GB1155310A - Process for Increasing the Yield of Tylosin Produced by Fermentation of Microorganisms. - Google Patents

Process for Increasing the Yield of Tylosin Produced by Fermentation of Microorganisms.

Info

Publication number
GB1155310A
GB1155310A GB48080/66A GB4808066A GB1155310A GB 1155310 A GB1155310 A GB 1155310A GB 48080/66 A GB48080/66 A GB 48080/66A GB 4808066 A GB4808066 A GB 4808066A GB 1155310 A GB1155310 A GB 1155310A
Authority
GB
United Kingdom
Prior art keywords
tylosin
fermentation
mcg
produced
hydrolyzate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB48080/66A
Inventor
Paul Gene Caltrider
Harold Bernard Hayes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to GB48080/66A priority Critical patent/GB1155310A/en
Publication of GB1155310A publication Critical patent/GB1155310A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

1,155,310. The antibiotic tylosin. ELI LILLY & CO. 26 Oct., 1966, No. 48080/66. Heading C2A. The antibiotic tylosin is produced in increased yield by the fermentation of Streptomyces fradiae NRRL 2702 or NRRL 2703 in a nutrient medium containing, as additive, 25 mcg./ml. to 1500 mcg./ml. of a crude tylosine hydrolyzate, desmycosin, O-mycaminosyl tylonolide, dihydrodesmycosin, dihydro - O - mycaminosyl tylonolide, mycarose, mycinose or mycaminose. The crude tylosin hydrolyzate may be produced by heating an aqueous solution of tylosin, or a salt thereof, at pH 2À0, washing the resulting mixture with an immiscible organic solvent, and concentrating the aqueous phase to dryness. It is preferred to add 100 to 200 mcg./ml. of the additive, and to make the addition up to 48 hours after the initiation of the fermentation. Tylosin is recovered from the fermentation broth in a conventional manner.
GB48080/66A 1966-10-26 1966-10-26 Process for Increasing the Yield of Tylosin Produced by Fermentation of Microorganisms. Expired GB1155310A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB48080/66A GB1155310A (en) 1966-10-26 1966-10-26 Process for Increasing the Yield of Tylosin Produced by Fermentation of Microorganisms.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB48080/66A GB1155310A (en) 1966-10-26 1966-10-26 Process for Increasing the Yield of Tylosin Produced by Fermentation of Microorganisms.

Publications (1)

Publication Number Publication Date
GB1155310A true GB1155310A (en) 1969-06-18

Family

ID=10447304

Family Applications (1)

Application Number Title Priority Date Filing Date
GB48080/66A Expired GB1155310A (en) 1966-10-26 1966-10-26 Process for Increasing the Yield of Tylosin Produced by Fermentation of Microorganisms.

Country Status (1)

Country Link
GB (1) GB1155310A (en)

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