GB1181570A - Substituted Quinazolinones - Google Patents
Substituted QuinazolinonesInfo
- Publication number
- GB1181570A GB1181570A GB55090/67A GB5509067A GB1181570A GB 1181570 A GB1181570 A GB 1181570A GB 55090/67 A GB55090/67 A GB 55090/67A GB 5509067 A GB5509067 A GB 5509067A GB 1181570 A GB1181570 A GB 1181570A
- Authority
- GB
- United Kingdom
- Prior art keywords
- possibly substituted
- chlorobenzophenone
- amino
- methoxy
- dec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- XLJMAIOERFSOGZ-UHFFFAOYSA-N cyanic acid Chemical compound OC#N XLJMAIOERFSOGZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- ZVPLWDRTHNDLQO-UHFFFAOYSA-N (2-amino-5-chloro-3-methylphenyl)-phenylmethanone Chemical compound CC1=CC(Cl)=CC(C(=O)C=2C=CC=CC=2)=C1N ZVPLWDRTHNDLQO-UHFFFAOYSA-N 0.000 abstract 1
- LCKFJCYGXROYET-UHFFFAOYSA-N (2-amino-5-methylsulfonylphenyl)-phenylmethanone Chemical compound NC1=C(C(=O)C2=CC=CC=C2)C=C(C=C1)S(=O)(=O)C LCKFJCYGXROYET-UHFFFAOYSA-N 0.000 abstract 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- CKDWPUIZGOQOOM-UHFFFAOYSA-N Carbamyl chloride Chemical compound NC(Cl)=O CKDWPUIZGOQOOM-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 229940075930 picrate Drugs 0.000 abstract 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 abstract 1
- 201000003068 rheumatic fever Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR85985A FR6001M (enrdf_load_stackoverflow) | 1966-12-02 | 1966-12-02 | |
| FR97203A FR1520743A (fr) | 1966-12-02 | 1967-03-02 | Nouvelles quinazolinones substituées et procédé de préparation |
| FR106810A FR6158M (enrdf_load_stackoverflow) | 1966-12-02 | 1967-05-18 | |
| FR125422 | 1967-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1181570A true GB1181570A (en) | 1970-02-18 |
Family
ID=27444746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB55090/67A Expired GB1181570A (en) | 1966-12-02 | 1967-12-04 | Substituted Quinazolinones |
Country Status (7)
| Country | Link |
|---|---|
| CH (1) | CH482685A (enrdf_load_stackoverflow) |
| DE (1) | DE1695656B2 (enrdf_load_stackoverflow) |
| DK (1) | DK127332B (enrdf_load_stackoverflow) |
| FR (3) | FR6001M (enrdf_load_stackoverflow) |
| GB (1) | GB1181570A (enrdf_load_stackoverflow) |
| IL (1) | IL28991A (enrdf_load_stackoverflow) |
| NL (1) | NL6716429A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071516A (en) | 1976-08-20 | 1978-01-31 | Sandoz, Inc. | 4-(Acyloxyphenyl)-quinazolin-2(1H)-ones |
| WO2002102782A3 (en) * | 2001-06-15 | 2003-05-01 | Novartis Ag | QUINAZOLINE DERIVATIVES which PROMOTE THE RELEASE OF PARATHYROID_HORMONE |
| US8569317B2 (en) | 2002-12-23 | 2013-10-29 | Novartis Ag | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3923803A (en) * | 1968-07-18 | 1975-12-02 | Sumitomo Chemical Co | 2(1H)-Quinozalinones and process therefor |
| DE1932402C3 (de) * | 1969-06-26 | 1981-09-03 | Sandoz-Patent-GmbH, 7850 Lörrach | 1-Isopropyl-4-phenyl-3,4-dihydro-2(1H)chinazolinonderivate und deren Weiterverarbeitung zu 1-Isopropyl-4-phenyl-2(1H)chinazolinonen |
| DE2118315C3 (de) * | 1970-04-20 | 1975-04-03 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US3950526A (en) | 1970-04-20 | 1976-04-13 | Sumitomo Chemical Company, Limited | Quinazoline derivatives in pharmaceutical compositions for treating pain and inflammation |
| US3764600A (en) * | 1970-10-06 | 1973-10-09 | Sandoz Ag | 1-substituted-quinazoline-2(1h)-thiones |
| US3925549A (en) * | 1970-10-06 | 1975-12-09 | Sandoz Ag | 1-Substituted-quinazoline-2(1H)-thiones in the treatment of inflammation |
| US4202895A (en) | 1971-06-04 | 1980-05-13 | Sumitomo Chemical Company, Limited | 1-Polyhaloalkyl-2(1H)-quinazolinone derivatives |
| AU2013246278B2 (en) * | 2012-04-10 | 2016-11-03 | Annji Pharmaceutical Co., Ltd. | Histone deacetylases (HDAC) inhibitors |
-
1966
- 1966-12-02 FR FR85985A patent/FR6001M/fr not_active Expired
-
1967
- 1967-03-02 FR FR97203A patent/FR1520743A/fr not_active Expired
- 1967-05-18 FR FR106810A patent/FR6158M/fr not_active Expired
- 1967-11-21 IL IL2899167A patent/IL28991A/xx unknown
- 1967-11-23 CH CH1645167A patent/CH482685A/fr not_active IP Right Cessation
- 1967-12-01 NL NL6716429A patent/NL6716429A/xx unknown
- 1967-12-01 DK DK603267A patent/DK127332B/da not_active IP Right Cessation
- 1967-12-01 DE DE1967R0047487 patent/DE1695656B2/de active Granted
- 1967-12-04 GB GB55090/67A patent/GB1181570A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071516A (en) | 1976-08-20 | 1978-01-31 | Sandoz, Inc. | 4-(Acyloxyphenyl)-quinazolin-2(1H)-ones |
| WO2002102782A3 (en) * | 2001-06-15 | 2003-05-01 | Novartis Ag | QUINAZOLINE DERIVATIVES which PROMOTE THE RELEASE OF PARATHYROID_HORMONE |
| AU2002325242B2 (en) * | 2001-06-15 | 2006-11-09 | Novartis Ag | Quinazoline derivatives which promote the release of parathyroid hormone |
| EP2191832A1 (en) | 2001-06-15 | 2010-06-02 | Novartis AG | Quinazoline derivatives which promote the release of parathyroid hormone |
| US8476286B2 (en) | 2001-06-15 | 2013-07-02 | Novartis Ag | Quinazoline derivatives which promote the release of parathyroid hormone |
| US8569317B2 (en) | 2002-12-23 | 2013-10-29 | Novartis Ag | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1695656B2 (de) | 1974-06-06 |
| IL28991A (en) | 1972-11-28 |
| DK127332B (da) | 1973-10-22 |
| DE1695656A1 (de) | 1972-04-13 |
| FR1520743A (fr) | 1968-04-12 |
| NL6716429A (enrdf_load_stackoverflow) | 1968-06-04 |
| FR6001M (enrdf_load_stackoverflow) | 1968-04-29 |
| CH482685A (fr) | 1969-12-15 |
| DE1695656C3 (enrdf_load_stackoverflow) | 1979-12-06 |
| FR6158M (enrdf_load_stackoverflow) | 1968-07-01 |
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