GB1057194A - A new antibiotic, tuoromycin, and its manufacture - Google Patents
A new antibiotic, tuoromycin, and its manufactureInfo
- Publication number
- GB1057194A GB1057194A GB17616/64A GB1761664A GB1057194A GB 1057194 A GB1057194 A GB 1057194A GB 17616/64 A GB17616/64 A GB 17616/64A GB 1761664 A GB1761664 A GB 1761664A GB 1057194 A GB1057194 A GB 1057194A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tuoromycin
- chloroform
- acetone
- water
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
<PICT:1057194/C2/1> The invention relates to an anti-tumour antibiotic tuoromycin which is effective against gram positive microorganisms, is weakly acidic forming violet crystals of melting point 216-220 DEG C.; is insoluble in water, dilute mineral acid, diethyl ether and hexane; sparingly soluble in methanol, ethanol, n-butanol, carbon tetrachloride and dilute aqueous Na2CO3; moderately soluble in acetone, ethyl acetate, propylene glycol, polyethylene glycol and ethylene glycol mono-methyl ether; readily soluble in benzene, dioxane, methylene chloride, chloroform, dimethylsulphoxide and dilute aqueous alkali with which it forms salts; gives in elementary analysis C=57.17%, H=3.63%, O=39.20%; shows U.V. maximum <FORM:1057194/C2/1> <FORM:1057194/C2/2> <FORM:1057194/C2/3> shows Rf value 0.7 in paper chromatogram system benzene and chloroform (2:1), paper impregnated with 20% formamide in acetone; Rf 0.85 silica gel chromatogram in system chloroform and methanol (8:2) and Rf value 0.75 in system ethyl acetate and methyl ethyl ketone and formic acid and water (50:30:10:10). Tuoromycin is produced by cultivating Streptomyces tuirus N.R.R.L. 3120 under aerobic conditions in an aqueous nutrient medium containing a source of C, N and inorganic salts. A typical medium contains soybean flour-(C and N source), CaCO3 and NaCl in water. The antibiotic may be isolated from the separated mycelium by extraction with acetone followed by removal of the solvent or precipitation with a non-solvent, e.g. petroleum ether. Purification may be by recrystallization from solvents, chromatography or countercurrent distribution. Tuoromycin or a salt thereof may be formulated into compositions for human or animal use. Typical formulations are tablets, dragees, powders, suppositories, suspensions and injections. It may be used as a disinfectant, preserving agent or additive for animal feedstuffs.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH535163 | 1963-04-29 | ||
| BE647217A BE647217A (en) | 1963-04-29 | 1964-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1057194A true GB1057194A (en) | 1967-02-01 |
Family
ID=25655867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17616/64A Expired GB1057194A (en) | 1963-04-29 | 1964-04-28 | A new antibiotic, tuoromycin, and its manufacture |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE647217A (en) |
| BR (1) | BR6458746D0 (en) |
| DE (1) | DE1209701B (en) |
| FR (1) | FR3676M (en) |
| GB (1) | GB1057194A (en) |
| NL (1) | NL6404698A (en) |
-
1964
- 1964-04-28 BE BE647217A patent/BE647217A/xx unknown
- 1964-04-28 BR BR158746/64A patent/BR6458746D0/en unknown
- 1964-04-28 NL NL6404698A patent/NL6404698A/xx unknown
- 1964-04-28 DE DEC32745A patent/DE1209701B/en active Pending
- 1964-04-28 GB GB17616/64A patent/GB1057194A/en not_active Expired
- 1964-07-24 FR FR982887A patent/FR3676M/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BR6458746D0 (en) | 1973-09-11 |
| DE1209701B (en) | 1966-01-27 |
| BE647217A (en) | 1964-10-28 |
| FR3676M (en) | 1965-11-08 |
| NL6404698A (en) | 1964-10-30 |
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