GB1029999A - Process for the manufacture of a growth-promoting substance - Google Patents
Process for the manufacture of a growth-promoting substanceInfo
- Publication number
- GB1029999A GB1029999A GB1307963A GB1307963A GB1029999A GB 1029999 A GB1029999 A GB 1029999A GB 1307963 A GB1307963 A GB 1307963A GB 1307963 A GB1307963 A GB 1307963A GB 1029999 A GB1029999 A GB 1029999A
- Authority
- GB
- United Kingdom
- Prior art keywords
- coprogen
- penicillium
- desferricoprogen
- iron
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000126 substance Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 6
- FQIVLXIUJLOKPL-DWZMLRRXSA-N coprogen Chemical compound C1CCN(O2)C(=O)\C=C(C)\CCOC(=O)[C@@H](NC(=O)C)CCCN(C(=O)\C=C(/C)CCO)O[Fe]2ON(C(=O)\C=C(/C)CCO)CCC[C@H]2C(=O)N[C@@H]1C(=O)N2 FQIVLXIUJLOKPL-DWZMLRRXSA-N 0.000 abstract 5
- AKLLFACZGZTMGS-FCRFISLRSA-N desferricoprogen Chemical compound OCCC(/C)=C/C(=O)N(O)CCC[C@H](NC(=O)C)C(=O)OCC\C(C)=C\C(=O)N(O)CCC[C@@H]1NC(=O)[C@H](CCCN(O)C(=O)\C=C(/C)CCO)NC1=O AKLLFACZGZTMGS-FCRFISLRSA-N 0.000 abstract 4
- 229910052742 iron Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 241000228150 Penicillium chrysogenum Species 0.000 abstract 2
- 235000015097 nutrients Nutrition 0.000 abstract 2
- 239000005725 8-Hydroxyquinoline Substances 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910021578 Iron(III) chloride Inorganic materials 0.000 abstract 1
- 241000228147 Penicillium camemberti Species 0.000 abstract 1
- 235000002245 Penicillium camembertii Nutrition 0.000 abstract 1
- 241000228153 Penicillium citrinum Species 0.000 abstract 1
- 241001149507 Penicillium urticae Species 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- -1 ferric chloride Chemical class 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 150000002505 iron Chemical class 0.000 abstract 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229960003540 oxyquinoline Drugs 0.000 abstract 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000000638 solvent extraction Methods 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G11/00—Antibiotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Coprogen and desferricoprogen are manufactured by growing Penicillium citrinum M 3614, Penicillium camemberti M 98, Penicillium urticae 4277, Penicillium notatum 1613 or Penicillium chrysogenum 4360 under aerobic conditions in an aqueous nutrient solution containing a carbon source and a nitrogen source and one or more inorganic salts. Coprogen and/or desferricoprogen are isolated from the culture filtrate and desferricoprogen may be converted to coprogen by addition of an iron salt, e.g. ferric chloride, or desferricoprogen may be obtained from coprogen by removing iron with an iron complex-forming substance, e.g. 8-hydroxyquinoline. The nutrient medium preferably contains less than 10-7 mol./litre of iron. The coprogen may be isolated by adsorption or by solvent extraction. Examples are given.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH418862A CH437639A (en) | 1962-04-05 | 1962-04-05 | Process for the production of coprogen and desferricoprogen |
| CH1354762A CH466503A (en) | 1962-11-19 | 1962-11-19 | Process for the production of coprogen and desferricoprogen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1029999A true GB1029999A (en) | 1966-05-18 |
Family
ID=25694876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1307963A Expired GB1029999A (en) | 1962-04-05 | 1963-04-02 | Process for the manufacture of a growth-promoting substance |
Country Status (4)
| Country | Link |
|---|---|
| DK (1) | DK104508C (en) |
| FR (1) | FR1355923A (en) |
| GB (1) | GB1029999A (en) |
| SE (1) | SE330589B (en) |
-
1963
- 1963-04-02 GB GB1307963A patent/GB1029999A/en not_active Expired
- 1963-04-04 DK DK158163A patent/DK104508C/en active
- 1963-04-05 FR FR930501A patent/FR1355923A/en not_active Expired
- 1963-04-05 SE SE381063A patent/SE330589B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SE330589B (en) | 1970-11-23 |
| FR1355923A (en) | 1964-03-20 |
| DK104508C (en) | 1966-05-31 |
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