GB1190077A - Peptides and Process for Preparing them - Google Patents

Peptides and Process for Preparing them

Info

Publication number
GB1190077A
GB1190077A GB26991/67A GB2699167A GB1190077A GB 1190077 A GB1190077 A GB 1190077A GB 26991/67 A GB26991/67 A GB 26991/67A GB 2699167 A GB2699167 A GB 2699167A GB 1190077 A GB1190077 A GB 1190077A
Authority
GB
United Kingdom
Prior art keywords
peptide
amino acid
dimethoxybenzyl
group
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB26991/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of GB1190077A publication Critical patent/GB1190077A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/066—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amido functions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1,190,077. Peptides. FARBWERKE HOECHST A.G. 12 June, 1967 [11 June, 1966], No. 26991/67. Heading C2C. Peptides, optionally blocked by one or more conventional amino and/or carboxylic acid protecting groups, are prepared by condensing a first amino acid or peptide which has an N-acyl substituent and also has a free or activated carboxyl group, with a second amino acid or peptide the second amino acid or peptide having an amino group which may be substituted by a 2,4-dimethoxybenzyl group, that is capable of reacting with the free or activated carboxyl group of the first amino acid or peptide and at least one -CONH- and/or -CONH 2 group of the first or second amino acid and/or peptide employed being completely or partially substituted by one or more 2,4-dimethoxybenzyl groups, and, if desired, subsequently splitting off one or more 2,4-dimethoxybenzyl groups and/or one or more conventional amino and/or carboxylic acid protecting groups. The 2,4- dimethoxybenzyl groups are split off by treatment with strong inorganic or organic acids or in the case of use as -CONH- substituent, by treatment with Na in liquid NH 3 .
GB26991/67A 1966-06-11 1967-06-12 Peptides and Process for Preparing them Expired GB1190077A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF0049448 1966-06-11

Publications (1)

Publication Number Publication Date
GB1190077A true GB1190077A (en) 1970-04-29

Family

ID=7103036

Family Applications (1)

Application Number Title Priority Date Filing Date
GB26991/67A Expired GB1190077A (en) 1966-06-11 1967-06-12 Peptides and Process for Preparing them

Country Status (2)

Country Link
GB (1) GB1190077A (en)
NL (1) NL6707845A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319378A1 (en) * 1975-07-28 1977-02-25 Ayerst Mckenna & Harrison TRIPEPTIDES AND THEIR PREPARATION

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931184A (en) * 1974-10-31 1976-01-06 Abbott Laboratories Purification method for prolyl-leucylglycinamide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319378A1 (en) * 1975-07-28 1977-02-25 Ayerst Mckenna & Harrison TRIPEPTIDES AND THEIR PREPARATION

Also Published As

Publication number Publication date
DE1543601A1 (en) 1969-07-31
NL6707845A (en) 1967-12-12

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees