GB1110734A - 9-substituted isotheophyllines - Google Patents

9-substituted isotheophyllines

Info

Publication number
GB1110734A
GB1110734A GB5040666A GB5040666A GB1110734A GB 1110734 A GB1110734 A GB 1110734A GB 5040666 A GB5040666 A GB 5040666A GB 5040666 A GB5040666 A GB 5040666A GB 1110734 A GB1110734 A GB 1110734A
Authority
GB
United Kingdom
Prior art keywords
hydroxyethyl
prepared
dimethyl
compound
action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5040666A
Inventor
Helmer Richter
Gunther Neukamm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Interpharm & Co K G GmbH
Original Assignee
Interpharm & Co K G GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Interpharm & Co K G GmbH filed Critical Interpharm & Co K G GmbH
Priority to GB5040666A priority Critical patent/GB1110734A/en
Publication of GB1110734A publication Critical patent/GB1110734A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds of general formula <FORM:1110734/C2/1> and acid addition salts thereof wherein R1 and R2 which are the same or different are H, alkyl or hydroxyalkyl or N,R1,R2 is an optionally substituted heterocyclic ring are prepared from a compound of formula <FORM:1110734/C2/2> where R3 is OH or -NR1R2 by cyclic condensation with CS2, an optionally substituted formamide or an ortho-ester of formic acid, removal of mercaptan by reduction if CS2 is used, and followed by condensation of HNR1R2 with the halide formed from any compound when R3 is OH. 9 - (b - Chloroethyl) - isotheophylline is obtained by action of thionyl chloride on 9-(b -hydroxyethyl) - theophyllin prepared by catalytic desulphurization of the 8-mercapto-9-(b -hydroxyethyl) - isotheophylline obtained by condensation of CS2 and 1,3-dimethyl-4-(b -hydroxyethyl) - 5 - aminouracil which is prepared by reduction of the corresponding 5-nitroso compound. 1,3 - Dimethyl - 4 - (b - hydroxyethyl) - 5-nitrosouracil is prepared by action of NaNO2 and acid on the 1,3-dimethyl-4-(b -hydroxyethyl)-uracil prepared by action of 4-chloro-1,3-dimethyl uracil on ethanolamine. Pharmaceutical compositions in conventional forms for oral or parenteral administration comprise an above novel compound and a pharmaceutical carrier or diluent and have choleretic activity only.
GB5040666A 1966-11-10 1966-11-10 9-substituted isotheophyllines Expired GB1110734A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB5040666A GB1110734A (en) 1966-11-10 1966-11-10 9-substituted isotheophyllines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5040666A GB1110734A (en) 1966-11-10 1966-11-10 9-substituted isotheophyllines

Publications (1)

Publication Number Publication Date
GB1110734A true GB1110734A (en) 1968-04-24

Family

ID=10455784

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5040666A Expired GB1110734A (en) 1966-11-10 1966-11-10 9-substituted isotheophyllines

Country Status (1)

Country Link
GB (1) GB1110734A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2232320A1 (en) * 1973-06-08 1975-01-03 Wuelfing Johann A 4-Amino-uracil derivs - hypocholesterolemiant having diuretic activity
EP0077896A1 (en) * 1981-08-27 1983-05-04 Miles Inc. Theophylline derivatives, antibodies and their preparation from theophylline immunogens, as well as an immuno assay method and reagent means for determining theophylline

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2232320A1 (en) * 1973-06-08 1975-01-03 Wuelfing Johann A 4-Amino-uracil derivs - hypocholesterolemiant having diuretic activity
EP0077896A1 (en) * 1981-08-27 1983-05-04 Miles Inc. Theophylline derivatives, antibodies and their preparation from theophylline immunogens, as well as an immuno assay method and reagent means for determining theophylline
US4533493A (en) * 1981-08-27 1985-08-06 Miles Laboratories, Inc. Theophylline immunogens, antibodies, labeled conjugates, and related derivatives

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