GB1005893A - Quinoline derivatives - Google Patents

Quinoline derivatives

Info

Publication number
GB1005893A
GB1005893A GB31388/63A GB3138863A GB1005893A GB 1005893 A GB1005893 A GB 1005893A GB 31388/63 A GB31388/63 A GB 31388/63A GB 3138863 A GB3138863 A GB 3138863A GB 1005893 A GB1005893 A GB 1005893A
Authority
GB
United Kingdom
Prior art keywords
branched
carbon atoms
aliphatic hydrocarbon
hydrocarbon group
chain aliphatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31388/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of GB1005893A publication Critical patent/GB1005893A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of formula <FORM:1005893/C2/1> wherein A is a divalent straight- or branched-chain aliphatic hydrocarbon group having 2 to 6 carbon atoms, B is a single bond or a group -A1-NH, wherein the nitrogen atom is attached to the quinoline nucleus and A1 is a divalent straight or branched-chain aliphatic hydrocarbon group having 2 to 6 carbon atoms, non-toxic acid addition salts thereof, and their preparation by oxidation of the corresponding piperazine derivatives. The compounds of the invention have anti-malarial activity and may be used in pharmaceutical compositions in combination with a carrier, for example in forms suitable for oral, parenteral or rectal administration, such as tablets, pills, powders, granules, capsules, emulsions, solutions, suspensions, syrups, elixirs or suppositories. Specifications 973,903, 986,350 and 1,002,187 are referred to.
GB31388/63A 1962-08-13 1963-08-08 Quinoline derivatives Expired GB1005893A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR906819A FR1405217A (en) 1962-08-13 1962-08-13 New quinoline derivatives and their preparation

Publications (1)

Publication Number Publication Date
GB1005893A true GB1005893A (en) 1965-09-29

Family

ID=8785091

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31388/63A Expired GB1005893A (en) 1962-08-13 1963-08-08 Quinoline derivatives

Country Status (9)

Country Link
AT (1) AT242142B (en)
BE (1) BE636091A (en)
CH (1) CH412909A (en)
DK (1) DK103187C (en)
ES (1) ES290157A1 (en)
FR (2) FR1405217A (en)
GB (1) GB1005893A (en)
LU (1) LU43902A1 (en)
NL (1) NL296359A (en)

Also Published As

Publication number Publication date
LU43902A1 (en) 1963-08-14
NL296359A (en) 1965-05-10
FR1405217A (en) 1965-07-09
CH412909A (en) 1966-05-15
DK103187C (en) 1965-11-29
FR2371M (en) 1964-04-03
AT242142B (en) 1965-08-25
ES290157A1 (en) 1963-12-16
BE636091A (en) 1964-02-12

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