GB1085993A - Synthesis and purification of insulins - Google Patents
Synthesis and purification of insulinsInfo
- Publication number
- GB1085993A GB1085993A GB523666A GB523666A GB1085993A GB 1085993 A GB1085993 A GB 1085993A GB 523666 A GB523666 A GB 523666A GB 523666 A GB523666 A GB 523666A GB 1085993 A GB1085993 A GB 1085993A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chain
- insulin
- insulins
- purification
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 102000004877 Insulin Human genes 0.000 title abstract 5
- 108090001061 Insulin Proteins 0.000 title abstract 5
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000004026 insulin derivative Substances 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 8
- 229940125396 insulin Drugs 0.000 abstract 4
- 230000001590 oxidative effect Effects 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF0045168 | 1965-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1085993A true GB1085993A (en) | 1967-10-04 |
Family
ID=7100370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB523666A Expired GB1085993A (en) | 1965-02-06 | 1966-02-07 | Synthesis and purification of insulins |
Country Status (5)
| Country | Link |
|---|---|
| AT (1) | AT264733B (enrdf_load_stackoverflow) |
| BE (1) | BE676069A (enrdf_load_stackoverflow) |
| DK (1) | DK113588B (enrdf_load_stackoverflow) |
| GB (1) | GB1085993A (enrdf_load_stackoverflow) |
| NL (1) | NL6601349A (enrdf_load_stackoverflow) |
-
1966
- 1966-01-21 AT AT55666A patent/AT264733B/de active
- 1966-02-02 NL NL6601349A patent/NL6601349A/xx unknown
- 1966-02-04 BE BE676069D patent/BE676069A/xx unknown
- 1966-02-04 DK DK59366A patent/DK113588B/da unknown
- 1966-02-07 GB GB523666A patent/GB1085993A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL6601349A (enrdf_load_stackoverflow) | 1966-08-08 |
| BE676069A (enrdf_load_stackoverflow) | 1966-08-04 |
| AT264733B (de) | 1968-09-10 |
| DK113588B (da) | 1969-04-08 |
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