GB1077603A - A new amine and procss for its manufacture - Google Patents

A new amine and procss for its manufacture

Info

Publication number
GB1077603A
GB1077603A GB3604265A GB3604265A GB1077603A GB 1077603 A GB1077603 A GB 1077603A GB 3604265 A GB3604265 A GB 3604265A GB 3604265 A GB3604265 A GB 3604265A GB 1077603 A GB1077603 A GB 1077603A
Authority
GB
United Kingdom
Prior art keywords
allyloxyphenoxy
propane
hydroxy
isopropylamino
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3604265A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4376996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1077603(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB1077603A publication Critical patent/GB1077603A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Abstract

1 - Isopropylamino - 2- hydroxy - 3 - (o-allyloxyphenoxy) propane and its acid addition salts are prepared by reacting a 1-halo-2-hydroxy-3-(o-allyloxyphenoxy) propane or 3-(o-allyloxyphenoxy)-1, 2-epoxypropane (I) with isopropylamine, optionally followed by salt formation and/or resolution. The preparation of (I) and 1-chloro-2-hydroxy-3-(o-allyloxyphenoxy) propane is described.ALSO:Pharmaceutical compositions for the treatment of cardiac and circulatory diseases comprise racemic or optically active 1-isopropylamino- 2 -hydroxy- 3 -(o-allyloxyphenoxy)-propane or an acid addition salt thereof together with a carrier. The compositions may also contain other active ingredients, such as vasodilators including nitrous and nitric acid esters such as nitroglycerin, nitromannitol, P.E.T.N., triethanolamine trinitrate; paparexine; theobromine, theophylline and their derivatives; 2-ethyl- 3 -(3\sv5\sv-diiodo-4\sv-hydroxybenzoyl)-benzofuran; 2,6-bis-diethanolamino -4,8-di-piperidino pyrimido-(5,4-d)-pyrimidine; N-3\sv-phenyl-propyl-(2\sv)-1, 1-diphenylpropyl-(3)-amine and adenosine.
GB3604265A 1964-09-10 1965-08-23 A new amine and procss for its manufacture Expired GB1077603A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1180164A CH451915A (en) 1964-09-10 1964-09-10 Process for the preparation of a new amine

Publications (1)

Publication Number Publication Date
GB1077603A true GB1077603A (en) 1967-08-02

Family

ID=4376996

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3604265A Expired GB1077603A (en) 1964-09-10 1965-08-23 A new amine and procss for its manufacture

Country Status (14)

Country Link
AT (4) AT262978B (en)
BE (1) BE669402A (en)
BR (1) BR6573058D0 (en)
CH (1) CH451915A (en)
CY (1) CY445A (en)
DE (1) DE1242596B (en)
DK (1) DK117138B (en)
FI (1) FI45039C (en)
FR (1) FR4968M (en)
GB (1) GB1077603A (en)
IL (1) IL24187A (en)
NL (2) NL6511785A (en)
NO (1) NO115388B (en)
SE (1) SE322506B (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
WO2007024945A1 (en) 2005-08-25 2007-03-01 Novartis Ag Condensed imidazolo derivatives for the inhibition of aldosterone synthase and aromatase
WO2007062314A2 (en) 2005-11-23 2007-05-31 Bristol-Myers Squibb Company Heterocyclic cetp inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
EP2392567A1 (en) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Benzothiazine derivatives and their use as lxr modulators
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE457505B (en) * 1984-01-10 1989-01-09 Lejus Medical Ab LAMINATED ORAL PHARMACEUTICAL COMPOSITION AND PROCEDURES FOR ITS PREPARATION
SE8401907L (en) * 1984-04-05 1985-10-06 Haessle Ab NEW PHENOXIPROPANOLAMINE SALTS AND PHARMACEUTICAL PREPARATIONS THEREOF
SE453979B (en) * 1986-07-04 1988-03-21 Tetra Pak Ab PACKAGING LAMINATE OF PAPER LAYER AND PLASTIC LAYER PROVIDED WITH AN ELECTRONIC RADIATION HARDENABLE FRESH LAYER, USE OF THE LAMINATE TO CONTAINER AND OF THE LAMINATE MANUFACTURED CONTAINER

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
WO2007024945A1 (en) 2005-08-25 2007-03-01 Novartis Ag Condensed imidazolo derivatives for the inhibition of aldosterone synthase and aromatase
EP2256118A1 (en) 2005-08-25 2010-12-01 Novartis AG Condensed imidazolo derivatives for the inhibition of aromatase
EP2270011A1 (en) 2005-08-25 2011-01-05 Novartis AG Condensed imidazolo derivatives for the inhibition of aromatase
EP2392567A1 (en) 2005-10-21 2011-12-07 Bristol-Myers Squibb Company Benzothiazine derivatives and their use as lxr modulators
WO2007062314A2 (en) 2005-11-23 2007-05-31 Bristol-Myers Squibb Company Heterocyclic cetp inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2020150473A2 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof

Also Published As

Publication number Publication date
CH451915A (en) 1968-05-15
AT262978B (en) 1968-07-10
FR4968M (en) 1967-04-03
NL6511785A (en) 1966-03-11
DE1242596B (en) 1967-06-22
BR6573058D0 (en) 1973-08-28
NL130749C (en)
CY445A (en) 1968-07-15
IL24187A (en) 1969-04-30
BE669402A (en) 1966-03-09
SE322506B (en) 1970-04-13
FI45039B (en) 1971-11-30
AT266081B (en) 1968-11-11
DK117138B (en) 1970-03-23
AT259544B (en) 1968-01-25
FI45039C (en) 1972-03-10
AT262977B (en) 1968-07-10
NO115388B (en) 1968-09-30

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