GB1158250A - Imidazoline Derivatives - Google Patents
Imidazoline DerivativesInfo
- Publication number
- GB1158250A GB1158250A GB22585/68A GB2258568A GB1158250A GB 1158250 A GB1158250 A GB 1158250A GB 22585/68 A GB22585/68 A GB 22585/68A GB 2258568 A GB2258568 A GB 2258568A GB 1158250 A GB1158250 A GB 1158250A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chloronaphthyl
- salt
- reacting
- ethylene diamine
- acetonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002462 imidazolines Chemical class 0.000 title abstract 2
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 8
- -1 4 - chloro - naphthyl Chemical group 0.000 abstract 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N methyl cyanide Natural products CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 5
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 4
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- AZFWKWBXGOGJOI-UHFFFAOYSA-N 1-chloro-4-(chloromethyl)naphthalene Chemical compound C1=CC=C2C(CCl)=CC=C(Cl)C2=C1 AZFWKWBXGOGJOI-UHFFFAOYSA-N 0.000 abstract 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229940035423 ethyl ether Drugs 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 230000003639 vasoconstrictive effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH741567A CH469007A (fr) | 1967-05-25 | 1967-05-25 | Procédé de préparation d'un nouveau dérivé de l'imidazoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1158250A true GB1158250A (en) | 1969-07-16 |
Family
ID=4324768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22585/68A Expired GB1158250A (en) | 1967-05-25 | 1968-05-13 | Imidazoline Derivatives |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3546242A (enExample) |
| AT (1) | AT277237B (enExample) |
| BE (1) | BE713057A (enExample) |
| CH (1) | CH469007A (enExample) |
| DK (1) | DK117901B (enExample) |
| ES (1) | ES352647A1 (enExample) |
| FR (2) | FR1566851A (enExample) |
| GB (1) | GB1158250A (enExample) |
| IL (1) | IL29800A (enExample) |
| NL (1) | NL6806813A (enExample) |
| NO (1) | NO123850B (enExample) |
| SE (1) | SE337826B (enExample) |
| YU (1) | YU117868A (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE239013T1 (de) * | 1997-12-19 | 2003-05-15 | Lilly Co Eli | Hypoglykamische imidazoline derivate |
| EP1266897A3 (en) * | 1997-12-19 | 2003-12-03 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| GB2351082A (en) * | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
| US20040009976A1 (en) * | 2002-04-30 | 2004-01-15 | Kumiko Takeuchi | Hypoglycemic imidazoline compounds |
| CN103224468A (zh) * | 2013-05-10 | 2013-07-31 | 范强 | 四氢唑林的合成方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2948724A (en) * | 1958-04-21 | 1960-08-09 | Sahyun | Halogenated derivatives of tetrahydro-1-naphthyl cyclic amidines |
-
1967
- 1967-05-25 CH CH741567A patent/CH469007A/fr unknown
-
1968
- 1968-04-01 BE BE713057D patent/BE713057A/xx unknown
- 1968-04-10 IL IL29800A patent/IL29800A/xx unknown
- 1968-04-10 ES ES352647A patent/ES352647A1/es not_active Expired
- 1968-04-19 AT AT384668A patent/AT277237B/de not_active IP Right Cessation
- 1968-04-22 FR FR1566851D patent/FR1566851A/fr not_active Expired
- 1968-05-09 DK DK220568AA patent/DK117901B/da unknown
- 1968-05-10 US US728342A patent/US3546242A/en not_active Expired - Lifetime
- 1968-05-13 GB GB22585/68A patent/GB1158250A/en not_active Expired
- 1968-05-14 NL NL6806813A patent/NL6806813A/xx unknown
- 1968-05-20 YU YU01178/68A patent/YU117868A/xx unknown
- 1968-05-22 SE SE06949/68A patent/SE337826B/xx unknown
- 1968-05-22 NO NO2004/68A patent/NO123850B/no unknown
- 1968-07-16 FR FR159357A patent/FR7670M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL29800A0 (en) | 1968-06-20 |
| YU117868A (en) | 1973-10-31 |
| NO123850B (enExample) | 1972-01-24 |
| FR1566851A (enExample) | 1969-05-09 |
| DE1770476A1 (enExample) | 1972-07-06 |
| IL29800A (en) | 1971-04-28 |
| CH469007A (fr) | 1969-02-28 |
| FR7670M (enExample) | 1970-02-09 |
| NL6806813A (enExample) | 1968-11-26 |
| SE337826B (enExample) | 1971-08-23 |
| AT277237B (de) | 1969-12-10 |
| BE713057A (enExample) | 1968-08-16 |
| DK117901B (da) | 1970-06-15 |
| US3546242A (en) | 1970-12-08 |
| ES352647A1 (es) | 1969-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |