GB1033383A - New tetrahydro-pyrido-[4,3-d]-pyrimidines - Google Patents
New tetrahydro-pyrido-[4,3-d]-pyrimidinesInfo
- Publication number
- GB1033383A GB1033383A GB10640/63A GB1064063A GB1033383A GB 1033383 A GB1033383 A GB 1033383A GB 10640/63 A GB10640/63 A GB 10640/63A GB 1064063 A GB1064063 A GB 1064063A GB 1033383 A GB1033383 A GB 1033383A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- group
- alkyl
- aralkylthio
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AESJTDNODAZMEA-UHFFFAOYSA-N 1,2,3,4-tetrahydropyrido[4,3-d]pyrimidine Chemical class N1=CC=C2NCNCC2=C1 AESJTDNODAZMEA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- -1 di-substituted amino group Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- STXKJIIHKFGUCY-UHFFFAOYSA-N 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine Chemical class C1=NC=C2CNCCC2=N1 STXKJIIHKFGUCY-UHFFFAOYSA-N 0.000 abstract 1
- 238000006228 Dieckmann condensation reaction Methods 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000003385 bacteriostatic effect Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 230000000916 dilatatory effect Effects 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET21812A DE1285478B (de) | 1962-03-22 | 1962-03-22 | Verfahren zur Herstellung von neuen 5, 6, 7, 8-Tetrahydropyrido-[4, 3-d]pyrimidinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1033383A true GB1033383A (en) | 1966-06-22 |
Family
ID=7550279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB10640/63A Expired GB1033383A (en) | 1962-03-22 | 1963-03-18 | New tetrahydro-pyrido-[4,3-d]-pyrimidines |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US3306901A (enExample) |
| CA (1) | CA764962A (enExample) |
| CH (1) | CH435305A (enExample) |
| DE (1) | DE1285478B (enExample) |
| FR (1) | FR2928M (enExample) |
| GB (1) | GB1033383A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001044246A1 (en) * | 1999-12-17 | 2001-06-21 | Chiron Corporation | Bicyclic inhibitors of glycogen synthase kinase 3 |
| EP1607396A1 (en) * | 1999-12-17 | 2005-12-21 | Chiron Corporation | Bicyclic inhibitors of glycogen synthase kinase 3 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3444168A (en) * | 1966-12-30 | 1969-05-13 | Sterling Drug Inc | 6 - (lower-alkanoyl) - 4 - hydroxy - 2 - mercapto - 5,6,7,8 - tetrahydropyrido(4,3 - d)pyrimidines |
| US3725405A (en) * | 1970-06-18 | 1973-04-03 | American Home Prod | 2,4,7-TRISUBSTITUTED-{8 PYRIDO 2,3-d{9 PYRIMIDINE-6-CARBOXAMIDES |
| DE3729657A1 (de) * | 1987-09-04 | 1989-03-23 | Hoechst Ag | Harzsaeureester auf basis von novolakoxalkylaten, ihre herstellung und verwendung |
| DE3822043A1 (de) * | 1988-06-30 | 1990-01-11 | Hoechst Ag | Grenzflaechenaktive verbindungen auf basis von oxynaphthoesaeureestern, ihre herstellung und verwendung |
| US5212310A (en) * | 1991-12-19 | 1993-05-18 | Neurogen Corporation | Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands |
| PA8539401A1 (es) * | 2001-02-14 | 2002-10-28 | Warner Lambert Co | Quinazolinas como inhibidores de mmp-13 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2697710A (en) * | 1953-01-02 | 1954-12-21 | Burroughs Wellcome Co | Pyrido (2,3-d) pyrimidines and method of preparing same |
| US2926166A (en) * | 1954-01-04 | 1960-02-23 | Burroughs Wellcome Co | Pyrido (2, 3-d) pyrimidine compounds and method of making |
| US2802826A (en) * | 1955-07-13 | 1957-08-13 | Hoffmann La Roche | Octahydro-pyrido [4, 3-d] pyrimidine compounds |
| US2890152A (en) * | 1956-11-29 | 1959-06-09 | Schering Corp | Topical anti-inflammatory compositions |
| US2994640A (en) * | 1957-02-22 | 1961-08-01 | Byk Gulden Lomberg Chem Fab | Anti-inflammatory therapy with purine molecular compounds |
| US3149106A (en) * | 1962-02-23 | 1964-09-15 | Smith Kline French Lab | Method of preparation of heterocyclic compounds |
-
0
- CA CA764962A patent/CA764962A/en not_active Expired
-
1962
- 1962-03-22 DE DET21812A patent/DE1285478B/de active Pending
-
1963
- 1963-03-11 CH CH302863A patent/CH435305A/de unknown
- 1963-03-14 US US265051A patent/US3306901A/en not_active Expired - Lifetime
- 1963-03-18 GB GB10640/63A patent/GB1033383A/en not_active Expired
- 1963-03-20 FR FR928686A patent/FR2928M/fr not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001044246A1 (en) * | 1999-12-17 | 2001-06-21 | Chiron Corporation | Bicyclic inhibitors of glycogen synthase kinase 3 |
| US6800632B2 (en) | 1999-12-17 | 2004-10-05 | Chiron Corporation | Bicyclic inhibitors of glycogen synthase kinase 3 |
| EP1607396A1 (en) * | 1999-12-17 | 2005-12-21 | Chiron Corporation | Bicyclic inhibitors of glycogen synthase kinase 3 |
| CN100335479C (zh) * | 1999-12-17 | 2007-09-05 | 希龙公司 | 糖元合成酶激酶3的双环抑制剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| US3306901A (en) | 1967-02-28 |
| CH435305A (de) | 1967-05-15 |
| DE1285478B (de) | 1968-12-19 |
| FR2928M (enExample) | 1964-12-18 |
| CA764962A (en) | 1967-08-08 |
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