GB1137655A - Process for producing new 5-nitroimidazole ethers - Google Patents
Process for producing new 5-nitroimidazole ethersInfo
- Publication number
- GB1137655A GB1137655A GB20988/67A GB2098867A GB1137655A GB 1137655 A GB1137655 A GB 1137655A GB 20988/67 A GB20988/67 A GB 20988/67A GB 2098867 A GB2098867 A GB 2098867A GB 1137655 A GB1137655 A GB 1137655A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- radical
- nitroimidazole
- nitroimidazoles
- ethers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 5-nitroimidazole ethers Chemical class 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000004958 5-nitroimidazoles Chemical class 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940058965 antiprotozoal agent against amoebiasis and other protozoal diseases nitroimidazole derivative Drugs 0.000 abstract 1
- 150000005840 aryl radicals Chemical group 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- YNGRGHODNDCZCC-UHFFFAOYSA-N nitro hydrogen sulfate Chemical group OS(=O)(=O)O[N+]([O-])=O YNGRGHODNDCZCC-UHFFFAOYSA-N 0.000 abstract 1
- 150000004957 nitroimidazoles Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/93—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by halogen atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
- C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C21—METALLURGY OF IRON
- C21C—PROCESSING OF PIG-IRON, e.g. REFINING, MANUFACTURE OF WROUGHT-IRON OR STEEL; TREATMENT IN MOLTEN STATE OF FERROUS ALLOYS
- C21C7/00—Treating molten ferrous alloys, e.g. steel, not covered by groups C21C1/00 - C21C5/00
- C21C7/0025—Adding carbon material
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,137,655. Nitroimidazole derivatives. KRKA TOVARNA ZDRAVIL. 5 May, 1967 [7 May, 1966], No. 20988/67. Heading C2C. 5-Nitroimidazoles of the formula wherein R is a hydrogen atom or an alkyl or aryl radical, A is a bivalent aliphatic hydrocarbon radical, B is a bivalent aliphatic or aromatic hydrocarbon radical and X is a hydrogen or halogen atom or a nitro, sulphuric acid, sulphonic acid or hydroxyl group, are obtained by condensing compounds of the formula wherein Z is a reactive ester radical, with the appropriate 4(5)-nitroimidazoles under anhydrous conditions in the presence of acid catalysts, and treating the salts so obtained with bases to obtain the free imidazoles. The compounds of the above formula have chemotherapeutic properties.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU84566 | 1966-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1137655A true GB1137655A (en) | 1968-12-27 |
Family
ID=25551678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20988/67A Expired GB1137655A (en) | 1966-05-07 | 1967-05-05 | Process for producing new 5-nitroimidazole ethers |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT268273B (en) |
| BE (1) | BE698066A (en) |
| CH (1) | CH462180A (en) |
| DE (1) | DE1720042A1 (en) |
| DK (1) | DK119060B (en) |
| FR (1) | FR1522671A (en) |
| GB (1) | GB1137655A (en) |
| NL (1) | NL6706373A (en) |
| SE (1) | SE314380B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114605332A (en) * | 2022-03-02 | 2022-06-10 | 潍坊富邦药业有限公司 | Preparation process of metronidazole |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2414280C2 (en) * | 1974-03-25 | 1981-12-17 | Basf Ag, 6700 Ludwigshafen | Process for the preparation of 1-methyl-5-nitroimidazoles |
| EP0001654B1 (en) * | 1977-10-13 | 1981-07-22 | Siegfried Aktiengesellschaft | Imidazolylethylene-oxyalkyloxy derivatives and their thio analogues, methods for their preparation and pharmaceutical compositions containing them |
| DE4110866C2 (en) * | 1991-04-04 | 1994-06-16 | Teves Gmbh Alfred | Mounting device for mounting an elastic sealing ring |
-
1967
- 1967-05-05 AT AT419267A patent/AT268273B/en active
- 1967-05-05 BE BE698066D patent/BE698066A/xx unknown
- 1967-05-05 DK DK237767AA patent/DK119060B/en unknown
- 1967-05-05 GB GB20988/67A patent/GB1137655A/en not_active Expired
- 1967-05-05 NL NL6706373A patent/NL6706373A/xx unknown
- 1967-05-05 CH CH640367A patent/CH462180A/en unknown
- 1967-05-05 DE DE19671720042 patent/DE1720042A1/en active Pending
- 1967-05-05 FR FR105291A patent/FR1522671A/en not_active Expired
- 1967-05-08 SE SE6437/67A patent/SE314380B/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114605332A (en) * | 2022-03-02 | 2022-06-10 | 潍坊富邦药业有限公司 | Preparation process of metronidazole |
| CN114605332B (en) * | 2022-03-02 | 2024-03-12 | 潍坊富邦药业有限公司 | Preparation process of metronidazole |
Also Published As
| Publication number | Publication date |
|---|---|
| BE698066A (en) | 1967-11-06 |
| AT268273B (en) | 1969-02-10 |
| FR1522671A (en) | 1968-04-26 |
| NL6706373A (en) | 1967-11-08 |
| CH462180A (en) | 1968-09-15 |
| DK119060B (en) | 1970-11-09 |
| DE1720042A1 (en) | 1972-04-27 |
| SE314380B (en) | 1969-09-08 |
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