GB1100281A - New spiro-decane derivatives and process for the preparation thereof - Google Patents
New spiro-decane derivatives and process for the preparation thereofInfo
- Publication number
- GB1100281A GB1100281A GB16696/64A GB1669664A GB1100281A GB 1100281 A GB1100281 A GB 1100281A GB 16696/64 A GB16696/64 A GB 16696/64A GB 1669664 A GB1669664 A GB 1669664A GB 1100281 A GB1100281 A GB 1100281A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrogen
- prepared
- general formula
- methylene
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL127065D NL127065C (US07235543-20070626-C00016.png) | 1964-04-22 | ||
GB16696/64A GB1100281A (en) | 1964-04-22 | 1964-04-22 | New spiro-decane derivatives and process for the preparation thereof |
SE4001/65A SE307793B (US07235543-20070626-C00016.png) | 1964-04-22 | 1965-03-27 | |
DE1620262A DE1620262C3 (de) | 1964-04-22 | 1965-04-09 | Spiro [4.5] decanderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen |
NL6504602A NL6504602A (US07235543-20070626-C00016.png) | 1964-04-22 | 1965-04-12 | |
US447952A US3399192A (en) | 1964-04-22 | 1965-04-14 | 1-oxa-2-oxo 3, 8-diaza spiro (4, 5) decanes |
FR13521A FR1441575A (fr) | 1964-04-22 | 1965-04-16 | Nouveaux dérivés du spiro (4, 5) décane et leurs procédés de préparation |
BE662817A BE662817A (US07235543-20070626-C00016.png) | 1964-04-22 | 1965-04-21 | |
ES0312091A ES312091A1 (es) | 1964-04-22 | 1965-04-21 | Procedimiento de preparacion de nuevos derivados del spiro (4, 5) decano |
CH558965A CH454160A (fr) | 1964-04-22 | 1965-04-22 | Procédé de préparation de nouveaux dérivés du spiro-(4,5)-décane |
FR22211A FR4463M (US07235543-20070626-C00016.png) | 1964-04-22 | 1965-06-25 | |
ES361975A ES361975A2 (es) | 1964-04-22 | 1968-12-28 | Procedimiento de preparacion de nuevos derivados del spiro (4,5) decano |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB16696/64A GB1100281A (en) | 1964-04-22 | 1964-04-22 | New spiro-decane derivatives and process for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1100281A true GB1100281A (en) | 1968-01-24 |
Family
ID=10081982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB16696/64A Expired GB1100281A (en) | 1964-04-22 | 1964-04-22 | New spiro-decane derivatives and process for the preparation thereof |
Country Status (9)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2666583A1 (fr) * | 1990-09-06 | 1992-03-13 | Adir | Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant. |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL129025C (US07235543-20070626-C00016.png) * | 1965-04-29 | |||
US3542729A (en) * | 1968-03-19 | 1970-11-24 | Sankyo Co | Stabilization of synthetic polymers |
BE790675A (fr) * | 1971-10-29 | 1973-04-27 | Science Union & Cie | Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane |
US4244961A (en) * | 1978-10-26 | 1981-01-13 | Syntex (U.S.A.) Inc. | 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents |
US4255432A (en) * | 1979-09-06 | 1981-03-10 | Syntex (U.S.A.) Inc. | 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof |
ES517622A0 (es) * | 1982-11-23 | 1983-12-16 | Faes | Procedimiento de preparacion de un nuevo espirodecano. |
HU204054B (en) * | 1989-08-10 | 1991-11-28 | Richter Gedeon Vegyeszet | Process for producing new 1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives and pharmaceutical compositions comprising same |
YU150489A (sh) * | 1989-08-10 | 1992-12-21 | W.L. Gore & Co. Gmbh. | Uređaj za ispitivanje odevnih predmeta na nepromočivost |
FR2734265B1 (fr) * | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
CZ20032031A3 (cs) * | 2001-01-26 | 2003-12-17 | Schering Corporation | Farmaceutický prostředek |
US20020183305A1 (en) * | 2001-01-26 | 2002-12-05 | Schering Corporation | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
DE60221798T2 (de) * | 2001-01-26 | 2008-06-05 | Schering Corp. | Kombinationen von gallensäure sequestriermitteln und hemmern der sterol absorption zur behandlung von kardiovaskulären indikationen |
WO2002058734A2 (en) * | 2001-01-26 | 2002-08-01 | Schering Corporation | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
PL205343B1 (pl) * | 2001-01-26 | 2010-04-30 | Schering Corp | Zastosowanie inhibitora wchłaniania sterolu |
ES2290562T3 (es) * | 2001-01-26 | 2008-02-16 | Schering Corporation | Combinaciones del activador del receptor activado por el proliferador de los peroxisomas (ppar) fenofibrato con el inhibidor de la absorcion de esteroles ezetimiba para indicaciones vasculares. |
DE60216275T2 (de) * | 2001-05-25 | 2007-06-21 | Schering Corp. | Verwendung von mit azetidinon substituierten derivaten bei der behandlung der alzheimer-krankheit |
DE10130020A1 (de) * | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
DE10146275A1 (de) | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
EP1427409B1 (en) * | 2001-09-21 | 2008-10-15 | Schering Corporation | Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s) |
EP1429756B1 (en) * | 2001-09-21 | 2006-11-22 | Schering Corporation | Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors |
CN1681495B (zh) | 2002-08-19 | 2010-05-12 | 辉瑞产品公司 | 用于治疗过度增生性疾病的组合物 |
WO2004043456A1 (en) * | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
CA2517573C (en) * | 2003-03-07 | 2011-12-06 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
US7208486B2 (en) | 2003-03-07 | 2007-04-24 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
WO2005046797A2 (en) * | 2003-11-05 | 2005-05-26 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
BRPI0507586A (pt) | 2004-02-10 | 2007-07-03 | Hoffmann La Roche | moduladores de receptor de quimiocina ccr5 |
US20060063803A1 (en) * | 2004-09-23 | 2006-03-23 | Pfizer Inc | 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
US8383660B2 (en) | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
AU2008233930A1 (en) * | 2007-03-29 | 2008-10-09 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CN102766147B (zh) * | 2012-08-03 | 2015-07-15 | 无锡药兴医药科技有限公司 | 一种芬司匹利及其氢卤酸盐的制备方法 |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
WO2014170786A1 (en) | 2013-04-17 | 2014-10-23 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
GB201416346D0 (en) * | 2014-09-16 | 2014-10-29 | Shire Internat Gmbh | Spirocyclic derivatives |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
CN113574055A (zh) | 2019-01-18 | 2021-10-29 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3193559A (en) * | 1965-07-06 | New derivatives of z-oxazolidinones | ||
US2437388A (en) * | 1948-03-09 | Z-oxazolidone compounds and proc | ||
US2500714A (en) * | 1944-10-30 | 1950-03-14 | Abbott Lab | 4-phenyl-1-alkyl isonipecotic acid lactones |
US3054794A (en) * | 1958-01-17 | 1962-09-18 | Us Vitamin Pharm Corp | Process for preparing 3-(aminoalkyl)-oxazolidine-2, 4-diones |
GB974134A (en) * | 1963-03-28 | 1964-11-04 | Science Union Et Compagnie Soc | Oxazolidinone derivatives |
-
0
- NL NL127065D patent/NL127065C/xx active
-
1964
- 1964-04-22 GB GB16696/64A patent/GB1100281A/en not_active Expired
-
1965
- 1965-03-27 SE SE4001/65A patent/SE307793B/xx unknown
- 1965-04-09 DE DE1620262A patent/DE1620262C3/de not_active Expired
- 1965-04-12 NL NL6504602A patent/NL6504602A/xx unknown
- 1965-04-14 US US447952A patent/US3399192A/en not_active Expired - Lifetime
- 1965-04-16 FR FR13521A patent/FR1441575A/fr not_active Expired
- 1965-04-21 ES ES0312091A patent/ES312091A1/es not_active Expired
- 1965-04-21 BE BE662817A patent/BE662817A/xx unknown
- 1965-04-22 CH CH558965A patent/CH454160A/fr unknown
- 1965-06-25 FR FR22211A patent/FR4463M/fr not_active Expired
-
1968
- 1968-12-28 ES ES361975A patent/ES361975A2/es not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2666583A1 (fr) * | 1990-09-06 | 1992-03-13 | Adir | Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant. |
EP0479631A1 (fr) * | 1990-09-06 | 1992-04-08 | Adir Et Compagnie | Dérivés du spiro [4.5]décane leur procédé de préparation et les compositions pharmaceutiques les renfermant |
AU638354B2 (en) * | 1990-09-06 | 1993-06-24 | Adir Et Compagnie | New spiro(4.5)decane compounds, a process for the preparation thereof and pharmaceutical compositions containing them |
Also Published As
Publication number | Publication date |
---|---|
DE1620262C3 (de) | 1980-07-03 |
ES361975A2 (es) | 1971-01-16 |
ES312091A1 (es) | 1965-10-01 |
NL6504602A (US07235543-20070626-C00016.png) | 1965-10-25 |
DE1620262B2 (de) | 1979-10-11 |
FR4463M (US07235543-20070626-C00016.png) | 1966-09-26 |
CH454160A (fr) | 1968-04-15 |
FR1441575A (fr) | 1966-06-10 |
US3399192A (en) | 1968-08-27 |
NL127065C (US07235543-20070626-C00016.png) | |
DE1620262A1 (de) | 1972-03-23 |
BE662817A (US07235543-20070626-C00016.png) | 1965-10-21 |
SE307793B (US07235543-20070626-C00016.png) | 1969-01-20 |
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