GB1029749A - 1,2ª‡-methylene steroids and a process for their manufacture - Google Patents
1,2ª‡-methylene steroids and a process for their manufactureInfo
- Publication number
- GB1029749A GB1029749A GB15230/65A GB1523065A GB1029749A GB 1029749 A GB1029749 A GB 1029749A GB 15230/65 A GB15230/65 A GB 15230/65A GB 1523065 A GB1523065 A GB 1523065A GB 1029749 A GB1029749 A GB 1029749A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- saturated
- methylene
- acid
- alkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 1a ,2a -methylene-5a -androstane derivatives of the formula <FORM:1029749/C2/1> in which R1 represents a hydrogen atom or an acyl radical and R2 represents a saturated or unsaturated low alkyl radical containing 1-4 carbon atoms, and a process for the preparation thereof wherein a saturated or unsaturated alkyl group is introduced into 1,2a -methylene-5a - androstan - 17 - one by subjecting the 17-keto group to the Grignard reaction, or an alkynyl group is introduced in an analogous manner, and may, if desired, be reduced to the corresponding vinyl or saturated alkyl group, and depending on what group R1 is to represent, the primary steroid alcohol formed may be esterified with the desired acid or with a reactive acid derivative of said acid. Pharmaceutical compositions having anabolic and anti-fertility activity and containing the above compounds are administered orally in tablets, dragees, capsules, pills, suspensions or solutions.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DESCH35037A DE1226574B (en) | 1964-04-25 | 1964-04-25 | Process for the preparation of 1,2alpha-methylene-5alpha-androstane derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1029749A true GB1029749A (en) | 1966-05-18 |
Family
ID=7433348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB15230/65A Expired GB1029749A (en) | 1964-04-25 | 1965-04-09 | 1,2ª‡-methylene steroids and a process for their manufacture |
Country Status (5)
Country | Link |
---|---|
US (1) | US3354185A (en) |
CH (1) | CH471828A (en) |
DE (1) | DE1226574B (en) |
GB (1) | GB1029749A (en) |
NL (1) | NL6505072A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470156A (en) * | 1967-01-30 | 1969-09-30 | Smithkline Corp | 6,6-ethylene-1,2-methylenesteroids |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3163663A (en) * | 1961-12-04 | 1964-12-29 | Syntex Corp | 2alpha-methyl-delta3-androstene-17-hydrocarbon derivatives |
US3254099A (en) * | 1962-03-05 | 1966-05-31 | Rhone Poulenc Sa | 17alpha-substituted-17beta-hydroxy androstane and androstene derivatives |
DE1187611B (en) * | 1963-07-13 | 1965-02-25 | Schering Ag | Process for the preparation of 3-esters or 3-ethers of 1alpha, 2alpha-methylene-delten-3, 17beta-diols and their 17beta-esters |
-
1964
- 1964-04-25 DE DESCH35037A patent/DE1226574B/en active Pending
-
1965
- 1965-03-31 CH CH445065A patent/CH471828A/en not_active IP Right Cessation
- 1965-04-09 GB GB15230/65A patent/GB1029749A/en not_active Expired
- 1965-04-16 US US448854A patent/US3354185A/en not_active Expired - Lifetime
- 1965-04-21 NL NL6505072A patent/NL6505072A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE1226574B (en) | 1966-10-13 |
CH471828A (en) | 1969-04-30 |
US3354185A (en) | 1967-11-21 |
NL6505072A (en) | 1965-10-26 |
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