GB975771A - The antibiotic porfiromycin - Google Patents

The antibiotic porfiromycin

Info

Publication number
GB975771A
GB975771A GB3459/61A GB345961A GB975771A GB 975771 A GB975771 A GB 975771A GB 3459/61 A GB3459/61 A GB 3459/61A GB 345961 A GB345961 A GB 345961A GB 975771 A GB975771 A GB 975771A
Authority
GB
United Kingdom
Prior art keywords
porfiromycin
antibiotic
water
pict
animals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3459/61A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB975771A publication Critical patent/GB975771A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Abstract

<PICT:0975771/C1/1> <PICT:0975771/C1/2> The antibiotic porfiromycin is prepared by cultivating a porfiromycin-producing strain of Streptomyces ardus especially S. ardus NRRL 2817 in an aqueous nutrient medium containing a source of carbon and nitrogen under aerobic preferably submerged aerobic conditions until substantial porfiromycin activity is imparted to said medium. Cultivation may be carried out at 18-40 DEG C. for 2-10 days. The antibiotic is isolated by extracting the culture filtrate with a water-immiscible organic solvent e.g. ethyl acetate. The antibiotic may be purified by (a) countercurrent distribution with water and ethyl acetate (1:1) (b) adsorption on to alumina or carbon and elution. The antibiotic Porfiromycin is effective in inhibiting the growth of gram negative and gram positive bacteria and when isolated in the pure form is characterized by (a) forming dark purple crystals melting at 201-201.5 DEG C. (b) empirical formula C16H20N4O5 (c) a paper strip mobility as shown in Fig. 2. (d) an I.R. spectrum as shown in Fig. I (e) elemental analysis C=55.44 H=6.00 N=15.98 O=23.06 (f) [a ]25D=275 DEG \sB55 (C=0.01% methanol) and [a ]25430= +2525 DEG \sB50 (C=0.02% methanol) (g) U.V. maxima at 217, 248, 364 +575mm and (h) being soluble in water, water-immiscible polar organic solvents + water-miscible organic solvents and relatively insoluble in diethyl ether, toluene and cyclohexane. The antibiotic may be added to the feed and drinking water of animals and fish as a prophylactic.ALSO:Porfiromycin (see Division C2) is fed to animals and birds e.g in their feed or drinking water to promote the growth thereof.ALSO:Aqueous solutions of porfiromycin (see Division C2) are used to disinfect instruments, rooms, clothes, paper and fabric by washing.
GB3459/61A 1960-02-23 1961-01-30 The antibiotic porfiromycin Expired GB975771A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1046160A 1960-02-23 1960-02-23
US6024260A 1960-09-21 1960-09-21

Publications (1)

Publication Number Publication Date
GB975771A true GB975771A (en) 1964-11-18

Family

ID=26681204

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3459/61A Expired GB975771A (en) 1960-02-23 1961-01-30 The antibiotic porfiromycin

Country Status (1)

Country Link
GB (1) GB975771A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014062856A1 (en) 2012-10-16 2014-04-24 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods

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