GB949473A - Two new antibiotics and mixtures thereof and a process for their manufacture - Google Patents

Two new antibiotics and mixtures thereof and a process for their manufacture

Info

Publication number
GB949473A
GB949473A GB17947/60A GB1794760A GB949473A GB 949473 A GB949473 A GB 949473A GB 17947/60 A GB17947/60 A GB 17947/60A GB 1794760 A GB1794760 A GB 1794760A GB 949473 A GB949473 A GB 949473A
Authority
GB
United Kingdom
Prior art keywords
lankavamycin
antibiotic
lankavacidin
forms
pict
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17947/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH7340059A external-priority patent/CH374147A/en
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB949473A publication Critical patent/GB949473A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

<PICT:0949473/C2/1> <PICT:0949473/C2/2> The antibiotics lankavamycin or lankavacidin or a mixture thereof are produced by cultivating Streptomyces violaceo-niger NRRL 2834 or a lankavamycin and/or lankavicidin-producing mutant thereof under aerobic conditions in an aqueous nutrient solution containing inorganic salts and a source of carbon and of nitrogen until the nutrient solution shows a substantial antibiotic activity, and the antibiotic lankavamycin and/or the antibiotic lankavacidin is/are then isolated. The antibiotic(s) may be extracted from the culture filtrate with an organic solvent immiscible with water and purified by adsorption and extraction from the adsorbate, by distribution between an alcoholic aqueous solution and an organic solvent immiscible with water or by chromotography. Lankavamycin forms colourless crystals which show a double melting point at 147-150 DEG C. and at 181-182 DEG C., [a ]20D=-93.8 DEG (C=1.23 in ethanol), elementary analysis C=60.18%, H=8.75%, O=31.06%, CH3CO=11.49%, OCH3=8.67%, (C)CH3=20.54%. The ultra-violet absorption spectrum shows a maximum at 289 mm (log e=1.50) and the infrared spectrum in potassium bromide is shown in Fig. 1. Lancavacidin forms pale yellow crystals which melt at 165-168 DEG C. and give a green colour reaction with ferric chloride solution. Elementary analysis gives C=62.71%, H=7.11%, N=2.87%, (C)CH3=12.60%. [a ]20D=-161 DEG (C=0.967 in absolute ethanol). The ultraviolet absorption spectrum shows a maximum at 227 mm (log e 1%=2.95) and the infrared spectrum 1 cm. in potassium bromide is shown in Fig. 2. Pharmaceutical preparations comprise lankavamycin and/or lankavacidin in admixture or conjunction with a pharmaceutical carrier in forms such as tablets, dragees, ampoules, salves, creams, powders, suppositories, solutions, suspensions or emulsions.
GB17947/60A 1959-05-20 1960-05-20 Two new antibiotics and mixtures thereof and a process for their manufacture Expired GB949473A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH7340059A CH374147A (en) 1959-05-20 1959-05-20 Process for the production of a new antibiotic
CH127660 1960-02-05

Publications (1)

Publication Number Publication Date
GB949473A true GB949473A (en) 1964-02-12

Family

ID=25687181

Family Applications (1)

Application Number Title Priority Date Filing Date
GB17947/60A Expired GB949473A (en) 1959-05-20 1960-05-20 Two new antibiotics and mixtures thereof and a process for their manufacture

Country Status (2)

Country Link
FR (1) FR350M (en)
GB (1) GB949473A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011080739A3 (en) * 2009-12-29 2011-10-20 Yeda Research And Development Co. Ltd. Synergistic antibiotic combinations and derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011080739A3 (en) * 2009-12-29 2011-10-20 Yeda Research And Development Co. Ltd. Synergistic antibiotic combinations and derivatives
US20120316106A1 (en) * 2009-12-29 2012-12-13 Yeda Research And Development Co. Ltd. Synergistic antibiotic combinations and derivatives

Also Published As

Publication number Publication date
FR350M (en) 1961-03-27

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