GB1077603A - A new amine and procss for its manufacture - Google Patents
A new amine and procss for its manufactureInfo
- Publication number
- GB1077603A GB1077603A GB3604265A GB3604265A GB1077603A GB 1077603 A GB1077603 A GB 1077603A GB 3604265 A GB3604265 A GB 3604265A GB 3604265 A GB3604265 A GB 3604265A GB 1077603 A GB1077603 A GB 1077603A
- Authority
- GB
- United Kingdom
- Prior art keywords
- allyloxyphenoxy
- propane
- hydroxy
- isopropylamino
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001412 amines Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- FTJSDHRLVNMSLN-UHFFFAOYSA-N 1-(propan-2-ylamino)-3-(4-prop-2-enoxyphenoxy)propan-2-ol Chemical compound CC(C)NCC(O)COC1=CC=C(OCC=C)C=C1 FTJSDHRLVNMSLN-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
- 239000001294 propane Substances 0.000 abstract 2
- YAPQBXQYLJRXSA-UHFFFAOYSA-N theobromine Chemical compound CN1C(=O)NC(=O)C2=C1N=CN2C YAPQBXQYLJRXSA-UHFFFAOYSA-N 0.000 abstract 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 abstract 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical class O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000006 Nitroglycerin Substances 0.000 abstract 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 abstract 1
- TZRXHJWUDPFEEY-UHFFFAOYSA-N Pentaerythritol Tetranitrate Chemical compound [O-][N+](=O)OCC(CO[N+]([O-])=O)(CO[N+]([O-])=O)CO[N+]([O-])=O TZRXHJWUDPFEEY-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229960005305 adenosine Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229960003711 glyceryl trinitrate Drugs 0.000 abstract 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 abstract 1
- DGMJZELBSFOPHH-KVTDHHQDSA-N mannite hexanitrate Chemical compound [O-][N+](=O)OC[C@@H](O[N+]([O-])=O)[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)CO[N+]([O-])=O DGMJZELBSFOPHH-KVTDHHQDSA-N 0.000 abstract 1
- 229950003934 mannite hexanitrate Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- GQPLMRYTRLFLPF-UHFFFAOYSA-N nitrous oxide Inorganic materials [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960004559 theobromine Drugs 0.000 abstract 1
- 229960000278 theophylline Drugs 0.000 abstract 1
- 229960002485 trolnitrate Drugs 0.000 abstract 1
- HWKQNAWCHQMZHK-UHFFFAOYSA-N trolnitrate Chemical compound [O-][N+](=O)OCCN(CCO[N+]([O-])=O)CCO[N+]([O-])=O HWKQNAWCHQMZHK-UHFFFAOYSA-N 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1180164A CH451915A (de) | 1964-09-10 | 1964-09-10 | Verfahren zur Herstellung eines neuen Amins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1077603A true GB1077603A (en) | 1967-08-02 |
Family
ID=4376996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3604265A Expired GB1077603A (en) | 1964-09-10 | 1965-08-23 | A new amine and procss for its manufacture |
Country Status (14)
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004017964A1 (en) | 2002-08-19 | 2004-03-04 | Pfizer Products Inc. | Combination therapy for hyperproliferative diseases |
| WO2007024945A1 (en) | 2005-08-25 | 2007-03-01 | Novartis Ag | Condensed imidazolo derivatives for the inhibition of aldosterone synthase and aromatase |
| WO2007062314A2 (en) | 2005-11-23 | 2007-05-31 | Bristol-Myers Squibb Company | Heterocyclic cetp inhibitors |
| WO2008070496A2 (en) | 2006-12-01 | 2008-06-12 | Bristol-Myers Squibb Company | N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| EP2392567A1 (en) | 2005-10-21 | 2011-12-07 | Bristol-Myers Squibb Company | Benzothiazine derivatives and their use as lxr modulators |
| WO2014170786A1 (en) | 2013-04-17 | 2014-10-23 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| WO2020150473A2 (en) | 2019-01-18 | 2020-07-23 | Dogma Therapeutics, Inc. | Pcsk9 inhibitors and methods of use thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8305683A1 (es) * | 1981-03-31 | 1983-04-16 | Ciba Geigy Ag | Procedimiento para la obtencion de fenileteres sustituidos. |
| SE457505B (sv) * | 1984-01-10 | 1989-01-09 | Lejus Medical Ab | Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning |
| SE8401907L (sv) * | 1984-04-05 | 1985-10-06 | Haessle Ab | Nya fenoxipropanolaminsalter och farmaceutiska beredningar derav |
| SE453979B (sv) * | 1986-07-04 | 1988-03-21 | Tetra Pak Ab | Forpackningslaminat av pappersskikt och plastskikt forsett med ett genom elektronbestralning herdbart fergskikt, laminatets anvendning till behallare samt av laminatet tillverkad behallare |
-
0
- NL NL130749D patent/NL130749C/xx active
-
1964
- 1964-09-10 CH CH1180164A patent/CH451915A/de unknown
-
1965
- 1965-08-18 IL IL2418765A patent/IL24187A/xx unknown
- 1965-08-19 DE DEC36681A patent/DE1242596B/de active Pending
- 1965-08-23 GB GB3604265A patent/GB1077603A/en not_active Expired
- 1965-09-06 DK DK456465A patent/DK117138B/da unknown
- 1965-09-09 BE BE669402A patent/BE669402A/xx unknown
- 1965-09-09 AT AT1197966A patent/AT266081B/de active
- 1965-09-09 AT AT1196766A patent/AT262977B/de active
- 1965-09-09 NL NL6511785A patent/NL6511785A/xx unknown
- 1965-09-09 AT AT1197066A patent/AT262978B/de active
- 1965-09-09 AT AT825265A patent/AT259544B/de active
- 1965-09-09 FI FI216265A patent/FI45039C/fi active
- 1965-09-09 NO NO15964965A patent/NO115388B/no unknown
- 1965-09-09 SE SE1177865A patent/SE322506B/xx unknown
- 1965-09-10 BR BR17305865A patent/BR6573058D0/pt unknown
- 1965-12-06 FR FR41000A patent/FR4968M/fr not_active Expired
-
1968
- 1968-07-15 CY CY44568A patent/CY445A/xx unknown
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004017964A1 (en) | 2002-08-19 | 2004-03-04 | Pfizer Products Inc. | Combination therapy for hyperproliferative diseases |
| WO2007024945A1 (en) | 2005-08-25 | 2007-03-01 | Novartis Ag | Condensed imidazolo derivatives for the inhibition of aldosterone synthase and aromatase |
| EP2256118A1 (en) | 2005-08-25 | 2010-12-01 | Novartis AG | Condensed imidazolo derivatives for the inhibition of aromatase |
| EP2270011A1 (en) | 2005-08-25 | 2011-01-05 | Novartis AG | Condensed imidazolo derivatives for the inhibition of aromatase |
| EP2392567A1 (en) | 2005-10-21 | 2011-12-07 | Bristol-Myers Squibb Company | Benzothiazine derivatives and their use as lxr modulators |
| WO2007062314A2 (en) | 2005-11-23 | 2007-05-31 | Bristol-Myers Squibb Company | Heterocyclic cetp inhibitors |
| WO2008070496A2 (en) | 2006-12-01 | 2008-06-12 | Bristol-Myers Squibb Company | N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| WO2014170786A1 (en) | 2013-04-17 | 2014-10-23 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| WO2020150473A2 (en) | 2019-01-18 | 2020-07-23 | Dogma Therapeutics, Inc. | Pcsk9 inhibitors and methods of use thereof |
| EP4470609A2 (en) | 2019-01-18 | 2024-12-04 | Astrazeneca AB | Pcsk9 inhibitors and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AT259544B (de) | 1968-01-25 |
| FR4968M (enrdf_load_stackoverflow) | 1967-04-03 |
| SE322506B (enrdf_load_stackoverflow) | 1970-04-13 |
| DK117138B (da) | 1970-03-23 |
| NO115388B (enrdf_load_stackoverflow) | 1968-09-30 |
| FI45039C (fi) | 1972-03-10 |
| BE669402A (enrdf_load_stackoverflow) | 1966-03-09 |
| CH451915A (de) | 1968-05-15 |
| NL6511785A (enrdf_load_stackoverflow) | 1966-03-11 |
| DE1242596B (de) | 1967-06-22 |
| CY445A (en) | 1968-07-15 |
| AT266081B (de) | 1968-11-11 |
| AT262978B (de) | 1968-07-10 |
| AT262977B (de) | 1968-07-10 |
| BR6573058D0 (pt) | 1973-08-28 |
| IL24187A (en) | 1969-04-30 |
| NL130749C (enrdf_load_stackoverflow) | |
| FI45039B (enrdf_load_stackoverflow) | 1971-11-30 |
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