GB1138754A - 6-oxo-diazepine derivatives - Google Patents
6-oxo-diazepine derivativesInfo
- Publication number
- GB1138754A GB1138754A GB1511366A GB1511366A GB1138754A GB 1138754 A GB1138754 A GB 1138754A GB 1511366 A GB1511366 A GB 1511366A GB 1511366 A GB1511366 A GB 1511366A GB 1138754 A GB1138754 A GB 1138754A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chloro
- phenyl
- compound
- tetrahydro
- methylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CVLAEJNQNKXNNN-UHFFFAOYSA-N diazepin-4-one Chemical class O=C1C=CC=NN=C1 CVLAEJNQNKXNNN-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 6
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- PQJJJMRNHATNKG-UHFFFAOYSA-N ethyl bromoacetate Chemical compound CCOC(=O)CBr PQJJJMRNHATNKG-UHFFFAOYSA-N 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 abstract 1
- JXYPNRIYAMXJSE-UHFFFAOYSA-N 1,4-diazepin-6-one Chemical compound O=C1C=NC=CN=C1 JXYPNRIYAMXJSE-UHFFFAOYSA-N 0.000 abstract 1
- OMDGWOGDTCKDDE-UHFFFAOYSA-N 1-(5-chloro-2-nitrophenyl)-3,4-dihydroisoquinoline Chemical compound [N+](=O)([O-])C1=C(C=C(C=C1)Cl)C1=NCCC2=CC=CC=C12 OMDGWOGDTCKDDE-UHFFFAOYSA-N 0.000 abstract 1
- RWJBFJLEXBYILC-UHFFFAOYSA-N 2-[1-(2-amino-5-chlorophenyl)-3,4-dihydro-1H-isoquinolin-2-yl]acetic acid Chemical compound NC1=C(C=C(C=C1)Cl)C1N(CCC2=CC=CC=C12)CC(=O)O RWJBFJLEXBYILC-UHFFFAOYSA-N 0.000 abstract 1
- QQLLVIINSPOPAK-UHFFFAOYSA-N 2-[1-[5-chloro-2-(methylamino)phenyl]-3,4-dihydro-1H-isoquinolin-2-yl]acetic acid Chemical compound CNC1=C(C=C(C=C1)Cl)C1N(CCC2=CC=CC=C12)CC(=O)O QQLLVIINSPOPAK-UHFFFAOYSA-N 0.000 abstract 1
- ZSHFBENBNVFADN-UHFFFAOYSA-N 4-chloro-2-(3,4-dihydroisoquinolin-1-yl)-N-methylaniline Chemical compound CNC1=C(C=C(Cl)C=C1)C1=NCCC2=CC=CC=C12 ZSHFBENBNVFADN-UHFFFAOYSA-N 0.000 abstract 1
- ZYUYCUXFKGUOSP-UHFFFAOYSA-N 5-chloro-2-nitrobenzoyl chloride Chemical compound [O-][N+](=O)C1=CC=C(Cl)C=C1C(Cl)=O ZYUYCUXFKGUOSP-UHFFFAOYSA-N 0.000 abstract 1
- FKTQNWWDMJDNHA-UHFFFAOYSA-N 6-chloro-1-methyl-3,1-benzoxazine-2,4-dione Chemical compound C1=C(Cl)C=C2C(=O)OC(=O)N(C)C2=C1 FKTQNWWDMJDNHA-UHFFFAOYSA-N 0.000 abstract 1
- 241000416162 Astragalus gummifer Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Natural products NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 208000010513 Stupor Diseases 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical class [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 229920001615 Tragacanth Polymers 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229940025084 amphetamine Drugs 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 229940125717 barbiturate Drugs 0.000 abstract 1
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 abstract 1
- 125000005605 benzo group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000011928 denatured alcohol Substances 0.000 abstract 1
- 229940102223 injectable solution Drugs 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 238000007040 multi-step synthesis reaction Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- -1 p-toluenesulphonyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940117803 phenethylamine Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 235000012222 talc Nutrition 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 235000010487 tragacanth Nutrition 0.000 abstract 1
- 239000000196 tragacanth Substances 0.000 abstract 1
- 229940116362 tragacanth Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44752265A | 1965-04-12 | 1965-04-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1138754A true GB1138754A (en) | 1969-01-01 |
Family
ID=23776703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1511366A Expired GB1138754A (en) | 1965-04-12 | 1966-04-05 | 6-oxo-diazepine derivatives |
Country Status (3)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000044725A1 (de) * | 1999-01-28 | 2000-08-03 | Boehringer Ingelheim Pharma Kg | Anellierte dihydropyridine und verwendung von anellierten dihydropyridinen für die herstellung von mitteln für die behandlung von epilepsie |
-
1966
- 1966-04-05 GB GB1511366A patent/GB1138754A/en not_active Expired
- 1966-04-11 ES ES0325366A patent/ES325366A1/es not_active Expired
- 1966-07-11 FR FR68963A patent/FR5542M/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000044725A1 (de) * | 1999-01-28 | 2000-08-03 | Boehringer Ingelheim Pharma Kg | Anellierte dihydropyridine und verwendung von anellierten dihydropyridinen für die herstellung von mitteln für die behandlung von epilepsie |
Also Published As
| Publication number | Publication date |
|---|---|
| ES325366A1 (es) | 1967-04-01 |
| FR5542M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-11-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1222708A (en) | Novel 5-(n-substituted aminomethyl)-2-oxazolidinones and their process of preparation | |
| GB1314903A (en) | Quinazoline derivatives | |
| EP1095015B1 (de) | Sulfonylamino-carbonsäure-n-arylamide als guanylatcyclase-aktivatoren | |
| GB1153977A (en) | 9-Cycloalkyl-Lower Alkyl-Piperidylidene Derivatives of Xanthenes and Thioxanthenes | |
| GB1229651A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| GB1138754A (en) | 6-oxo-diazepine derivatives | |
| GB1173227A (en) | Amino-Isoquinolines | |
| GB1256750A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| GB1248430A (en) | 4-phenyl-quinazolinone derivatives | |
| GB1495665A (en) | Pyrimidines | |
| GB1425578A (en) | Piperidine derivatives | |
| KR950005307A (ko) | 약제학적 조성물 | |
| GB1529251A (en) | 9,10-dihydroergopeptines | |
| GB1123768A (en) | New thebaine and oripavine derivatives and processes for preparing the same | |
| GB1198931A (en) | Benzoxazine Derivatives, the preparation thereof and Compositions containing the same | |
| GB1226116A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| GB1354216A (en) | Substituted isoquinolines and a process for the preparation thereof | |
| GB1417539A (en) | Pyrazolo-qzinoline derivative and compositions thereof | |
| HU185303B (en) | Process for preparing new eburnane derivatives | |
| US3760082A (en) | Compositions containing 5-amino-3-ethyl-1-phenyl-4-pyrazolecarboxamides and methods of using the same | |
| GB1327552A (en) | 1-substituted benzyl tetrahydro-2-1h-pyrimidones and their preparation | |
| GB1254270A (en) | Benzoxazepine derivatives | |
| GB1276719A (en) | Benzomorphan derivatives and their salts | |
| ES451866A1 (es) | Procedimiento para la preparacion de nuevos 4-hidroxi-2h-nafto-(2, 1-e)-1, 2-tiazin-3-carboxamido-1, 1-dioxidos. | |
| GB1311004A (en) | Dibenzocycloheptenes |