GB1176821A - Sulphomethyl Derivatives of Polymyxin B. - Google Patents
Sulphomethyl Derivatives of Polymyxin B.Info
- Publication number
- GB1176821A GB1176821A GB780867A GB780867A GB1176821A GB 1176821 A GB1176821 A GB 1176821A GB 780867 A GB780867 A GB 780867A GB 780867 A GB780867 A GB 780867A GB 1176821 A GB1176821 A GB 1176821A
- Authority
- GB
- United Kingdom
- Prior art keywords
- sulphomethyl
- polymyxin
- reaction mixture
- filtered
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1,176,821. N-sulphomethyl polymyxin B. CHAS PFIZER & CO., Inc. 17 Feb., 1967 [2 June, 1966], No. 7808/67. Heading C2A. A pH and potency stabilized N-sulphomethyl polymyxin B is prepared by hydrolyzing an aqueous solution of N-sulphomethyl polymyxin B sodium salt at an elevated temperature, e.g. 50-60‹ C., while adding sufficient physiologically acceptable acid to the reaction mixture to maintain the pH thereof between 6À5 and 7À4 until the reaction mixture attains a constant pH between 7À0 and 7À2 and then recovering the resulting product. The preferred acid is sulphuric, but hydrochloric, succinic, citric, ascorbic, maleic and gluconic may be used. On completion, the reaction mixture may be filtered with filter aid, sterile filtered and lyophilized. A therapeutic composition for the treatment of coliform infections in animals comprises the above N-sulphomethyl polymyxin B in an injectable vehicle.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55466566A | 1966-06-02 | 1966-06-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1176821A true GB1176821A (en) | 1970-01-07 |
Family
ID=24214228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB780867A Expired GB1176821A (en) | 1966-06-02 | 1967-02-17 | Sulphomethyl Derivatives of Polymyxin B. |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB1176821A (en) |
-
1967
- 1967-02-17 GB GB780867A patent/GB1176821A/en not_active Expired
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