GB1173321A - Pharmaceutical Compositions containing Proscillaridin A - Google Patents
Pharmaceutical Compositions containing Proscillaridin AInfo
- Publication number
- GB1173321A GB1173321A GB5394166A GB5394166A GB1173321A GB 1173321 A GB1173321 A GB 1173321A GB 5394166 A GB5394166 A GB 5394166A GB 5394166 A GB5394166 A GB 5394166A GB 1173321 A GB1173321 A GB 1173321A
- Authority
- GB
- United Kingdom
- Prior art keywords
- theophylline
- proscillaridin
- carbon atoms
- hydroxy
- dec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MYEJFUXQJGHEQK-ALRJYLEOSA-N Proscillaridin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C=C2CC[C@H]3[C@@]4(O)CC[C@H](C5=COC(=O)C=C5)[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1 MYEJFUXQJGHEQK-ALRJYLEOSA-N 0.000 title abstract 3
- 229960003584 proscillaridin Drugs 0.000 title abstract 3
- MYEJFUXQJGHEQK-UHFFFAOYSA-N proscillaridin A Natural products OC1C(O)C(O)C(C)OC1OC1C=C2CCC3C4(O)CCC(C5=COC(=O)C=C5)C4(C)CCC3C2(C)CC1 MYEJFUXQJGHEQK-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000000150 Sympathomimetic Substances 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 230000001975 sympathomimetic effect Effects 0.000 abstract 3
- 229960000278 theophylline Drugs 0.000 abstract 3
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- -1 phenylepherine Chemical compound 0.000 abstract 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 abstract 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 abstract 1
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- KZZBAIXGUQOHKI-CEAXSRTFSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;4-[1-hydroxy-2-(methylamino)ethyl]phenol Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.CNCC(O)C1=CC=C(O)C=C1.CNCC(O)C1=CC=C(O)C=C1 KZZBAIXGUQOHKI-CEAXSRTFSA-N 0.000 abstract 1
- SQVIAVUSQAWMKL-UHFFFAOYSA-N 3-[2-(ethylamino)-1-hydroxyethyl]phenol Chemical compound CCNCC(O)C1=CC=CC(O)=C1 SQVIAVUSQAWMKL-UHFFFAOYSA-N 0.000 abstract 1
- UCTWMZQNUQWSLP-UHFFFAOYSA-N Adrenaline Natural products CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- WXFIGDLSSYIKKV-RCOVLWMOSA-N L-Metaraminol Chemical compound C[C@H](N)[C@H](O)C1=CC=CC(O)=C1 WXFIGDLSSYIKKV-RCOVLWMOSA-N 0.000 abstract 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M Methanesulfonate Chemical compound CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229940102884 adrenalin Drugs 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000000297 inotrophic effect Effects 0.000 abstract 1
- 229940039009 isoproterenol Drugs 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 abstract 1
- 229960003663 metaraminol Drugs 0.000 abstract 1
- 229960002657 orciprenaline Drugs 0.000 abstract 1
- OXFGTKPPFSCSMA-XVKPBYJWSA-N oxilofrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=C(O)C=C1 OXFGTKPPFSCSMA-XVKPBYJWSA-N 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- SBUQZKJEOOQSBV-UHFFFAOYSA-N pholedrine Chemical compound CNC(C)CC1=CC=C(O)C=C1 SBUQZKJEOOQSBV-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 229940064707 sympathomimetics Drugs 0.000 abstract 1
- YRCWQPVGYLYSOX-UHFFFAOYSA-N synephrine Chemical compound CNCC(O)C1=CC=C(O)C=C1 YRCWQPVGYLYSOX-UHFFFAOYSA-N 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical class CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEB0085102 | 1965-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1173321A true GB1173321A (en) | 1969-12-10 |
Family
ID=6982752
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5394166A Expired GB1173321A (en) | 1965-12-22 | 1966-12-01 | Pharmaceutical Compositions containing Proscillaridin A |
| GB2723569A Expired GB1173322A (en) | 1965-12-22 | 1966-12-01 | Pharmaceutical Compositions containing Proscillaridin A |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2723569A Expired GB1173322A (en) | 1965-12-22 | 1966-12-01 | Pharmaceutical Compositions containing Proscillaridin A |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE691525A (enrdf_load_stackoverflow) |
| CH (1) | CH504869A (enrdf_load_stackoverflow) |
| DE (1) | DE1467801A1 (enrdf_load_stackoverflow) |
| ES (1) | ES334627A1 (enrdf_load_stackoverflow) |
| FR (1) | FR7014M (enrdf_load_stackoverflow) |
| GB (2) | GB1173321A (enrdf_load_stackoverflow) |
| NL (2) | NL6617599A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4536236A2 (en) * | 2022-06-06 | 2025-04-16 | University of Utah Research Foundation | Methods of modulating atxn2 expression |
-
1965
- 1965-12-22 DE DE19651467801 patent/DE1467801A1/de active Pending
-
1966
- 1966-12-01 GB GB5394166A patent/GB1173321A/en not_active Expired
- 1966-12-01 GB GB2723569A patent/GB1173322A/en not_active Expired
- 1966-12-14 NL NL6617599A patent/NL6617599A/xx unknown
- 1966-12-17 ES ES334627A patent/ES334627A1/es not_active Expired
- 1966-12-20 BE BE691525D patent/BE691525A/xx unknown
- 1966-12-20 FR FR88166A patent/FR7014M/fr not_active Expired
- 1966-12-21 CH CH1824466A patent/CH504869A/de not_active IP Right Cessation
-
1971
- 1971-02-09 NL NL7101670A patent/NL7101670A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7101670A (enrdf_load_stackoverflow) | 1971-05-25 |
| ES334627A1 (es) | 1968-03-16 |
| CH504869A (de) | 1971-03-31 |
| FR7014M (enrdf_load_stackoverflow) | 1969-06-09 |
| BE691525A (enrdf_load_stackoverflow) | 1967-06-20 |
| NL6617599A (enrdf_load_stackoverflow) | 1967-06-23 |
| DE1467801A1 (de) | 1968-12-12 |
| GB1173322A (en) | 1969-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |