ES324501A1 - Procedure for the preparation of basic butirophenones. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of basic butirophenones. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES324501A1
ES324501A1 ES0324501A ES324501A ES324501A1 ES 324501 A1 ES324501 A1 ES 324501A1 ES 0324501 A ES0324501 A ES 0324501A ES 324501 A ES324501 A ES 324501A ES 324501 A1 ES324501 A1 ES 324501A1
Authority
ES
Spain
Prior art keywords
basic
translation
preparation
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0324501A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia Animal Health Inc
Original Assignee
Ferrosan AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan AB filed Critical Ferrosan AB
Publication of ES324501A1 publication Critical patent/ES324501A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Catching Or Destruction (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Process for the preparation of pharmacologically active basic butyrophenones having the general formula: ** (See formula) ** wherein R1 is a linear or branched alkyl group containing from 1 to 5 carbon atoms and R2 is hydrogen or fluorine, characterized in that it is subjected to reaction to an ester of the piperidino butyronitrile or a halide, the piperidino group of which is substituted in the 4- position by a linear or branched alkyl group having from 1 to 5 carbon atoms, with a Grignard compound obtained by the reaction of magnesium with bromobenzene which can be substituted in the p-position by fluorine; and because the magnesium complex obtained is decomposed with the help of water and the isolated basic ketone. (Machine-translation by Google Translate, not legally binding)
ES0324501A 1965-03-24 1966-03-22 Procedure for the preparation of basic butirophenones. (Machine-translation by Google Translate, not legally binding) Expired ES324501A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1244865A GB1142474A (en) 1965-03-24 1965-03-24 Production of piperidino-butyrophenones

Publications (1)

Publication Number Publication Date
ES324501A1 true ES324501A1 (en) 1967-05-01

Family

ID=10004786

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0324501A Expired ES324501A1 (en) 1965-03-24 1966-03-22 Procedure for the preparation of basic butirophenones. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
BE (2) BE678361A (en)
BR (1) BR6569751D0 (en)
CH (1) CH478120A (en)
DK (1) DK129934B (en)
ES (1) ES324501A1 (en)
FI (1) FI47765C (en)
GB (1) GB1142474A (en)
LU (1) LU50736A1 (en)
NL (1) NL6603798A (en)
NO (1) NO122527B (en)
SE (1) SE332983B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070473A (en) * 1973-01-26 1978-01-24 Ab Ferrosan Piperidino-butyrophenones
JPS54125630A (en) * 1978-02-22 1979-09-29 Nippon Zoki Pharmaceutical Co Novel propanone derivative*its manufacture and medical composition containing it as active component

Also Published As

Publication number Publication date
NL6603798A (en) 1966-09-26
FI47765C (en) 1974-03-11
NO122527B (en) 1971-07-12
GB1142474A (en) 1969-02-05
DK129934B (en) 1974-12-02
CH478120A (en) 1969-09-15
BE683541A (en) 1966-12-16
BR6569751D0 (en) 1973-08-16
FI47765B (en) 1973-11-30
BE678361A (en) 1966-09-01
LU50736A1 (en) 1966-05-23
SE332983B (en) 1971-03-01
DK129934C (en) 1975-05-12

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