GB1048555A - 6-methyl- and 1,6-dimethyl-ergoline i derivatives - Google Patents

6-methyl- and 1,6-dimethyl-ergoline i derivatives

Info

Publication number
GB1048555A
GB1048555A GB28935/63A GB2893563A GB1048555A GB 1048555 A GB1048555 A GB 1048555A GB 28935/63 A GB28935/63 A GB 28935/63A GB 2893563 A GB2893563 A GB 2893563A GB 1048555 A GB1048555 A GB 1048555A
Authority
GB
United Kingdom
Prior art keywords
ergoline
hydroxymethyl
general formula
hydrogen atom
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28935/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of GB1048555A publication Critical patent/GB1048555A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine

Abstract

The invention c omprises ergoline I derivatives of the general formula <F\1> wherein, when R is a hydrogen atom, R1 is an acyl radical of an alkanoic or carbomoic carboxylic acid having from 3-10 carbon atoms or an unsubstituted aromatic or a pyridine carboxylic acid, and, when R is a methyl group, R1 is a hydrogen atom or an acyl radical as just defined, and the preparation thereof by esterification of the corresponding 8-hydroxymethy-ergoline I derivative with the appropriate acid halide or anhydride; the 1,6dimethyl -8-hydroxymethyl-ergoline I being prepared by reaction in liquid ammonia of methyl iodide with the potassium salt of the 6-methyl8-hydroxymethyl-ergoline I which is itself prepared by reduction with lithium aluminium hydride of an ester of dihydrolysergic acid. Therapeutic compositions for oral or parenteral administration, having oxytocic, antienteraminic, andrenolytic, hypotensive and sedative activity, comprise a compound of the above general formula and an excipient or diluent. Reference has been directed by the Comptroller to Specification 1,008,466.
GB28935/63A 1962-07-26 1963-07-22 6-methyl- and 1,6-dimethyl-ergoline i derivatives Expired GB1048555A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1506562 1962-07-26

Publications (1)

Publication Number Publication Date
GB1048555A true GB1048555A (en) 1966-11-16

Family

ID=11146222

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28935/63A Expired GB1048555A (en) 1962-07-26 1963-07-22 6-methyl- and 1,6-dimethyl-ergoline i derivatives

Country Status (7)

Country Link
AT (1) AT243993B (en)
BE (1) BE635411A (en)
CH (1) CH454890A (en)
DE (1) DE1470248A1 (en)
DK (1) DK104939C (en)
ES (1) ES290275A2 (en)
GB (1) GB1048555A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4417051A (en) * 1980-01-16 1983-11-22 Schering, Aktiengesellschaft Process for the preparation of 8α-substituted 6-methylergolines

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1094965B (en) * 1978-04-05 1985-08-10 Corvi Mora E LISERGOL DERIVATION PREPARATION PROCEDURE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4417051A (en) * 1980-01-16 1983-11-22 Schering, Aktiengesellschaft Process for the preparation of 8α-substituted 6-methylergolines

Also Published As

Publication number Publication date
DE1470248A1 (en) 1969-10-09
AT243993B (en) 1965-12-10
ES290275A2 (en) 1964-03-01
CH454890A (en) 1968-04-30
BE635411A (en) 1963-11-18
DK104939C (en) 1966-07-25

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