GB1149212A - Process for the production of substituted pyrimidines - Google Patents

Process for the production of substituted pyrimidines

Info

Publication number
GB1149212A
GB1149212A GB3038366A GB3038366A GB1149212A GB 1149212 A GB1149212 A GB 1149212A GB 3038366 A GB3038366 A GB 3038366A GB 3038366 A GB3038366 A GB 3038366A GB 1149212 A GB1149212 A GB 1149212A
Authority
GB
United Kingdom
Prior art keywords
formula
mole
cyanate
july
aromatic radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3038366A
Inventor
Ernst Grigat
Rolf Putter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1149212A publication Critical patent/GB1149212A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,149,212. Substituted pyrimidines. FARBENFABRIKEN BAYER A.G. 6 July, 1966 [24 July, 1965; 28 July, 1965], No. 30383/66. Heading C2C. Compounds of the formula wherein R and R<SP>1</SP> are halogenoalkyl, an aromatic or substituted aromatic radical or an aromatic radical which is fused to heterocyclic rings and Y is oxygen or an NH group, may be obtained by reacting in one or more steps 2 mols of a cyanate of the formula ROCN with 1 mole of a nitrile of the formula NO-CH 2 -X where X is -CN or -COOR<SP>2</SP> where R<SP>2</SP> is an aliphatic or aromatic radical, at temperatures of 0-120‹ C., optionally in the presence of a base, and the reaction may be effected in an inert liquid organic medium. When the reaction is effected in two stages, 1 mole of the cyanate ROCN is reacted with 1 mole of the nitrile NC-CH 2 -X to give an intermediate of the formula which is subsequently reacted with 1 mole of a cyanate R<SP>1</SP>OCN. The malonitrile starting material (i.e. when X = CN in the above formula) may be employed in the form of one of its salts.
GB3038366A 1965-07-24 1966-07-06 Process for the production of substituted pyrimidines Expired GB1149212A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEF0046709 1965-07-24
DEF0046739 1965-07-28

Publications (1)

Publication Number Publication Date
GB1149212A true GB1149212A (en) 1969-04-16

Family

ID=25976887

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3038366A Expired GB1149212A (en) 1965-07-24 1966-07-06 Process for the production of substituted pyrimidines

Country Status (5)

Country Link
BE (1) BE684392A (en)
CH (2) CH475259A (en)
DE (2) DE1545839A1 (en)
GB (1) GB1149212A (en)
IT (1) IT1058252B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2285045A (en) * 1993-12-27 1995-06-28 Shell Int Research Herbicidal pyrazines and pyrimidines

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100233068B1 (en) * 1991-11-26 1999-12-01 하인즈 모제르 Process for the preparation of 2-substituted 4,6-dialkoxypyrimidine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2285045A (en) * 1993-12-27 1995-06-28 Shell Int Research Herbicidal pyrazines and pyrimidines

Also Published As

Publication number Publication date
DE1545843A1 (en) 1969-10-23
IT1058252B (en) 1982-04-10
CH475259A (en) 1969-07-15
DE1545839A1 (en) 1969-10-16
CH475260A (en) 1969-07-15
BE684392A (en) 1967-01-20

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