GB1098111A - Substituted phenoxy- and phenylthio-alkanoic acids - Google Patents

Substituted phenoxy- and phenylthio-alkanoic acids

Info

Publication number
GB1098111A
GB1098111A GB10206/65A GB1020665A GB1098111A GB 1098111 A GB1098111 A GB 1098111A GB 10206/65 A GB10206/65 A GB 10206/65A GB 1020665 A GB1020665 A GB 1020665A GB 1098111 A GB1098111 A GB 1098111A
Authority
GB
United Kingdom
Prior art keywords
halogen
compounds
chy
alkoxy
similar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10206/65A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1098111A publication Critical patent/GB1098111A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Earth Drilling (AREA)
GB10206/65A 1964-03-20 1965-03-10 Substituted phenoxy- and phenylthio-alkanoic acids Expired GB1098111A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35357964A 1964-03-20 1964-03-20
US42910765A 1965-01-29 1965-01-29
US429130A US3378582A (en) 1964-03-20 1965-01-29 (alpha-phenoxy)-and (alpha-phenylthio)-omegaphenyl-alkanoic acids

Publications (1)

Publication Number Publication Date
GB1098111A true GB1098111A (en) 1968-01-03

Family

ID=27408125

Family Applications (1)

Application Number Title Priority Date Filing Date
GB10206/65A Expired GB1098111A (en) 1964-03-20 1965-03-10 Substituted phenoxy- and phenylthio-alkanoic acids

Country Status (12)

Country Link
US (1) US3378582A (enExample)
BE (1) BE661417A (enExample)
BR (2) BR6567968D0 (enExample)
CH (1) CH503688A (enExample)
DE (1) DE1543181A1 (enExample)
DK (1) DK120903B (enExample)
FR (2) FR1476525A (enExample)
GB (1) GB1098111A (enExample)
IL (1) IL23152A (enExample)
NL (1) NL147414B (enExample)
NO (1) NO119413B (enExample)
SE (1) SE338769B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304788A (en) 1978-09-08 1981-12-08 Imperial Chemical Industries Limited Hydroxyalkanoic acid derivatives
JP2008526904A (ja) * 2005-01-14 2008-07-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング ヒドロキシフェノール誘導体、その調製方法、それらを含む医薬組成物、およびその治療的使用

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH543472A (fr) * 1969-01-31 1973-10-31 Orchimed Sa Procédé pour la préparation d'acides phénoxyalcoyl-carboxyliques
NL7301246A (enExample) * 1972-02-14 1973-08-16
US3923855A (en) * 1972-07-13 1975-12-02 Merck & Co Inc 2-sulfonyloxyethyl 3-trifluoromethylphenoxy-4{40 -chlorophenyl acetate
US4168385A (en) * 1975-09-25 1979-09-18 American Cyanamid Company Hypolipemic phenylacetic acid derivatives
ZA765075B (en) * 1975-09-25 1977-08-31 American Cyanamid Co Hypolipemic compounds and method of treatment
DE2735856A1 (de) * 1977-08-09 1979-02-22 Klinge Co Chem Pharm Fab Neue 1,3-diphenoxypropan-2-on-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2460286A1 (fr) * 1979-06-29 1981-01-23 Rhone Poulenc Agrochimie Procede de preparation d'acide phenoxy-2 propioniques optiquement actifs
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US7576131B2 (en) * 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6624194B1 (en) * 1999-06-04 2003-09-23 Metabolex, Inc. Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
EP1366012A4 (en) * 2001-02-09 2005-11-02 Merck & Co Inc 2-ARYLOXY-2-ARYLALKANIC ACIDS AGAINST DIABETES AND FAILURE CHANGES
US7199259B2 (en) * 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
CA2555814A1 (en) * 2004-02-18 2005-09-01 Metabolex, Inc. Alpha-(trifluoromethyl-substituted aryloxy, arylamino, arylthio or arylmethyl)-trifluoromethyl-substituted phenylacetic acids and derivatives as antidiabetic agents
FR2869611B1 (fr) * 2004-05-03 2006-07-28 Merck Sante Soc Par Actions Si Derives de l'acide hexenoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
FR2869615B1 (fr) * 2004-05-03 2007-11-16 Merck Sante Soc Par Actions Si Derives de l'acide butanoique, procedes pour leur preparation, compositions pharmaceutiques les contenant et leurs applications therapeutiques
WO2005115384A2 (en) * 2004-05-25 2005-12-08 Metabolex, Inc. Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation
RU2006145872A (ru) * 2004-05-25 2008-06-27 Метаболекс, Инк. (Us) Замещенные триазолы в качестве модуляторов ppar и способы их получения
US7714131B2 (en) * 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
US7879911B2 (en) 2007-02-01 2011-02-01 Johnson Alan T Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304788A (en) 1978-09-08 1981-12-08 Imperial Chemical Industries Limited Hydroxyalkanoic acid derivatives
US4310544A (en) 1978-09-08 1982-01-12 Imperial Chemical Industries Limited Hydroxyacetic acid derivatives with anti-arthritic properties
JP2008526904A (ja) * 2005-01-14 2008-07-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング ヒドロキシフェノール誘導体、その調製方法、それらを含む医薬組成物、およびその治療的使用

Also Published As

Publication number Publication date
NL147414B (nl) 1975-10-15
DE1543181A1 (de) 1969-06-12
NL6503523A (enExample) 1965-09-21
IL23152A (en) 1969-06-25
FR4681M (enExample) 1966-12-19
BR6567967D0 (pt) 1973-08-07
NO119413B (enExample) 1970-05-19
DE1668938A1 (de) 1972-01-27
FR1476525A (fr) 1967-04-14
BE661417A (enExample) 1965-09-20
BR6567968D0 (pt) 1973-08-07
US3378582A (en) 1968-04-16
SE338769B (enExample) 1971-09-20
CH503688A (de) 1971-02-28
DK120903B (da) 1971-08-02

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