GB948638A - New antibiotic and process for its manufacture - Google Patents
New antibiotic and process for its manufactureInfo
- Publication number
- GB948638A GB948638A GB2586160A GB2586160A GB948638A GB 948638 A GB948638 A GB 948638A GB 2586160 A GB2586160 A GB 2586160A GB 2586160 A GB2586160 A GB 2586160A GB 948638 A GB948638 A GB 948638A
- Authority
- GB
- United Kingdom
- Prior art keywords
- avilamycin
- water
- extraction
- organic solvent
- absolute ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
Abstract
<FORM:0948638/C2/1> <FORM:0948638/C2/2> The new antibiotic Avilamycin is a neutral substanc forming colourless crystals melting at 188-189.5 DEG C., has optical rotations <FORM:0948638/C2/3> =+0.8 DEG (C=1.165) in absolute ethanol and <FORM:0948638/C2/4> =-7.7 DEG (C=1.083) in chloroform, has the elementary analysis C=51.24%, H=6.54%, Cl=4.93%, O(Calc.)=37.29%, CH3O=8.79%, C(CH3)=8.97%, active H=0.68%, contains no nitrogen or sulphur, has a molecular weight of 708 and probable formula C31 H47O17Cl, exhibits in absolute ethanol the UV-spectrum shown in Fig. 1 and in potassium bromide the IR-spectrum shown in Fig. 2, and yields on hydrolysis with dilute mineral acid three sugar-like reducing substances which exhibit in the paper chromatogram (system: n-butanol+glacial acetic acid+water 4:1:1) R values of 0.18, 0.41 and 0.52 respectively. Avilamycin may be produced by cultivating Streptomyces viridochromogenes NRRL2860 or an Avilamycin-producing mutant thereof in a nutrient solution until the medium exhibits a substantial antibacterial activity and then isolating Avilamycin e.g. by extraction with a water-immiscible organic solvent or by adsorption, e.g. on carbon or fuller's earth followed by extraction with an at least partly water-soluble organic solvent. Pharmaceutical preparations comprising Avilamycin and a pharmaceutical carrier are suitable for enteral, parenteral or local administration and may be in the form of tablets, dragees, powders, ointments, creams, suppositories, solutions, suspensions or emulsions.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH7611459A CH374148A (en) | 1959-07-23 | 1959-07-23 | Process for the production of a new antibiotic |
| CH534260 | 1960-05-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB948638A true GB948638A (en) | 1964-02-05 |
Family
ID=25697495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2586160A Expired GB948638A (en) | 1959-07-23 | 1960-07-25 | New antibiotic and process for its manufacture |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB948638A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2133286A (en) * | 1983-01-17 | 1984-07-25 | Lilly Co Eli | Use of avilamycin to control swine dysentery |
| CN112080537A (en) * | 2020-08-03 | 2020-12-15 | 河北圣雪大成制药有限责任公司 | Method for reducing content of by-products in avilamycin fermentation liquor |
| CN114539336A (en) * | 2022-01-24 | 2022-05-27 | 河北圣雪大成制药有限责任公司 | Purification method of avilamycin A |
-
1960
- 1960-07-25 GB GB2586160A patent/GB948638A/en not_active Expired
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2133286A (en) * | 1983-01-17 | 1984-07-25 | Lilly Co Eli | Use of avilamycin to control swine dysentery |
| CN112080537A (en) * | 2020-08-03 | 2020-12-15 | 河北圣雪大成制药有限责任公司 | Method for reducing content of by-products in avilamycin fermentation liquor |
| CN112080537B (en) * | 2020-08-03 | 2023-10-27 | 河北圣雪大成制药有限责任公司 | Method for reducing byproduct content in avilamycin fermentation liquor |
| CN114539336A (en) * | 2022-01-24 | 2022-05-27 | 河北圣雪大成制药有限责任公司 | Purification method of avilamycin A |
| CN114539336B (en) * | 2022-01-24 | 2023-06-30 | 河北圣雪大成制药有限责任公司 | Purifying method of avilamycin A |
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