GB1085926A - Improvements in or relating to phenothiazine derivatives - Google Patents
Improvements in or relating to phenothiazine derivativesInfo
- Publication number
- GB1085926A GB1085926A GB46413/65A GB4641365A GB1085926A GB 1085926 A GB1085926 A GB 1085926A GB 46413/65 A GB46413/65 A GB 46413/65A GB 4641365 A GB4641365 A GB 4641365A GB 1085926 A GB1085926 A GB 1085926A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- appropriate
- reacting
- cf3so
- ch3so
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Slot Machines And Peripheral Devices (AREA)
Abstract
Compounds of the formula <FORM:1085926/C2/1> where R is OH, OAlkyl, dialkylaminoalkoxy, or NR1R11; R1 and R11 are H, alkyl, dialkylaminoalkyl (where alkyl has 1-3 C atoms) X and X1 are H, CF3, Halogen, NO2, NH2, CH3S-, CF3S-, CH3SO-, CF3SO-, CH3SO2 CF3SO7, 1-5 C-Alkyl or 1-5 C-Alkoxy; X11 is H, CF3, Halogen, CH3.S, CF3S-, CH3SO, CF3SO-, CH3SO2, CF3SO2-, 1-5 C-Alkyl (where X, X1 and X11 are never all H), and Z is S, SO or SO2; the values of X, X1, X11, R and Z being chosen so that when COR is CONH2 in the 1-position and Z is S or SO2, then X, X1 and X11 are not al chlorine and pharmaceutically acceptable acid addition salts are prepared reacting an appropriate phenothiazine with butyl lithium and the adduct with CO2 to give the 1-carboxylic acid, or by reacting an appropriate 2-(21-amino-phenylmercapto)-3-nitrobenzoate with an acid anhydride, then reacting the product with alcoholic alkali metal hydroxide; or by reacting an appropriate 2-amino-thiophenol with an appropriate 2-halo-3-nitrobenzoic acid in the presence of a strong base; or where Z is SO or SO2 by oxidation of the compound where Z is S. Pharmaceutical compositions having anti-inflammatory activity, comprise the compounds of the invention and an inert diluent.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL6514994A NL6514994A (en) | 1964-11-25 | 1965-11-18 | |
| US551562A US3519622A (en) | 1964-11-25 | 1966-05-20 | Phenothiazine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41397464A | 1964-11-25 | 1964-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1085926A true GB1085926A (en) | 1967-10-04 |
Family
ID=23639429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB46413/65A Expired GB1085926A (en) | 1964-11-25 | 1965-11-02 | Improvements in or relating to phenothiazine derivatives |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE672834A (en) |
| BR (1) | BR6575203D0 (en) |
| CH (1) | CH478136A (en) |
| DE (1) | DE1620323A1 (en) |
| ES (1) | ES319884A1 (en) |
| FR (2) | FR4872M (en) |
| GB (1) | GB1085926A (en) |
| SE (1) | SE349042B (en) |
-
1965
- 1965-11-02 GB GB46413/65A patent/GB1085926A/en not_active Expired
- 1965-11-17 DE DE19651620323 patent/DE1620323A1/en active Pending
- 1965-11-22 ES ES0319884A patent/ES319884A1/en not_active Expired
- 1965-11-23 CH CH1608265A patent/CH478136A/en not_active IP Right Cessation
- 1965-11-24 FR FR39536A patent/FR4872M/fr not_active Expired
- 1965-11-24 FR FR39538A patent/FR1476604A/en not_active Expired
- 1965-11-24 SE SE15200/65A patent/SE349042B/xx unknown
- 1965-11-25 BE BE672834D patent/BE672834A/xx unknown
- 1965-11-25 BR BR175203/65A patent/BR6575203D0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES319884A1 (en) | 1966-04-16 |
| BR6575203D0 (en) | 1973-09-06 |
| FR1476604A (en) | 1967-04-14 |
| FR4872M (en) | 1967-02-27 |
| DE1620323A1 (en) | 1970-03-19 |
| CH478136A (en) | 1969-09-15 |
| BE672834A (en) | 1966-05-25 |
| SE349042B (en) | 1972-09-18 |
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