GB1075420A - Cyclic imide compounds and a process for their production - Google Patents
Cyclic imide compounds and a process for their productionInfo
- Publication number
- GB1075420A GB1075420A GB20487/66A GB2048766A GB1075420A GB 1075420 A GB1075420 A GB 1075420A GB 20487/66 A GB20487/66 A GB 20487/66A GB 2048766 A GB2048766 A GB 2048766A GB 1075420 A GB1075420 A GB 1075420A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- r1r2n
- substituted
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Cyclic imide compounds Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 125000004122 cyclic group Chemical group 0.000 abstract 3
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 239000004202 carbamide Substances 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- VSNMIAXOGBPRIQ-UHFFFAOYSA-N 2-(2,5-dioxopyrrolidin-3-yl)isoindole-1,3-dione Chemical compound O=C1NC(=O)CC1N1C(=O)C2=CC=CC=C2C1=O VSNMIAXOGBPRIQ-UHFFFAOYSA-N 0.000 abstract 1
- ZYHBIWLWOMNLKL-UHFFFAOYSA-N 2-[1-(hydroxymethyl)-2,5-dioxopyrrolidin-3-yl]isoindole-1,3-dione Chemical compound OCN1C(=O)CC(N2C(=O)C3=CC=CC=C3C2=O)C1=O ZYHBIWLWOMNLKL-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 230000002124 endocrine Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 150000003949 imides Chemical class 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Connector Housings Or Holding Contact Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC0035799 | 1965-05-08 | ||
| DEC0037133 | 1965-10-12 | ||
| DEC0037142 | 1965-10-13 | ||
| AT934165A AT260240B (de) | 1965-10-15 | 1965-10-15 | Verfahren zur Herstellung von neuen Dikarbonsäureimidderivaten, sowie Salzen dieser Verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1075420A true GB1075420A (en) | 1967-07-12 |
Family
ID=27422273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB20487/66A Expired GB1075420A (en) | 1965-05-08 | 1966-05-09 | Cyclic imide compounds and a process for their production |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE680696A (enrdf_load_stackoverflow) |
| CH (1) | CH478117A (enrdf_load_stackoverflow) |
| FR (2) | FR1592059A (enrdf_load_stackoverflow) |
| GB (1) | GB1075420A (enrdf_load_stackoverflow) |
| IL (1) | IL25595A (enrdf_load_stackoverflow) |
| NO (1) | NO123088B (enrdf_load_stackoverflow) |
| OA (1) | OA01951A (enrdf_load_stackoverflow) |
| PH (1) | PH10158A (enrdf_load_stackoverflow) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2081463A1 (en) * | 1970-01-28 | 1971-12-03 | Gruenenthal Chemie | O-sulphobenzoic acid mido glutarimide derivs - sedatives and immunosuppressants |
| US4374220A (en) | 1968-09-18 | 1983-02-15 | Raychem Corporation | Imide flame retardants and compositions containing them |
| US4535170A (en) * | 1968-09-18 | 1985-08-13 | Raychem Corporation | Flame retardants and compositions containing them |
| US4581396A (en) * | 1968-09-18 | 1986-04-08 | Raychem Corporation | Flame retardants and compositions containing them |
| US4644066A (en) * | 1968-09-18 | 1987-02-17 | Raychem Corporation | Flame retardants and compositions containing them |
| WO1999047512A1 (en) * | 1998-03-16 | 1999-09-23 | Colgene Corporation | 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines |
| WO2002070480A1 (es) * | 2001-03-01 | 2002-09-12 | Fundacion Universitaria San Pablo Ceu | Derivados de glutarimida como agentes terapeuticos |
| WO2005016326A3 (en) * | 2003-07-11 | 2005-06-16 | Us Gov Health & Human Serv | Analogs of thalidomide as potential angiogenesis inhibitors |
| US7320991B2 (en) | 2001-02-27 | 2008-01-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Analogs of thalidomide as potential angiogenesis inhibitors |
| US7973057B2 (en) | 2003-09-17 | 2011-07-05 | The United States Of America As Represented By The Department Of Health And Human Services | Thalidomide analogs |
| US8143252B2 (en) | 2006-04-13 | 2012-03-27 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Tetrahalogenated compounds useful as inhibitors of angiogenesis |
| US8853253B2 (en) | 2003-09-17 | 2014-10-07 | P2D, Inc. | Thalidomide analogs |
| US9084783B2 (en) | 2011-12-02 | 2015-07-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
-
1966
- 1966-04-15 IL IL25595A patent/IL25595A/en unknown
- 1966-04-27 OA OA52430A patent/OA01951A/xx unknown
- 1966-05-06 FR FR60670A patent/FR1592059A/fr not_active Expired
- 1966-05-06 CH CH659466A patent/CH478117A/de not_active IP Right Cessation
- 1966-05-06 BE BE680696A patent/BE680696A/xx unknown
- 1966-05-07 NO NO162918A patent/NO123088B/no unknown
- 1966-05-09 PH PH7308A patent/PH10158A/en unknown
- 1966-05-09 GB GB20487/66A patent/GB1075420A/en not_active Expired
- 1966-08-05 FR FR72315A patent/FR5806M/fr not_active Expired
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4374220A (en) | 1968-09-18 | 1983-02-15 | Raychem Corporation | Imide flame retardants and compositions containing them |
| US4535170A (en) * | 1968-09-18 | 1985-08-13 | Raychem Corporation | Flame retardants and compositions containing them |
| US4581396A (en) * | 1968-09-18 | 1986-04-08 | Raychem Corporation | Flame retardants and compositions containing them |
| US4644066A (en) * | 1968-09-18 | 1987-02-17 | Raychem Corporation | Flame retardants and compositions containing them |
| FR2081463A1 (en) * | 1970-01-28 | 1971-12-03 | Gruenenthal Chemie | O-sulphobenzoic acid mido glutarimide derivs - sedatives and immunosuppressants |
| EP1357120A1 (en) * | 1998-03-16 | 2003-10-29 | Celgene Corporation | 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines |
| JP2011042674A (ja) * | 1998-03-16 | 2011-03-03 | Celgene Corp | ２−（２，６−ジオキソピペリジン−３−イル）イソインドリン誘導体、その製剤および炎症性サイトカイン阻害剤としてのその使用 |
| JP2002506861A (ja) * | 1998-03-16 | 2002-03-05 | コルジーン コーポレイション | ２−（２，６−ジオキソピペリジン−３−イル）イソインドリン誘導体、その製剤および炎症性サイトカイン阻害剤としてのその使用 |
| CZ299253B6 (cs) * | 1998-03-16 | 2008-05-28 | Celgene Corporation | Isoindolinový derivát, jeho použití pro výrobu léciva a farmaceutická kompozice tento derivát obsahující |
| RU2200159C2 (ru) * | 1998-03-16 | 2003-03-10 | Селджин Корпорейшн | Производные 2-(2,6-диоксопиперидин-3-ил)изоиндолина, их получение и их применение в качестве ингибиторов воспалительных цитокинов |
| WO1999047512A1 (en) * | 1998-03-16 | 1999-09-23 | Colgene Corporation | 2-(2,6-dioxopiperidin-3-yl)isoindoline derivatives, their preparation and their use as inhibitors of inflammatory cytokines |
| US7320991B2 (en) | 2001-02-27 | 2008-01-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Analogs of thalidomide as potential angiogenesis inhibitors |
| US8716315B2 (en) | 2001-02-27 | 2014-05-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Analogs of thalidomide as potential angiogenesis inhibitors |
| ES2172474A1 (es) * | 2001-03-01 | 2002-09-16 | Fundacion Universitaria San Pa | Derivados de glutarimida como agentes terapeuticos. |
| WO2002070480A1 (es) * | 2001-03-01 | 2002-09-12 | Fundacion Universitaria San Pablo Ceu | Derivados de glutarimida como agentes terapeuticos |
| WO2005016326A3 (en) * | 2003-07-11 | 2005-06-16 | Us Gov Health & Human Serv | Analogs of thalidomide as potential angiogenesis inhibitors |
| US7973057B2 (en) | 2003-09-17 | 2011-07-05 | The United States Of America As Represented By The Department Of Health And Human Services | Thalidomide analogs |
| US8546430B2 (en) | 2003-09-17 | 2013-10-01 | P2D, Inc. | Thalidomide analogs |
| US8853253B2 (en) | 2003-09-17 | 2014-10-07 | P2D, Inc. | Thalidomide analogs |
| US8143252B2 (en) | 2006-04-13 | 2012-03-27 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Tetrahalogenated compounds useful as inhibitors of angiogenesis |
| US9084783B2 (en) | 2011-12-02 | 2015-07-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
| US9623020B2 (en) | 2011-12-02 | 2017-04-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
| US10220028B2 (en) | 2011-12-02 | 2019-03-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| IL25595A (en) | 1971-01-28 |
| BE680696A (enrdf_load_stackoverflow) | 1966-11-07 |
| PH10158A (en) | 1976-09-13 |
| NO123088B (enrdf_load_stackoverflow) | 1971-09-27 |
| OA01951A (fr) | 1970-02-04 |
| FR1592059A (enrdf_load_stackoverflow) | 1970-05-11 |
| CH478117A (de) | 1969-09-15 |
| FR5806M (enrdf_load_stackoverflow) | 1968-02-19 |
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