GB1150293A - An Aspergillopeptidase for Use in Therapy and a Process for the Preparation Thereof. - Google Patents
An Aspergillopeptidase for Use in Therapy and a Process for the Preparation Thereof.Info
- Publication number
- GB1150293A GB1150293A GB36836/66A GB3683666A GB1150293A GB 1150293 A GB1150293 A GB 1150293A GB 36836/66 A GB36836/66 A GB 36836/66A GB 3683666 A GB3683666 A GB 3683666A GB 1150293 A GB1150293 A GB 1150293A
- Authority
- GB
- United Kingdom
- Prior art keywords
- molecular weight
- aspergillopeptidase
- solution
- stable
- enzymatic activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 229920002307 Dextran Polymers 0.000 abstract 3
- 230000002255 enzymatic effect Effects 0.000 abstract 3
- 238000002523 gelfiltration Methods 0.000 abstract 3
- 102000001554 Hemoglobins Human genes 0.000 abstract 2
- 108010054147 Hemoglobins Proteins 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 239000003480 eluent Substances 0.000 abstract 2
- 238000005194 fractionation Methods 0.000 abstract 2
- 230000007935 neutral effect Effects 0.000 abstract 2
- 239000008363 phosphate buffer Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 abstract 1
- 239000005695 Ammonium acetate Substances 0.000 abstract 1
- 240000006439 Aspergillus oryzae Species 0.000 abstract 1
- 235000002247 Aspergillus oryzae Nutrition 0.000 abstract 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
- 102000011632 Caseins Human genes 0.000 abstract 1
- 108010076119 Caseins Proteins 0.000 abstract 1
- 102000009123 Fibrin Human genes 0.000 abstract 1
- 108010073385 Fibrin Proteins 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000004793 Polystyrene Substances 0.000 abstract 1
- 101710180319 Protease 1 Proteins 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 101710137710 Thioesterase 1/protease 1/lysophospholipase L1 Proteins 0.000 abstract 1
- VDIQGOWLVYFDOU-UHFFFAOYSA-H [Ca+]O.[Ca+]O.[Ca+]O.[O-]P([O-])([O-])=O Chemical compound [Ca+]O.[Ca+]O.[Ca+]O.[O-]P([O-])([O-])=O VDIQGOWLVYFDOU-UHFFFAOYSA-H 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000000862 absorption spectrum Methods 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 229940024606 amino acid Drugs 0.000 abstract 1
- 229940043376 ammonium acetate Drugs 0.000 abstract 1
- 235000019257 ammonium acetate Nutrition 0.000 abstract 1
- -1 aromatic amino acids Chemical class 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 239000008366 buffered solution Substances 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 1
- 235000011010 calcium phosphates Nutrition 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 abstract 1
- 239000005018 casein Substances 0.000 abstract 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021240 caseins Nutrition 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 238000001962 electrophoresis Methods 0.000 abstract 1
- SKAWDTAMLOJQNK-LBPRGKRZSA-N ethyl N-acetyl-L-tyrosinate Chemical compound CCOC(=O)[C@@H](NC(C)=O)CC1=CC=C(O)C=C1 SKAWDTAMLOJQNK-LBPRGKRZSA-N 0.000 abstract 1
- 229950003499 fibrin Drugs 0.000 abstract 1
- 238000001502 gel electrophoresis Methods 0.000 abstract 1
- 102000034238 globular proteins Human genes 0.000 abstract 1
- 108091005896 globular proteins Proteins 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 238000004255 ion exchange chromatography Methods 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 229920005610 lignin Polymers 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229920000058 polyacrylate Polymers 0.000 abstract 1
- 229920000193 polymethacrylate Polymers 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 229920002223 polystyrene Polymers 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000002797 proteolythic effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 235000018553 tannin Nutrition 0.000 abstract 1
- 229920001864 tannin Polymers 0.000 abstract 1
- 239000001648 tannin Substances 0.000 abstract 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
- 238000005199 ultracentrifugation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
- Y10S435/815—Enzyme separation or purification by sorption
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/913—Aspergillus
- Y10S435/918—Aspergillus oryzae
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE11191/65A SE328534B (enExample) | 1965-08-27 | 1965-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1150293A true GB1150293A (en) | 1969-04-30 |
Family
ID=20293514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB36836/66A Expired GB1150293A (en) | 1965-08-27 | 1966-08-17 | An Aspergillopeptidase for Use in Therapy and a Process for the Preparation Thereof. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3509024A (enExample) |
| AT (1) | AT277454B (enExample) |
| CH (1) | CH525251A (enExample) |
| DE (1) | DE1617279C3 (enExample) |
| DK (1) | DK119790B (enExample) |
| FI (2) | FI43715C (enExample) |
| FR (1) | FR6225M (enExample) |
| GB (1) | GB1150293A (enExample) |
| IL (1) | IL26344A (enExample) |
| NL (1) | NL6612046A (enExample) |
| NO (1) | NO133235C (enExample) |
| SE (1) | SE328534B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK81193D0 (da) * | 1993-07-06 | 1993-07-06 | Novo Nordisk As | Enzym |
| GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| AU2473099A (en) * | 1998-02-13 | 1999-08-30 | National Enzyme Company | Protease-based dietary supplementation for decreasing recovery time from soft-tissue injury |
| WO2000044928A2 (en) * | 1999-01-27 | 2000-08-03 | Halaka Folim G | Materials and methods for the purification of polyelectrolytes |
| CN1617938A (zh) | 2002-01-16 | 2005-05-18 | 戴诺生物技术有限公司 | 从单个样品中分离核酸和蛋白质的方法 |
-
1965
- 1965-08-27 SE SE11191/65A patent/SE328534B/xx unknown
-
1966
- 1966-08-16 NO NO164326A patent/NO133235C/no unknown
- 1966-08-16 IL IL26344A patent/IL26344A/xx unknown
- 1966-08-17 GB GB36836/66A patent/GB1150293A/en not_active Expired
- 1966-08-19 DE DE1617279A patent/DE1617279C3/de not_active Expired
- 1966-08-22 CH CH1206566A patent/CH525251A/de not_active IP Right Cessation
- 1966-08-25 DK DK434766AA patent/DK119790B/da unknown
- 1966-08-25 AT AT805566A patent/AT277454B/de not_active IP Right Cessation
- 1966-08-26 FI FI662235A patent/FI43715C/fi active
- 1966-08-26 US US575406A patent/US3509024A/en not_active Expired - Lifetime
- 1966-08-26 NL NL6612046A patent/NL6612046A/xx unknown
- 1966-08-26 FR FR74303A patent/FR6225M/fr not_active Expired
-
1970
- 1970-08-31 FI FI702402A patent/FI45164C/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| SE328534B (enExample) | 1970-09-21 |
| AT277454B (de) | 1969-12-29 |
| FI43715B (enExample) | 1971-03-01 |
| DE1617279B2 (de) | 1979-08-09 |
| DE1617279A1 (de) | 1971-02-18 |
| FR6225M (enExample) | 1968-08-05 |
| DK119790B (da) | 1971-02-22 |
| FI45164B (enExample) | 1971-12-31 |
| US3509024A (en) | 1970-04-28 |
| NO133235C (enExample) | 1976-03-31 |
| IL26344A (en) | 1970-01-29 |
| DE1617279C3 (de) | 1980-04-24 |
| FI43715C (fi) | 1971-06-10 |
| NL6612046A (enExample) | 1967-02-28 |
| FI45164C (fi) | 1972-04-10 |
| CH525251A (de) | 1972-07-15 |
| NO133235B (enExample) | 1975-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |