GB1040900A - Novel pyridine derivatives and a process for the manufacture thereof - Google Patents

Novel pyridine derivatives and a process for the manufacture thereof

Info

Publication number
GB1040900A
GB1040900A GB33997/65A GB3399765A GB1040900A GB 1040900 A GB1040900 A GB 1040900A GB 33997/65 A GB33997/65 A GB 33997/65A GB 3399765 A GB3399765 A GB 3399765A GB 1040900 A GB1040900 A GB 1040900A
Authority
GB
United Kingdom
Prior art keywords
group
acid addition
pyridine derivatives
novel pyridine
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33997/65A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1040900A publication Critical patent/GB1040900A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention comprises novel pyridine derivatives of general formulaeae <FORM:1040900/C2/1> wherein A represents a carbonyl group and R represents a phenyl group which is substituted by a fluorine atom or a lower alkoxy group or represents a C3-C8 cycloalkyl or 5- or 6-membered heteromonocyclic group in which the heteroatoms are nitrogen, oxygen and/or sulphur, and acid addition salts thereof prepared by reacting a [pyridyl-(4)-methyl]-(alkali metal) derivative with a carbonyl compound of formula <FORM:1040900/C2/2> wherein R has the significance above and R1 stands for a halogen atom or a lower-alkoxy, phenoxy or benzyloxy group, and if desired converting the reaction product into an acid addition salt. Pharmaceutical compositions having anticonvulsant and hypothermia reducing activity can be administered enterally or parenterally in the form of tablets, dragees, suppositories, capsules, or in liquid form as solutions, suspensions, or emulsions, contain a compound of the first general formula above as the active ingredient.
GB33997/65A 1964-08-26 1965-08-09 Novel pyridine derivatives and a process for the manufacture thereof Expired GB1040900A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39227664A 1964-08-26 1964-08-26

Publications (1)

Publication Number Publication Date
GB1040900A true GB1040900A (en) 1966-09-01

Family

ID=23549974

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33997/65A Expired GB1040900A (en) 1964-08-26 1965-08-09 Novel pyridine derivatives and a process for the manufacture thereof

Country Status (7)

Country Link
BE (1) BE668701A (en)
BR (1) BR6572205D0 (en)
DE (1) DE1545958A1 (en)
ES (1) ES316801A1 (en)
FR (2) FR5116M (en)
GB (1) GB1040900A (en)
NL (1) NL6511025A (en)

Also Published As

Publication number Publication date
DE1545958A1 (en) 1969-11-20
BR6572205D0 (en) 1973-08-16
FR1455325A (en) 1966-04-01
BE668701A (en) 1966-02-24
ES316801A1 (en) 1966-04-16
FR5116M (en) 1967-05-29
NL6511025A (en) 1966-02-28

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