GB1005025A - Naphthalene derivatives - Google Patents
Naphthalene derivativesInfo
- Publication number
- GB1005025A GB1005025A GB46034/61A GB4603461A GB1005025A GB 1005025 A GB1005025 A GB 1005025A GB 46034/61 A GB46034/61 A GB 46034/61A GB 4603461 A GB4603461 A GB 4603461A GB 1005025 A GB1005025 A GB 1005025A
- Authority
- GB
- United Kingdom
- Prior art keywords
- stands
- radical
- alkyl
- substituted
- naphthyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002790 naphthalenes Chemical class 0.000 title abstract 9
- -1 alkyl radical Chemical class 0.000 abstract 20
- 150000001875 compounds Chemical class 0.000 abstract 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 239000002253 acid Substances 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 6
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 150000003254 radicals Chemical class 0.000 abstract 3
- 239000007858 starting material Substances 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- VUQQEZHVXFHPMR-UHFFFAOYSA-N 2-bromotetracene Chemical compound C1=CC=CC2=CC3=CC4=CC(Br)=CC=C4C=C3C=C21 VUQQEZHVXFHPMR-UHFFFAOYSA-N 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000005840 aryl radicals Chemical class 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- NBXAUOVXJOGPFW-UHFFFAOYSA-N 1-(5-methylnaphthalen-2-yl)ethanone Chemical compound CC1=CC=CC2=CC(C(=O)C)=CC=C21 NBXAUOVXJOGPFW-UHFFFAOYSA-N 0.000 abstract 1
- JVUMUVDQPOYSNE-UHFFFAOYSA-N 1-amino-2-cyclohexyl-1-naphthalen-2-ylethanol Chemical compound C1=C(C=CC2=CC=CC=C12)C(CC1CCCCC1)(O)N JVUMUVDQPOYSNE-UHFFFAOYSA-N 0.000 abstract 1
- QKYPISNDVGEHJV-UHFFFAOYSA-N 1-methoxy-3-(1-methoxy-2-nitroethyl)benzene Chemical compound COC(C[N+](=O)[O-])C1=CC(=CC=C1)OC QKYPISNDVGEHJV-UHFFFAOYSA-N 0.000 abstract 1
- IJBGIPFDIABTKB-AATRIKPKSA-N 1-methoxy-3-[(e)-2-nitroethenyl]benzene Chemical compound COC1=CC=CC(\C=C\[N+]([O-])=O)=C1 IJBGIPFDIABTKB-AATRIKPKSA-N 0.000 abstract 1
- VHVGAGIWTBHQLD-UHFFFAOYSA-N 1-naphthalen-2-yl-2-(1-phenylpropan-2-ylamino)ethanone hydrobromide Chemical compound Br.CC(CC1=CC=CC=C1)NCC(=O)C1=CC2=CC=CC=C2C=C1 VHVGAGIWTBHQLD-UHFFFAOYSA-N 0.000 abstract 1
- BVOHJSFNVVLONO-UHFFFAOYSA-N 1-naphthalen-2-yl-2-(2-phenylethylamino)ethanol Chemical compound C1=C(C=CC2=CC=CC=C12)C(CNCCC1=CC=CC=C1)O BVOHJSFNVVLONO-UHFFFAOYSA-N 0.000 abstract 1
- NBHSAWIIABZCSJ-UHFFFAOYSA-N 1-naphthalen-2-yl-2-piperidin-1-ylethanol Chemical compound C=1C=C2C=CC=CC2=CC=1C(O)CN1CCCCC1 NBHSAWIIABZCSJ-UHFFFAOYSA-N 0.000 abstract 1
- KWTSXDURSIMDCE-UHFFFAOYSA-N 1-phenylpropan-2-amine Chemical compound CC(N)CC1=CC=CC=C1 KWTSXDURSIMDCE-UHFFFAOYSA-N 0.000 abstract 1
- FMIQMLLUSAXQKG-UHFFFAOYSA-N 2,2-dihydroxy-1-naphthalen-2-ylethanone Chemical compound C1=CC=CC2=CC(C(=O)C(O)O)=CC=C21 FMIQMLLUSAXQKG-UHFFFAOYSA-N 0.000 abstract 1
- CTNYAHYHHWIJAG-UHFFFAOYSA-N 2-(benzylamino)-1-naphthalen-2-ylethanol Chemical compound C=1C=C2C=CC=CC2=CC=1C(O)CNCC1=CC=CC=C1 CTNYAHYHHWIJAG-UHFFFAOYSA-N 0.000 abstract 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 abstract 1
- PGJHAXAIVJIVSM-UHFFFAOYSA-N 2-amino-1-naphthalen-2-ylethanol Chemical compound C1=CC=CC2=CC(C(O)CN)=CC=C21 PGJHAXAIVJIVSM-UHFFFAOYSA-N 0.000 abstract 1
- HAWGOBNOKCAJHF-UHFFFAOYSA-N 2-bromo-6-methyltetracene Chemical compound CC1=C2C=C3C=CC(=CC3=CC2=CC2=CC=CC=C12)Br HAWGOBNOKCAJHF-UHFFFAOYSA-N 0.000 abstract 1
- SVRFEXNTXJGYNU-UHFFFAOYSA-N 2-methoxy-2-(3-methoxyphenyl)ethanamine;hydrochloride Chemical compound Cl.COC(CN)C1=CC=CC(OC)=C1 SVRFEXNTXJGYNU-UHFFFAOYSA-N 0.000 abstract 1
- UQDNOKHEJBXEEI-UHFFFAOYSA-N 2-morpholin-4-yl-1-naphthalen-2-ylethanol Chemical compound C=1C=C2C=CC=CC2=CC=1C(O)CN1CCOCC1 UQDNOKHEJBXEEI-UHFFFAOYSA-N 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- UXPVTYJZHSTTNN-UHFFFAOYSA-N 3-(2-hydroxy-2-naphthalen-2-ylethyl)-2-methyl-1,2-dihydropyrrol-5-one Chemical compound CC1C(=CC(=O)N1)CC(C2=CC3=CC=CC=C3C=C2)O UXPVTYJZHSTTNN-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- GMEONFUTDYJSNV-UHFFFAOYSA-N Ethyl levulinate Chemical compound CCOC(=O)CCC(C)=O GMEONFUTDYJSNV-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE626434D BE626434A (enrdf_load_stackoverflow) | 1961-12-22 | ||
| NL287141D NL287141A (enrdf_load_stackoverflow) | 1961-12-22 | ||
| GB46034/61A GB1005025A (en) | 1961-12-22 | 1961-12-22 | Naphthalene derivatives |
| DK551163A DK105534C (da) | 1961-12-22 | 1962-12-21 | Fremgangsmåde til fremstilling af 1-(2-naftyl)-2-aminoætanolderivater eller salte deraf. |
| ES283604A ES283604A1 (es) | 1961-12-22 | 1962-12-21 | Procedimiento de obtención de derivados de naftaleno |
| AT247864A AT240848B (de) | 1961-12-22 | 1962-12-21 | Verfahren zur Herstellung von neuen 1-(β-Naphthyl)-2-aminoäthanolderivaten und Salzen dieser Verbindungen |
| DK551363A DK104631C (da) | 1961-12-22 | 1962-12-21 | Fremgangsmåde til fremstilling af 1-(2-naftyl)-2-aminoætanolderivater eller salte deraf. |
| AT1002362A AT238714B (de) | 1961-12-22 | 1962-12-21 | Verfahren zur Herstellung von neuen 1-(β-Naphthyl)-2-aminoäthanolderivaten sowie Salzen dieser Verbindungen |
| AT247764A AT245564B (de) | 1961-12-22 | 1962-12-21 | Verfahren zur Herstellung von neuen 1-(β-Naphthyl)-2-aminoäthanolderivaten |
| DK551263A DK105535C (da) | 1961-12-22 | 1962-12-21 | Fremgangsmåde til fremstilling af 1-(2-naftyl)-2-aminoætanolderivater eller salte deraf. |
| AT247664A AT238715B (de) | 1961-12-22 | 1962-12-21 | Verfahren zur Herstellung von neuen 1-(β-Naphthyl)-2-aminoäthanolderivaten sowie Salzen dieser Verbindungen |
| DK558562A DK104309C (da) | 1961-12-22 | 1962-12-21 | Fremgangsmåde til fremstilling af 1-(2-naftyl)-2-aminoætanolderivater eller salte deraf. |
| FR919606A FR1516716A (fr) | 1961-12-22 | 1962-12-22 | Dérivés du naphtalène et leur procédé de fabrication |
| FR928815A FR3913M (enrdf_load_stackoverflow) | 1961-12-22 | 1963-03-21 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB46034/61A GB1005025A (en) | 1961-12-22 | 1961-12-22 | Naphthalene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1005025A true GB1005025A (en) | 1965-09-22 |
Family
ID=10439573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB46034/61A Expired GB1005025A (en) | 1961-12-22 | 1961-12-22 | Naphthalene derivatives |
Country Status (6)
| Country | Link |
|---|---|
| AT (2) | AT238714B (enrdf_load_stackoverflow) |
| BE (1) | BE626434A (enrdf_load_stackoverflow) |
| ES (1) | ES283604A1 (enrdf_load_stackoverflow) |
| FR (1) | FR3913M (enrdf_load_stackoverflow) |
| GB (1) | GB1005025A (enrdf_load_stackoverflow) |
| NL (1) | NL287141A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770615A (en) * | 1996-04-04 | 1998-06-23 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| US5776983A (en) * | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108653736A (zh) * | 2018-04-28 | 2018-10-16 | 中国人民解放军第二军医大学 | M2型丙酮酸激酶作为药物靶点在制备防治银屑病的药物中的应用 |
-
0
- NL NL287141D patent/NL287141A/xx unknown
- BE BE626434D patent/BE626434A/xx unknown
-
1961
- 1961-12-22 GB GB46034/61A patent/GB1005025A/en not_active Expired
-
1962
- 1962-12-21 AT AT1002362A patent/AT238714B/de active
- 1962-12-21 ES ES283604A patent/ES283604A1/es not_active Expired
- 1962-12-21 AT AT247864A patent/AT240848B/de active
-
1963
- 1963-03-21 FR FR928815A patent/FR3913M/fr not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5776983A (en) * | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| US5770615A (en) * | 1996-04-04 | 1998-06-23 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
Also Published As
| Publication number | Publication date |
|---|---|
| ES283604A1 (es) | 1963-05-01 |
| FR3913M (enrdf_load_stackoverflow) | 1966-02-14 |
| BE626434A (enrdf_load_stackoverflow) | |
| AT238714B (de) | 1965-02-25 |
| AT240848B (de) | 1965-06-25 |
| NL287141A (enrdf_load_stackoverflow) |
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