GB1086192A - Phenylcyclopropane derivatives - Google Patents
Phenylcyclopropane derivativesInfo
- Publication number
- GB1086192A GB1086192A GB49345/66A GB4934566A GB1086192A GB 1086192 A GB1086192 A GB 1086192A GB 49345/66 A GB49345/66 A GB 49345/66A GB 4934566 A GB4934566 A GB 4934566A GB 1086192 A GB1086192 A GB 1086192A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cis
- cyclopropane
- phenyl
- carboxylic acid
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VFSFCYAQBIPUSL-UHFFFAOYSA-N cyclopropylbenzene Chemical class C1CC1C1=CC=CC=C1 VFSFCYAQBIPUSL-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- AHDDRJBFJBDEPW-RKDXNWHRSA-N (1r,2s)-2-phenylcyclopropane-1-carboxylic acid Chemical compound OC(=O)[C@@H]1C[C@@H]1C1=CC=CC=C1 AHDDRJBFJBDEPW-RKDXNWHRSA-N 0.000 abstract 1
- SODZBMGDYKEZJG-UHFFFAOYSA-N 2-phenylcyclopropane-1-carbonyl chloride Chemical compound ClC(=O)C1CC1C1=CC=CC=C1 SODZBMGDYKEZJG-UHFFFAOYSA-N 0.000 abstract 1
- AHDDRJBFJBDEPW-UHFFFAOYSA-N 2-phenylcyclopropane-1-carboxylic acid Chemical compound OC(=O)C1CC1C1=CC=CC=C1 AHDDRJBFJBDEPW-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000002921 anti-spasmodic effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- BFAKENXZKHGIGE-UHFFFAOYSA-N bis(2,3,5,6-tetrafluoro-4-iodophenyl)diazene Chemical compound FC1=C(C(=C(C(=C1F)I)F)F)N=NC1=C(C(=C(C(=C1F)F)I)F)F BFAKENXZKHGIGE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003874 central nervous system depressant Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- -1 nitro, amino Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB43626/63A GB1086191A (en) | 1963-11-05 | 1963-11-05 | Phenylcyclopropane derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1086192A true GB1086192A (en) | 1967-10-04 |
Family
ID=10429612
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB49345/66A Expired GB1086192A (en) | 1963-11-05 | 1963-11-05 | Phenylcyclopropane derivatives |
| GB43626/63A Expired GB1086191A (en) | 1963-11-05 | 1963-11-05 | Phenylcyclopropane derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB43626/63A Expired GB1086191A (en) | 1963-11-05 | 1963-11-05 | Phenylcyclopropane derivatives |
Country Status (15)
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0015604A1 (en) * | 1979-03-05 | 1980-09-17 | Shell Internationale Researchmaatschappij B.V. | Compounds and compositions for use in inhibition of lipogenesis in mammals |
| US7622589B2 (en) | 2005-03-17 | 2009-11-24 | Pfizer Inc. | Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists |
| US8063215B2 (en) | 2007-08-22 | 2011-11-22 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US8993577B2 (en) | 2009-02-20 | 2015-03-31 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US9012452B2 (en) | 2010-02-18 | 2015-04-21 | Astrazeneca Ab | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4103030A (en) * | 1974-12-11 | 1978-07-25 | Sumitomo Chemical Company, Limited | Novel cyclopropylmethylamine derivatives |
| GB2170197B (en) * | 1985-01-17 | 1988-08-24 | Ici Plc | Tertiary amine compounds |
| DE3582728D1 (de) * | 1985-01-17 | 1991-06-06 | Ici Plc | Tertiaere aminoverbindungen. |
| GB8617377D0 (en) * | 1986-07-16 | 1986-08-20 | Ici Plc | Tertiary amine compounds |
| AU8101191A (en) * | 1990-07-18 | 1992-02-18 | Sandoz Ltd. | 2-cyclopropylacetic acid derivatives |
| WO2007025144A1 (en) * | 2005-08-24 | 2007-03-01 | University Of Illinois - Chicago | 5-ht2c receptor agonists as anorectic agents |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| MX2008016343A (es) | 2006-06-23 | 2009-01-19 | Abbott Lab | Derivados ciclopropil amina como moduladores del receptro de histamina h3. |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3081336A (en) * | 1963-03-12 | Carbamates | ||
| US3050559A (en) * | 1962-08-21 | Substituted phenylcyclopropylamjnes | ||
| US2997422A (en) * | 1959-01-09 | 1961-08-22 | Smith Kline French Lab | Monoamine oxidase inhibition |
| US3106578A (en) * | 1960-09-16 | 1963-10-08 | Smith Kline French Lab | Nu-phenethyl-2-phenylcyclopropylamine derivatives |
| US3079403A (en) * | 1960-09-19 | 1963-02-26 | Smith Kline French Lab | Process for preparing amines |
-
0
- NL NL128365D patent/NL128365C/xx active
-
1963
- 1963-11-05 GB GB49345/66A patent/GB1086192A/en not_active Expired
- 1963-11-05 GB GB43626/63A patent/GB1086191A/en not_active Expired
-
1964
- 1964-10-21 IL IL22302A patent/IL22302A/en unknown
- 1964-11-03 NL NL6412766A patent/NL6412766A/xx unknown
- 1964-11-04 DE DE19641518207 patent/DE1518207B1/de active Pending
- 1964-11-04 BE BE655245D patent/BE655245A/xx unknown
- 1964-11-04 ES ES0305661A patent/ES305661A1/es not_active Expired
- 1964-11-04 CH CH1426464A patent/CH482648A/de not_active IP Right Cessation
- 1964-11-05 AT AT938664A patent/AT269832B/de active
- 1964-11-05 JP JP39062253A patent/JPS4821102B1/ja active Pending
- 1964-11-05 FI FI2317/64A patent/FI43069B/fi active
- 1964-11-05 BR BR164004/64A patent/BR6464004D0/pt unknown
- 1964-11-05 AT AT586167A patent/AT273066B/de active
- 1964-11-05 DK DK546064AA patent/DK127726B/da unknown
- 1964-11-05 LU LU47291D patent/LU47291A1/xx unknown
- 1964-11-05 SE SE13334/64A patent/SE317669B/xx unknown
- 1964-11-05 AT AT586267A patent/AT266812B/de active
-
1965
- 1965-02-04 FR FR4380A patent/FR4555M/fr not_active Expired
- 1965-02-04 FR FR4377A patent/FR4282M/fr not_active Expired
- 1965-02-04 FR FR4379A patent/FR4217M/fr not_active Expired
- 1965-02-04 FR FR4378A patent/FR4554M/fr not_active Expired
-
1967
- 1967-03-02 JP JP42012912A patent/JPS507598B1/ja active Pending
-
1969
- 1969-01-23 NL NL6901128A patent/NL6901128A/xx unknown
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0015604A1 (en) * | 1979-03-05 | 1980-09-17 | Shell Internationale Researchmaatschappij B.V. | Compounds and compositions for use in inhibition of lipogenesis in mammals |
| US7622589B2 (en) | 2005-03-17 | 2009-11-24 | Pfizer Inc. | Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists |
| US7915448B2 (en) * | 2005-03-17 | 2011-03-29 | Pfizer Inc. | Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists |
| US8063215B2 (en) | 2007-08-22 | 2011-11-22 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US9029381B2 (en) | 2007-08-22 | 2015-05-12 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US8993577B2 (en) | 2009-02-20 | 2015-03-31 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US9012452B2 (en) | 2010-02-18 | 2015-04-21 | Astrazeneca Ab | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6901128A (enrdf_load_stackoverflow) | 1969-04-25 |
| JPS4821102B1 (enrdf_load_stackoverflow) | 1973-06-26 |
| JPS507598B1 (enrdf_load_stackoverflow) | 1975-03-27 |
| SE317669B (enrdf_load_stackoverflow) | 1969-11-24 |
| CH482648A (de) | 1969-12-15 |
| FR4217M (enrdf_load_stackoverflow) | 1966-06-13 |
| AT269832B (de) | 1969-04-10 |
| BE655245A (enrdf_load_stackoverflow) | 1965-05-04 |
| BR6464004D0 (pt) | 1973-08-09 |
| ES305661A1 (es) | 1965-05-01 |
| FR4282M (enrdf_load_stackoverflow) | 1966-07-11 |
| FR4554M (enrdf_load_stackoverflow) | 1966-11-02 |
| DK127726B (da) | 1973-12-24 |
| DE1518207B1 (de) | 1971-07-01 |
| NL6412766A (enrdf_load_stackoverflow) | 1965-05-06 |
| IL22302A (en) | 1968-10-24 |
| NL128365C (enrdf_load_stackoverflow) | |
| LU47291A1 (enrdf_load_stackoverflow) | 1965-11-05 |
| FR4555M (enrdf_load_stackoverflow) | 1966-11-02 |
| FI43069B (enrdf_load_stackoverflow) | 1970-10-01 |
| AT266812B (de) | 1968-12-10 |
| GB1086191A (en) | 1967-10-04 |
| AT273066B (de) | 1969-07-25 |
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