ES281304A1 - A procedure for the preparation of new hypotensive polypeptides (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of new hypotensive polypeptides (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES281304A1 ES281304A1 ES281304A ES281304A ES281304A1 ES 281304 A1 ES281304 A1 ES 281304A1 ES 281304 A ES281304 A ES 281304A ES 281304 A ES281304 A ES 281304A ES 281304 A1 ES281304 A1 ES 281304A1
- Authority
- ES
- Spain
- Prior art keywords
- methioninamide
- phenylalanyl
- leucyl
- alanyl
- glycyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A process for the preparation of new hypotensive polypeptides, of the following general formula R-l-alanil-l-fenilalanil-l-isoleucil-glicil-l-leucil-l-metioninamida Whence r eliges en el grupo constituído por hidrºgeno l-aspartyl, l-glutaminyl-l-propyl-l-seryl-l-lysyl-l-asparatyl yl-pyroglutamyl-l-prolyl-l-seryl-l-lisyl-l -aspartilo, Characterized by the fact that a tripeptide derivative l-alanyl-l-phenylalanyl-l-isoleucine, having an amino group protecting group, is condensed with the tripeptide glycyl-l-leucyl-l-methioninamide and by the fact that that, after removal of the protecting group, the hexapeptide l-alanyl-l-phenylalanyl-l-isoleucyl-glycyl-l-leucyl-l-methioninamide is condensed with an aspatic acid derivative having an amino group protecting group and of beta-carboxyl group and by the fact that the resulting heptapeptide l-aspartyl-l-alanyl-l-phenylalanyl-l-isoleucyl-glycyl-l-leucyl-l-methioninamide, having a protected carboxyl group, is condensed with the tetrapeptide l-glutaminyl-l-seryl-l-lysine, which has the amino groups protected, and by the fact that, after removal of the protective groups, the resulting endecappetido l-glutaminil-l-prolyl-l -seril-l-aspartyl-l-alanyl-l-phenylalanyl-l-isoleucyl-glycyl-l-leucyl-l-methioninamide becomes the endecapeptide or l-pyroglutamyl-l-prolyl-l-seryl-l-lysyl-l-aspartyl-l-alanyl-l-phenylalanyl-l-isoleucyl-glycyl-l-leucyl-l-methioninamide by removal of ammonia. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1798361 | 1961-10-05 | ||
| IT216162 | 1962-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES281304A1 true ES281304A1 (en) | 1963-04-16 |
Family
ID=26325222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES281304A Expired ES281304A1 (en) | 1961-10-05 | 1962-10-04 | A procedure for the preparation of new hypotensive polypeptides (Machine-translation by Google Translate, not legally binding) |
Country Status (7)
| Country | Link |
|---|---|
| CH (1) | CH429754A (en) |
| DE (1) | DE1518133B1 (en) |
| DK (2) | DK104307C (en) |
| ES (1) | ES281304A1 (en) |
| FR (1) | FR2822M (en) |
| GB (1) | GB984810A (en) |
| SE (1) | SE302617B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1681495B (en) | 2002-08-19 | 2010-05-12 | 辉瑞产品公司 | Combination therapy for hyperplasia diseases |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US8383660B2 (en) | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| JP5498168B2 (en) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | N-((3-Benzyl) -2,2- (bis-phenyl) -propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular disease |
| EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| BR112021013807A2 (en) | 2019-01-18 | 2021-11-30 | Astrazeneca Ab | pcsk9 inhibitors and their methods of use |
-
1962
- 1962-10-01 GB GB37178/62A patent/GB984810A/en not_active Expired
- 1962-10-01 DE DE19621518133 patent/DE1518133B1/en active Pending
- 1962-10-02 CH CH1155562A patent/CH429754A/en unknown
- 1962-10-03 FR FR911147A patent/FR2822M/en not_active Expired
- 1962-10-03 DK DK428662AA patent/DK104307C/en active
- 1962-10-03 DK DK352664AA patent/DK108976C/en active
- 1962-10-04 ES ES281304A patent/ES281304A1/en not_active Expired
- 1962-10-04 SE SE10643/62A patent/SE302617B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB984810A (en) | 1965-03-03 |
| SE302617B (en) | 1968-07-29 |
| DK104307C (en) | 1966-05-02 |
| CH429754A (en) | 1967-02-15 |
| DE1518133B1 (en) | 1970-08-20 |
| DK108976C (en) | 1968-03-04 |
| FR2822M (en) | 1964-10-05 |
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