GB1027746A - 17-amino-androstane and -androstene derivatives - Google Patents
17-amino-androstane and -androstene derivativesInfo
- Publication number
- GB1027746A GB1027746A GB49140/62A GB4914062A GB1027746A GB 1027746 A GB1027746 A GB 1027746A GB 49140/62 A GB49140/62 A GB 49140/62A GB 4914062 A GB4914062 A GB 4914062A GB 1027746 A GB1027746 A GB 1027746A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- alkyl
- hydrogen atom
- atom
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of formula <FORM:1027746/C2/1> wherein R1 is an a or b -hydroxy group and R2 is a hydrogen atom or R1 and R2 together represent an oxygen atom, R3 is a C2- 6 alkyl group, a phenyl (C1- 6 alkyl) group or a C3- 8 cycloalkyl group, and R4 is a hydrogen atom, a C1- 6 alkyl group or a phenyl (C1- 6 alkyl) group, or the group -NR3R4 forms a 5-, 6- or 7-membered heterocyclic ring which may contain an oxygen or additional nitrogen hetero-atom, which latter may be substituted by a C1- 6 alkyl group or a group-COR where R is a C1- 6 alkyl or alkoxy group, and T1, T2 and T3 are hydrogen atoms or T1 and T2 or T2 and T3 form a bond, the remaining T symbols representing a hydrogen atom, acid addition salts and, wherein R4 is other than hydrogen, C1- 6 alkyl quaternary ammonium salts thereof, and their preparation by reductive amination of a compound of formula <FORM:1027746/C2/2> wherein R11 is an a - or b -hydroxy group and R21 is a hydrogen atom, followed if desired by (a) oxidation to a 3-keto group, (b) catalytic hydrogenation of a D 4 or D 5 double bond, or (c) interconversion of the 17-amino group by known methods, for example alkylation or aralkylation. The compounds of the invention have central nervous system stimulant activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral or parenteral administration, such as tablets, pills, granules, dispersible powders, syrups, elixirs, solutions, suspensions and ampoules.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL302932D NL302932A (en) | 1962-12-31 | ||
GB49140/62A GB1027746A (en) | 1962-12-31 | 1962-12-31 | 17-amino-androstane and -androstene derivatives |
ES294887A ES294887A1 (en) | 1962-12-31 | 1963-12-27 | Procedure for the preparation of steroid derivatives (Machine-translation by Google Translate, not legally binding) |
FR958854A FR1432523A (en) | 1962-12-31 | 1963-12-30 | New steroid derivatives |
BE642020A BE642020A (en) | 1962-12-31 | 1963-12-31 | |
FR959970A FR3159M (en) | 1962-12-31 | 1964-01-10 | New steroid derivatives. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB49140/62A GB1027746A (en) | 1962-12-31 | 1962-12-31 | 17-amino-androstane and -androstene derivatives |
GB220063 | 1963-01-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1027746A true GB1027746A (en) | 1966-04-27 |
Family
ID=26237361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB49140/62A Expired GB1027746A (en) | 1962-12-31 | 1962-12-31 | 17-amino-androstane and -androstene derivatives |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE642020A (en) |
ES (1) | ES294887A1 (en) |
FR (2) | FR1432523A (en) |
GB (1) | GB1027746A (en) |
NL (1) | NL302932A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63284195A (en) * | 1987-04-22 | 1988-11-21 | メレルダウファーマスーティカルズ インコーポレーテッド | 17beta-(cyclopropylamino)androst-5-ene-3beta-ol useful as c17-20 liase inhibitor and related compound |
US4954488A (en) * | 1989-06-14 | 1990-09-04 | Merrell Dow Pharmaceuticals Inc. | Method of treating hyperaldosteronism using 17β-cyclopropylaminoandrostene derivatives |
US4966898A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
US5075464A (en) * | 1987-04-22 | 1991-12-24 | Merrell Dow Pharmaceuticals Inc. | 17β-(cyclopropylamino)androstene derivatives |
-
0
- NL NL302932D patent/NL302932A/xx unknown
-
1962
- 1962-12-31 GB GB49140/62A patent/GB1027746A/en not_active Expired
-
1963
- 1963-12-27 ES ES294887A patent/ES294887A1/en not_active Expired
- 1963-12-30 FR FR958854A patent/FR1432523A/en not_active Expired
- 1963-12-31 BE BE642020A patent/BE642020A/xx unknown
-
1964
- 1964-01-10 FR FR959970A patent/FR3159M/en not_active Expired
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63284195A (en) * | 1987-04-22 | 1988-11-21 | メレルダウファーマスーティカルズ インコーポレーテッド | 17beta-(cyclopropylamino)androst-5-ene-3beta-ol useful as c17-20 liase inhibitor and related compound |
US5075464A (en) * | 1987-04-22 | 1991-12-24 | Merrell Dow Pharmaceuticals Inc. | 17β-(cyclopropylamino)androstene derivatives |
JP2711672B2 (en) | 1987-04-22 | 1998-02-10 | メレルダウファーマスーティカルズ インコーポレーテッド | 17β- (cyclopropylamino) androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
US4954488A (en) * | 1989-06-14 | 1990-09-04 | Merrell Dow Pharmaceuticals Inc. | Method of treating hyperaldosteronism using 17β-cyclopropylaminoandrostene derivatives |
US4966898A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
NL302932A (en) | |
FR1432523A (en) | 1966-03-25 |
BE642020A (en) | 1964-06-30 |
ES294887A1 (en) | 1964-04-16 |
FR3159M (en) | 1965-03-01 |
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