GB1142474A - Production of piperidino-butyrophenones - Google Patents

Production of piperidino-butyrophenones

Info

Publication number
GB1142474A
GB1142474A GB1244865A GB1244865A GB1142474A GB 1142474 A GB1142474 A GB 1142474A GB 1244865 A GB1244865 A GB 1244865A GB 1244865 A GB1244865 A GB 1244865A GB 1142474 A GB1142474 A GB 1142474A
Authority
GB
United Kingdom
Prior art keywords
reacting
bromobenzene
march
products
addition salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1244865A
Inventor
Sven Erik Harry Hernestam
Nils Olov Bruno Sterner
Jorgen Buus Lassen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia Animal Health Inc
Original Assignee
Ferrosan AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan AB filed Critical Ferrosan AB
Priority to GB1244865A priority Critical patent/GB1142474A/en
Priority to BR16975165A priority patent/BR6569751D0/en
Priority to NO16214066A priority patent/NO122527B/no
Priority to SE350666A priority patent/SE332983B/xx
Priority to CH393666A priority patent/CH478120A/en
Priority to ES0324501A priority patent/ES324501A1/en
Priority to LU50736A priority patent/LU50736A1/xx
Priority to FI74266A priority patent/FI47765C/en
Priority to FR54697A priority patent/FR1497478A/en
Priority to NL6603798A priority patent/NL6603798A/xx
Priority to DK151266A priority patent/DK129934B/en
Priority to BE678361D priority patent/BE678361A/xx
Priority to BE683541D priority patent/BE683541A/xx
Publication of GB1142474A publication Critical patent/GB1142474A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catching Or Destruction (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1,142,474. Piperidine derivatives. FERROSAN A.B. 21 March, 1966 [24 March, 1965], No. 12448/65. Heading C2C. Piperidine derivatives of the formula wherein R 1 is a C 1-5 straight or branched alkyl group and R 2 is a hydrogen or fluorine atom, and their pharmacologically acceptable addition salts, are obtained by reacting 4-alkylpiperidinobutyro nitriles, esters or halides with (a) Grignard reagents obtained by reacting magnesium with bromobenzene or p-fluoro-bromobenzene, or with (b) the corresponding diphenyl cadmium compounds obtainable by reacting the Grignard reagents with cadmium chloride or bromide, hydrolysing the products with water and, if desired, converting the products into addition salts.
GB1244865A 1965-03-24 1965-03-24 Production of piperidino-butyrophenones Expired GB1142474A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
GB1244865A GB1142474A (en) 1965-03-24 1965-03-24 Production of piperidino-butyrophenones
BR16975165A BR6569751D0 (en) 1965-03-24 1965-05-19 PROCESS TO PREPARE BASIC KETONES
NO16214066A NO122527B (en) 1965-03-24 1966-03-16
SE350666A SE332983B (en) 1965-03-24 1966-03-16
CH393666A CH478120A (en) 1965-03-24 1966-03-18 Process for the production of basic ketones with pharmacologically valuable properties
ES0324501A ES324501A1 (en) 1965-03-24 1966-03-22 Procedure for the preparation of basic butirophenones. (Machine-translation by Google Translate, not legally binding)
LU50736A LU50736A1 (en) 1965-03-24 1966-03-23
FI74266A FI47765C (en) 1965-03-24 1966-03-23 Process for the preparation of - (4-alkylpiperidino) -p-F-butyrophenones having valuable pharmacological properties.
FR54697A FR1497478A (en) 1965-03-24 1966-03-23 Process for preparing basic ketones
NL6603798A NL6603798A (en) 1965-03-24 1966-03-23
DK151266A DK129934B (en) 1965-03-24 1966-03-23 Analogous process for the preparation of basic ketones or acid addition salts thereof.
BE678361D BE678361A (en) 1965-03-24 1966-03-24
BE683541D BE683541A (en) 1965-03-24 1966-07-01

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1244865A GB1142474A (en) 1965-03-24 1965-03-24 Production of piperidino-butyrophenones

Publications (1)

Publication Number Publication Date
GB1142474A true GB1142474A (en) 1969-02-05

Family

ID=10004786

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1244865A Expired GB1142474A (en) 1965-03-24 1965-03-24 Production of piperidino-butyrophenones

Country Status (11)

Country Link
BE (2) BE678361A (en)
BR (1) BR6569751D0 (en)
CH (1) CH478120A (en)
DK (1) DK129934B (en)
ES (1) ES324501A1 (en)
FI (1) FI47765C (en)
GB (1) GB1142474A (en)
LU (1) LU50736A1 (en)
NL (1) NL6603798A (en)
NO (1) NO122527B (en)
SE (1) SE332983B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070473A (en) * 1973-01-26 1978-01-24 Ab Ferrosan Piperidino-butyrophenones
JPS54125630A (en) * 1978-02-22 1979-09-29 Nippon Zoki Pharmaceutical Co Novel propanone derivative*its manufacture and medical composition containing it as active component

Also Published As

Publication number Publication date
NL6603798A (en) 1966-09-26
FI47765C (en) 1974-03-11
ES324501A1 (en) 1967-05-01
NO122527B (en) 1971-07-12
DK129934B (en) 1974-12-02
CH478120A (en) 1969-09-15
BE683541A (en) 1966-12-16
BR6569751D0 (en) 1973-08-16
FI47765B (en) 1973-11-30
BE678361A (en) 1966-09-01
LU50736A1 (en) 1966-05-23
SE332983B (en) 1971-03-01
DK129934C (en) 1975-05-12

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