - 1,3,5(10)- trien - 8 - ols are prepared by epoxidation of 13 - alkylgona - 1,3,5(10),8 - tetraenes or of 13 - alkylgona - 1,3,5(10),9(11) - tetraen - 8 - ols, and are converted under acidic conditions to 13 - alkylgona - 1,3,5(10),8 - tetraen - 11 - ones (most of which are novel), or, at elevated temperatures, to the corresponding novel 14# - epimers, also produced by epimerization of the 14α - compounds with acid or base. These tetraene products can be selectively reduced to the corresponding 1,3,5(10) - trienes (which are novel when they are 14# - compounds) before or after conversion to other 11-oxygenated compounds e.g. ketals or ols or their acylatos, if desired? In the tetraene or triene products a 17-OH group may be oxidized, esterified or etherified or a 17-oxo group may be reduced, ketalized, thioketalized or reacted with an organo-metallic reagent (to introduce an organic group at position -17 trans to the 13 - alkyl group with consequent formation of a 17-OH group cis to the 13 - alkyl group) or a 17 - ester group may be hydrolysed or a 17-ether group may be de-etherified, or a 17-ketalized or - thioketalized oxo group may be hydrolysed to a keto group. A11 these steriods may have the normal d- or the enantiomeric l-configuration or may be mixtures thereof e.g. racemates. Specification 1,196,643 is referred to.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58533966A | 1966-10-10 | 1966-10-10 | |
US59305966A | 1966-11-09 | 1966-11-09 | |
US63669367A | 1967-05-08 | 1967-05-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1202914A true GB1202914A (en) | 1970-08-19 |
Family
ID=27416453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4547267A Expired GB1202914A (en) | 1966-10-10 | 1967-10-05 | 9,11-epoxy-13-alkylgona-1,3,5(10)-trien-8-ols, 11-oxygenated-13-alkylgona-1,3,5(10),8-tetraenes and related compounds |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE1643595C3 (en) |
FR (2) | FR1561112A (en) |
GB (1) | GB1202914A (en) |
-
1967
- 1967-10-05 GB GB4547267A patent/GB1202914A/en not_active Expired
- 1967-10-10 FR FR1561112D patent/FR1561112A/fr not_active Expired
- 1967-10-10 DE DE19671643595 patent/DE1643595C3/en not_active Expired
-
1968
- 1968-01-09 FR FR135339A patent/FR7825M/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE1643595C3 (en) | 1974-02-21 |
DE1643595A1 (en) | 1972-06-08 |
FR7825M (en) | 1970-05-25 |
DE1643595B2 (en) | 1973-07-26 |
FR1561112A (en) | 1969-02-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PLNP | Patent lapsed through nonpayment of renewal fees |