GB1142143A - Piperidine-butyrophenones and a process for their production - Google Patents

Piperidine-butyrophenones and a process for their production

Info

Publication number
GB1142143A
GB1142143A GB12449/65A GB1244965A GB1142143A GB 1142143 A GB1142143 A GB 1142143A GB 12449/65 A GB12449/65 A GB 12449/65A GB 1244965 A GB1244965 A GB 1244965A GB 1142143 A GB1142143 A GB 1142143A
Authority
GB
United Kingdom
Prior art keywords
piperidine derivatives
butyrophenones
halogeno
march
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB12449/65A
Inventor
Sven Erik Harry Hernestam
Nils Olov Bruno Sterner
Jorgen Buus Lassen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia Animal Health Inc
Original Assignee
Ferrosan AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan AB filed Critical Ferrosan AB
Priority to GB12449/65A priority Critical patent/GB1142143A/en
Priority to SE03507/66A priority patent/SE332984B/xx
Priority to NO162139A priority patent/NO122526B/no
Priority to CH393566A priority patent/CH492705A/en
Priority to FI660714A priority patent/FI47764C/en
Priority to DE1645901A priority patent/DE1645901C3/en
Priority to ES0324502A priority patent/ES324502A1/en
Priority to FR54694A priority patent/FR5474M/fr
Priority to LU50735A priority patent/LU50735A1/xx
Priority to NL6603799A priority patent/NL6603799A/xx
Priority to FR54696A priority patent/FR1497477A/en
Priority to DK151366AA priority patent/DK117829B/en
Priority to BE678362D priority patent/BE678362A/xx
Priority to BE683543D priority patent/BE683543A/xx
Publication of GB1142143A publication Critical patent/GB1142143A/en
Priority to US00078289A priority patent/US3816433A/en
Priority claimed from US00078289A external-priority patent/US3816433A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Supports Or Holders For Household Use (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,142,143. Piperidine derivatives. A. B. FERROSAN. 21 March, 1966 [24 March, 1965], No. 12449/65. Heading C2C. Novel piperidine derivatives of the formula wherein R 1 represents a C 2-5 straight or branched alkyl group and R 2 represents a hydrogen or a fluorine atom, and their acid addition salts are obtained by reacting 4-alkyl piperidines with #-halogeno-butyrophenones or #-halogeno-#- fluoro-butyro-phenones at an elevated temperature and in the presence of an acid binding agent and, if desired, reacting the products with acids. Therapeutic compositions, useful as local anaesthetics, anticonvulsants, psycho-sedatives, analgetics or antidepressives, contain as active ingredient the above piperidine derivatives. The composition may be in a form suitable for oral application.
GB12449/65A 1965-03-24 1965-03-24 Piperidine-butyrophenones and a process for their production Expired GB1142143A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GB12449/65A GB1142143A (en) 1965-03-24 1965-03-24 Piperidine-butyrophenones and a process for their production
SE03507/66A SE332984B (en) 1965-03-24 1966-03-16
NO162139A NO122526B (en) 1965-03-24 1966-03-16
CH393566A CH492705A (en) 1965-03-24 1966-03-18 Process for the production of pharmacologically active ketones
FI660714A FI47764C (en) 1965-03-24 1966-03-21 Process for the preparation of - (4-alkylpiperidino) -p-F-butyrophenones having pharmacologically valuable properties.
DE1645901A DE1645901C3 (en) 1965-03-24 1966-03-22 gamma- (4-alkylp! peridino) -p-fluorobutyrophenones and process for their preparation
ES0324502A ES324502A1 (en) 1965-03-24 1966-03-22 Procedure for the preparation of basic butirophenones. (Machine-translation by Google Translate, not legally binding)
FR54694A FR5474M (en) 1965-03-24 1966-03-23
LU50735A LU50735A1 (en) 1965-03-24 1966-03-23
NL6603799A NL6603799A (en) 1965-03-24 1966-03-23
FR54696A FR1497477A (en) 1965-03-24 1966-03-23 Process for the preparation of basic ketones
DK151366AA DK117829B (en) 1965-03-24 1966-03-23 Process for the preparation of basic ketones or acid addition salts thereof.
BE678362D BE678362A (en) 1965-03-24 1966-03-24
BE683543D BE683543A (en) 1965-03-24 1966-07-01
US00078289A US3816433A (en) 1965-03-24 1970-10-05 4-fluoro-ypsilon-(4-methylpiperidino)-butyrophenone and its pharmaceutically acceptable salts

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB12449/65A GB1142143A (en) 1965-03-24 1965-03-24 Piperidine-butyrophenones and a process for their production
US00078289A US3816433A (en) 1965-03-24 1970-10-05 4-fluoro-ypsilon-(4-methylpiperidino)-butyrophenone and its pharmaceutically acceptable salts

Publications (1)

Publication Number Publication Date
GB1142143A true GB1142143A (en) 1969-02-05

Family

ID=26249030

Family Applications (1)

Application Number Title Priority Date Filing Date
GB12449/65A Expired GB1142143A (en) 1965-03-24 1965-03-24 Piperidine-butyrophenones and a process for their production

Country Status (11)

Country Link
BE (2) BE678362A (en)
CH (1) CH492705A (en)
DE (1) DE1645901C3 (en)
DK (1) DK117829B (en)
FI (1) FI47764C (en)
FR (2) FR5474M (en)
GB (1) GB1142143A (en)
LU (1) LU50735A1 (en)
NL (1) NL6603799A (en)
NO (1) NO122526B (en)
SE (1) SE332984B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344952A (en) 1980-05-30 1982-08-17 Ab Ferrosan Method of treating diarrhoea with gamma-piperidino-butyrophenones
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4344952A (en) 1980-05-30 1982-08-17 Ab Ferrosan Method of treating diarrhoea with gamma-piperidino-butyrophenones
EP0041493B1 (en) * 1980-05-30 1987-03-04 AB Ferrosan Use of gamma-piperidino-butyrophenones for the preparation of medicaments for treating diarrhoea
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
US7485651B2 (en) 1998-03-31 2009-02-03 Acadia Pharmaceuticals, Inc. Compounds with activity on muscarinic receptors

Also Published As

Publication number Publication date
LU50735A1 (en) 1966-05-23
SE332984B (en) 1971-03-01
DE1645901B2 (en) 1974-06-12
FR1497477A (en) 1967-10-13
DE1645901C3 (en) 1975-01-30
BE678362A (en) 1966-09-01
DK117829B (en) 1970-06-08
CH492705A (en) 1970-06-30
FI47764C (en) 1974-03-11
FI47764B (en) 1973-11-30
BE683543A (en) 1966-12-16
DE1645901A1 (en) 1970-07-16
NO122526B (en) 1971-07-12
NL6603799A (en) 1966-09-26
FR5474M (en) 1967-10-23

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