GB1010240A - Benzoic acid derivatives - Google Patents

Benzoic acid derivatives

Info

Publication number
GB1010240A
GB1010240A GB1093763A GB1093763A GB1010240A GB 1010240 A GB1010240 A GB 1010240A GB 1093763 A GB1093763 A GB 1093763A GB 1093763 A GB1093763 A GB 1093763A GB 1010240 A GB1010240 A GB 1010240A
Authority
GB
United Kingdom
Prior art keywords
cyanide
nitrile
carried out
benzoic acid
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1093763A
Inventor
Cornelis Van Der Stelt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Pharmaceutische Fabrieken NV
Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Pharmaceutische Fabrieken NV filed Critical Koninklijke Pharmaceutische Fabrieken NV
Priority to GB1093763A priority Critical patent/GB1010240A/en
Priority to NL6402896A priority patent/NL6402896A/xx
Publication of GB1010240A publication Critical patent/GB1010240A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

o-, m- and p-Trifluoromethyl benzoic acids are prepared by reacting the corresponding chloro-substituted trifluoromethylbenzene with a metal cyanide, e.g. cuprous cyanide, and saponifying the resulting trifluoromethyl benzonitrile. The reaction between the chlorocompound and the metal cyanide is preferably carried out by heating the reactants under superatmospheric pressure in an inert organic solvent, e.g. N-methylpyrrolidone, dimethylformamide, dimethylsulphoxide and sulpholane. The saponification of the nitrile is carried out in known manner, e.g. by refluxing the nitrile with a solution of an alkali metal hydroxide in a mixture of water and alcohol. Some trifluoromethylbenzoic acid amide may be obtained as a by-product in the formation of the cyanide.
GB1093763A 1963-03-19 1963-03-19 Benzoic acid derivatives Expired GB1010240A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB1093763A GB1010240A (en) 1963-03-19 1963-03-19 Benzoic acid derivatives
NL6402896A NL6402896A (en) 1963-03-19 1964-03-18

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1093763A GB1010240A (en) 1963-03-19 1963-03-19 Benzoic acid derivatives

Publications (1)

Publication Number Publication Date
GB1010240A true GB1010240A (en) 1965-11-17

Family

ID=9977049

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1093763A Expired GB1010240A (en) 1963-03-19 1963-03-19 Benzoic acid derivatives

Country Status (2)

Country Link
GB (1) GB1010240A (en)
NL (1) NL6402896A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5113013A (en) * 1989-04-26 1992-05-12 Imperial Chemical Industries Plc Process for preparing fluorine-containing organic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5113013A (en) * 1989-04-26 1992-05-12 Imperial Chemical Industries Plc Process for preparing fluorine-containing organic compounds

Also Published As

Publication number Publication date
NL6402896A (en) 1964-09-21

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