GB1135926A - Pharmaceutical compositions containing bisphenyl-alkenylamine derivatives - Google Patents
Pharmaceutical compositions containing bisphenyl-alkenylamine derivativesInfo
- Publication number
- GB1135926A GB1135926A GB8166/66A GB816666A GB1135926A GB 1135926 A GB1135926 A GB 1135926A GB 8166/66 A GB8166/66 A GB 8166/66A GB 816666 A GB816666 A GB 816666A GB 1135926 A GB1135926 A GB 1135926A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxypropylamine
- phenyl
- prepared
- radicals
- diphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 benzyl radicals Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- BMFSZANKMAOKCG-UHFFFAOYSA-N 3-(dimethylamino)-1-(3-fluorophenyl)-1-phenylpropan-1-ol Chemical compound CN(C)CCC(O)(C1=CC=CC=C1)C1=CC(=CC=C1)F BMFSZANKMAOKCG-UHFFFAOYSA-N 0.000 abstract 1
- HRWCYSMUGQYSMJ-UHFFFAOYSA-N 3-(methylamino)-1,1-diphenylpropan-1-ol Chemical compound C=1C=CC=CC=1C(O)(CCNC)C1=CC=CC=C1 HRWCYSMUGQYSMJ-UHFFFAOYSA-N 0.000 abstract 1
- RUOVOSKKBYNCRE-UHFFFAOYSA-N 3-amino-1,1-diphenylpropan-1-ol Chemical compound C=1C=CC=CC=1C(O)(CCN)C1=CC=CC=C1 RUOVOSKKBYNCRE-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000003747 Grignard reaction Methods 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- ANRQGKOBLBYXFM-UHFFFAOYSA-M phenylmagnesium bromide Chemical compound Br[Mg]C1=CC=CC=C1 ANRQGKOBLBYXFM-UHFFFAOYSA-M 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8166/66A GB1135926A (en) | 1966-02-24 | 1966-02-24 | Pharmaceutical compositions containing bisphenyl-alkenylamine derivatives |
| US615327A US3422203A (en) | 1966-02-24 | 1967-02-13 | Treatment of depression with diphenyl prop-2-enylamine derivatives |
| BE694631D BE694631A (zh) | 1966-02-24 | 1967-02-24 | |
| NL6702969A NL6702969A (zh) | 1966-02-24 | 1967-02-24 | |
| FR96282A FR7029M (zh) | 1965-03-01 | 1967-05-22 | |
| MY7200110A MY7200110A (en) | 1966-02-24 | 1972-12-31 | Pharmaceutical compositions containing bisphenyl-alkenylamine derivatives |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB460766 | 1966-02-24 | ||
| GB8166/66A GB1135926A (en) | 1966-02-24 | 1966-02-24 | Pharmaceutical compositions containing bisphenyl-alkenylamine derivatives |
| GB2627566 | 1966-06-13 | ||
| GB4607266 | 1966-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1135926A true GB1135926A (en) | 1968-12-11 |
Family
ID=27447388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8166/66A Expired GB1135926A (en) | 1965-03-01 | 1966-02-24 | Pharmaceutical compositions containing bisphenyl-alkenylamine derivatives |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3422203A (zh) |
| BE (1) | BE694631A (zh) |
| FR (1) | FR7029M (zh) |
| GB (1) | GB1135926A (zh) |
| NL (1) | NL6702969A (zh) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017965A (en) * | 1993-02-08 | 2000-01-25 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6051610A (en) * | 1993-02-08 | 2000-04-18 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6750244B2 (en) | 1993-02-08 | 2004-06-15 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US7087765B2 (en) | 1995-06-07 | 2006-08-08 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA525752A (en) * | 1956-06-05 | V. Petersen Poul | Antispasmodic unsaturated tertiary amines | |
| DE1122514B (de) * | 1959-09-08 | 1962-01-25 | Giulini Gmbh Geb | Verfahren zur Herstellung von blutdrucksteigerndem 2-AEthyl-3,3-diphenyl-propen-(2)-yl-amin |
| DE1203247B (de) * | 1961-10-10 | 1965-10-21 | Koninklijke Pharma Fab Nv | Verfahren zur Herstellung von Diphenylalkenyl-aminen sowie deren nicht-toxischen Salzen |
| DE1149002B (de) * | 1961-10-19 | 1963-05-22 | Giulini Gmbh Geb | Verfahren zur Herstellung von blutdrucksteigernden Salzen von N, N-Dialkyl-2-aethyl-3, 3-diphenyl-propen-(2)-yl-aminen |
-
1966
- 1966-02-24 GB GB8166/66A patent/GB1135926A/en not_active Expired
-
1967
- 1967-02-13 US US615327A patent/US3422203A/en not_active Expired - Lifetime
- 1967-02-24 NL NL6702969A patent/NL6702969A/xx unknown
- 1967-02-24 BE BE694631D patent/BE694631A/xx unknown
- 1967-05-22 FR FR96282A patent/FR7029M/fr not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6017965A (en) * | 1993-02-08 | 2000-01-25 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6051610A (en) * | 1993-02-08 | 2000-04-18 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6071970A (en) * | 1993-02-08 | 2000-06-06 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US6750244B2 (en) | 1993-02-08 | 2004-06-15 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US7268166B2 (en) | 1993-02-08 | 2007-09-11 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
| US7087765B2 (en) | 1995-06-07 | 2006-08-08 | Nps Pharmaceuticals, Inc. | Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| BE694631A (zh) | 1967-08-24 |
| US3422203A (en) | 1969-01-14 |
| NL6702969A (zh) | 1967-08-25 |
| FR7029M (zh) | 1969-06-09 |
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