IL41440A - 1-(4-chlorobenzhydryl)-piperazine-4-spiro-1'-morpholinium salts,process for their preparation and pharmaceutical compositions containing them - Google Patents

1-(4-chlorobenzhydryl)-piperazine-4-spiro-1'-morpholinium salts,process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL41440A
IL41440A IL41440A IL4144073A IL41440A IL 41440 A IL41440 A IL 41440A IL 41440 A IL41440 A IL 41440A IL 4144073 A IL4144073 A IL 4144073A IL 41440 A IL41440 A IL 41440A
Authority
IL
Israel
Prior art keywords
composition
compound
formula
active ingredient
reacting
Prior art date
Application number
IL41440A
Other versions
IL41440A0 (en
Original Assignee
Crc Ricerca Chim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crc Ricerca Chim filed Critical Crc Ricerca Chim
Publication of IL41440A0 publication Critical patent/IL41440A0/en
Publication of IL41440A publication Critical patent/IL41440A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1424611 Cytostatic &c medicines CRC COMPAGNIA DI RICERCA CHIMICA SA 1 Feb 1973 [1 Feb 1972] 5076/73 Heading A5B [Also in Division C2] Pharmaceutical preparations showing cytostatic, cancer inhibiting and tranquilizing actions contain (I) (including salts thereof) as active ingredient where X is an anion. Administration is orally, parenterally or by inhalation. [GB1424611A]

Claims (1)

1. - 12 41440/3 Claims 1. A pharmaceutical composition comprising a compound of the formula: or an acid addition salt thereof, in which Y is a halogen atom or a tosyl group * together with a pharmaceutical carrier or diluent, 2. A composition as claimed in Claim 1 in which Y is a group S0.-.R, in which R is a hydrogen atom,alkyl group, phenyl group or substituted phenyl group. 3. A composition as claimed in Claim 1 or Claim 2 in which the compound of formula (I) is prepared by reacting a compound of the formulas CI - 13 - 41440/2 with an excess of a compound of the formula X - CH2, - CHg 0 - dig - CH2 - X ' in which X stands for a halogen atom, and if desired, converting the compound obtained into a compound in which Y stands for another a . wafce* Sinion. Y 4* A composition as claimed in Claim 1 in which X is an iodine atom and the compound of formula I is prepared by reacting the Y corresponding compoiind of formula I in which X is a chlorine or bromine atom with potassium iodi e in an inert solvent. 5. A composition as claimed in Claim 1 or Claim 2 in which the compound of formula I is prepared by reacting a corresponding compound in which X is a hydroxyl group with an appropriate tos lating halogenating or eeftori y-ing agent. 6. A composition as Claimed in Claim 1 or Claim 2 in which the compound of formula (I) is prepared by reacting a compound of the formulas 01 with a halogenatin agent, neutralizing the halogenated product and cyclizing the neutralized halogenated produot in. an inert solven in the resence of an anh drous acid. - 14 - 41440/2 8. A. composition as claimed In any one of the preceding claims in dosage unit form.. 9· A composition as claimed In Claim 8 in which dosage unit contains from 10 to 100 nig of active ingredient. 10. A composition as claimed in Claim 9 in which dosage unit contains from 20 to 80 mg of active Ingredient 1 11. A composition as claimed in Claim 10 in which each active ingredient contains from 25 to 50 mg of active ingredient. 12. A composition as claimed in Claim 1 substantially as hereinbefore described. 15*Compounds of formula (I) as defined in Claim 1. 14·Compounds of formula I as defined in Claim 1 substantially as hereinbefore described. 15·A process for the preparation of compounds as claimed in Claim 33 or Claim 1 as defined in any of Claims 3 to 7. 16.A process for the preparation of compounds of formula I as defined in Claim 1 substantially as hereinbefore described with reference to the Example . For the Applicants Dr. Yitzhak Hess I —-—
IL41440A 1972-02-01 1973-01-31 1-(4-chlorobenzhydryl)-piperazine-4-spiro-1'-morpholinium salts,process for their preparation and pharmaceutical compositions containing them IL41440A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH142072A CH571004A5 (en) 1972-02-01 1972-02-01

Publications (2)

Publication Number Publication Date
IL41440A0 IL41440A0 (en) 1973-03-30
IL41440A true IL41440A (en) 1976-05-31

Family

ID=4210035

Family Applications (1)

Application Number Title Priority Date Filing Date
IL41440A IL41440A (en) 1972-02-01 1973-01-31 1-(4-chlorobenzhydryl)-piperazine-4-spiro-1'-morpholinium salts,process for their preparation and pharmaceutical compositions containing them

Country Status (14)

Country Link
JP (1) JPS5343511B2 (en)
AT (1) AT331250B (en)
BE (1) BE794804A (en)
CA (1) CA994772A (en)
CH (1) CH571004A5 (en)
DE (1) DE2304708A1 (en)
ES (1) ES411147A1 (en)
FR (1) FR2173982B1 (en)
GB (1) GB1424611A (en)
HU (1) HU168740B (en)
IL (1) IL41440A (en)
NL (1) NL7301488A (en)
NO (1) NO138090C (en)
ZA (2) ZA73730B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2341110A1 (en) * 1973-08-14 1975-02-27 Crc Ricerca Chim PROCESS FOR THE PRODUCTION OF PIPERAZINE DERIVATIVES
DE2938557A1 (en) * 1979-09-24 1981-04-23 Isartaler Schraubenkompressoren Gmbh, 8192 Gertsried Motor driven twin screw rotor compressor - is liquid cooled and lubricated by injection into compression chamber
FI75816C (en) * 1981-02-06 1988-08-08 Ucb Sa Process for the preparation of therapeutically active 2- [4- (diphenylmethyl) -1-piperazinyl] -acetic acid or its amide
JPS57134381U (en) * 1981-02-17 1982-08-21

Also Published As

Publication number Publication date
BE794804A (en) 1973-05-16
GB1424611A (en) 1976-02-11
NL7301488A (en) 1973-08-03
ES411147A1 (en) 1975-12-01
ZA744892B (en) 1975-08-27
FR2173982A1 (en) 1973-10-12
ATA69973A (en) 1975-11-15
ZA73730B (en) 1974-04-24
NO138090C (en) 1978-06-28
IL41440A0 (en) 1973-03-30
HU168740B (en) 1976-07-28
AT331250B (en) 1976-08-10
FR2173982B1 (en) 1978-03-24
JPS5343511B2 (en) 1978-11-20
DE2304708A1 (en) 1973-08-23
NO138090B (en) 1978-03-20
JPS4881879A (en) 1973-11-01
CH571004A5 (en) 1975-12-31
CA994772A (en) 1976-08-10

Similar Documents

Publication Publication Date Title
GB1328322A (en) Dihydrobenzonaphthyridinones their preparation and compositions containing them
ES8203883A1 (en) Imidazole derivatives, their preparation and compositions containing them.
GB1106040A (en) Novel benzdiaz[1,4]epine derivatives and a process for the manufacture thereof
US3821394A (en) Antimycotic composition and method employing a substituted benzyl-azoles
IL41440A (en) 1-(4-chlorobenzhydryl)-piperazine-4-spiro-1'-morpholinium salts,process for their preparation and pharmaceutical compositions containing them
GB1253947A (en) Morpholine derivatives, the preparation thereof and compositions containing them
IE39153B1 (en) 2-(phenoxyalkylthio)imidazoles and congeners
IL43063A (en) 2-phenoxy-1-imidazolyl-alkan-3-ones their production and pharmaceutical compositions containing them
IL42384A (en) N-benzhydryl-n'-p-hydroxybenzyl-piperazines and processes for their manufacture and pharmaceutical compositions containing them
US3790594A (en) Thienyl-imidazolyl alkanoic acids
GB1323325A (en) Indolo 1,2-d 1,4 benzodiazepin-6-ones
GB1380145A (en) Acetamidine derivatives process for preparing the same and pharma ceutical uses thereof
GB1445127A (en) Benzocycloheptathiophene derivatives
US3790616A (en) Sulphonic acid esters,their production and compositions of and uses therefor
US3839576A (en) Thienyl-imidazolyl alkanoic acids as antimycotic agents
GB1177841A (en) Novel Bis-Phenoxy-Malonic Acid Derivatives and Process for the Preparation thereof
GB1252487A (en)
GB1431279A (en) Thiazole derivatives and their use as cardiovascular agents
US3446821A (en) Intermediates useful in preparation of butenolides and process therefor
GB1227905A (en)
GB1329447A (en) 4-adamantylaminoalkylamino-2-styryl-quinolines salts and derivatives thereof
GB1158264A (en) Substituted 1,2-Dihydroquinoline-N-Carboxylic Acids and -Thioncarboxylic Acids
GB1230673A (en)
ES239205A1 (en) Cyanacethydrazide derivatives and compositions containing them
US3326937A (en) Butenolides