GB1017691A - Amines - Google Patents

Amines

Info

Publication number
GB1017691A
GB1017691A GB38917/61A GB3891761A GB1017691A GB 1017691 A GB1017691 A GB 1017691A GB 38917/61 A GB38917/61 A GB 38917/61A GB 3891761 A GB3891761 A GB 3891761A GB 1017691 A GB1017691 A GB 1017691A
Authority
GB
United Kingdom
Prior art keywords
stands
stand
formula
cases
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB38917/61A
Inventor
Arthur Donald Ainley
Ralph Howe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB38917/61A priority Critical patent/GB1017691A/en
Priority to FR923205A priority patent/FR2740M/en
Publication of GB1017691A publication Critical patent/GB1017691A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:1017691/C2/1> (wherein R1 and R2, which may be the same or different, stand for alkyl, alkenyl, aralkyl or haloaralkyl radicals, wherein R3, R4 and R5, which may be the same or different, stand for hydrogen atoms or alkyl radicals, and wherein the benzene ring A may optionally be further substituted by one or more halogen atoms) and acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by (a)-in cases where R4 and R5 stand for hydrogen atoms-reducing a compound of the formula <FORM:1017691/C2/2> (b)-in cases where R4 stands for a hydrogen atom and R5 stands for an alkyl radical of the formula CHR6R7, wherein R6 and R7, which may be the same or different, stand for hydrogen atoms or alkyl radicals, or wherein R4 and R5 both stand for methyl radicals-reacting a compound of the formula <FORM:1017691/C2/3> (which may be generated in situ) or a salt thereof with R6R7CO under reducing conditions, (c)-in cases where R4 stands for a hydrogen atom and R5 stands for an alkyl radical other than a methyl radical-reducing a compound of the formula <FORM:1017691/C2/4> (wherein R8 stands for an alkyl radical), or (d)-in cases where R1 stands for an alkyl radical-reducing the corresponding compound wherein R1 stands for an alkenyl radical, optionally followed in each case by acid addition salt formation. The starting materials for process (a) are prepared by reacting the corresponding b -nitrostyrene derivative with a corresponding alkali metal alkoxide. The preparation of 3-allyloxybenzaldehyde, 3 - (4 - chlorobenzyloxy) benzaldehyde and N - butyryl - 2 - methoxy - 2 - (3 - methoxyphenyl) - ethylamine is also described. The compounds of the invention possess hypotensive properties and may be adminitered orally or parenterally in the form of pharmaceutical preparations (e.g. tablets, capsules, solutions, suspensions, emulsions and dispersible powders) containing them together with a diluent or carrier.
GB38917/61A 1961-10-31 1961-10-31 Amines Expired GB1017691A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB38917/61A GB1017691A (en) 1961-10-31 1961-10-31 Amines
FR923205A FR2740M (en) 1961-10-31 1963-01-30 Amines derived from hypotensive drugs.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB38917/61A GB1017691A (en) 1961-10-31 1961-10-31 Amines

Publications (1)

Publication Number Publication Date
GB1017691A true GB1017691A (en) 1966-01-19

Family

ID=10406479

Family Applications (1)

Application Number Title Priority Date Filing Date
GB38917/61A Expired GB1017691A (en) 1961-10-31 1961-10-31 Amines

Country Status (2)

Country Link
FR (1) FR2740M (en)
GB (1) GB1017691A (en)

Also Published As

Publication number Publication date
FR2740M (en) 1964-08-24

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