GB1000405A - Therapeutic derivatives of aralkyl-2-mercaptobenzazoles - Google Patents
Therapeutic derivatives of aralkyl-2-mercaptobenzazolesInfo
- Publication number
- GB1000405A GB1000405A GB22853/62A GB2285362A GB1000405A GB 1000405 A GB1000405 A GB 1000405A GB 22853/62 A GB22853/62 A GB 22853/62A GB 2285362 A GB2285362 A GB 2285362A GB 1000405 A GB1000405 A GB 1000405A
- Authority
- GB
- United Kingdom
- Prior art keywords
- diethylaminoethoxy
- methyl
- chloro
- naa
- benzaldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- ZJWDEMJHVZBLFG-UHFFFAOYSA-N 1,2-dichloro-n,n-diethylethanamine Chemical compound CCN(CC)C(Cl)CCl ZJWDEMJHVZBLFG-UHFFFAOYSA-N 0.000 abstract 1
- FVRYCPZDHKLBNR-UHFFFAOYSA-N 2-mercaptoindole Chemical compound C1=CC=C2NC(S)=CC2=C1 FVRYCPZDHKLBNR-UHFFFAOYSA-N 0.000 abstract 1
- IXYXUAKJHBRGOR-UHFFFAOYSA-N 3-chloro-4-[2-(diethylamino)ethoxy]benzaldehyde Chemical compound CCN(CC)CCOC1=CC=C(C=O)C=C1Cl IXYXUAKJHBRGOR-UHFFFAOYSA-N 0.000 abstract 1
- -1 3-chloro-4-diethylaminoethoxy-benzyl Chemical group 0.000 abstract 1
- VGSOCYWCRMXQAB-UHFFFAOYSA-N 3-chloro-4-hydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1Cl VGSOCYWCRMXQAB-UHFFFAOYSA-N 0.000 abstract 1
- NYCUSYCCGKZKBM-UHFFFAOYSA-N 4-[2-(diethylamino)ethoxy]benzaldehyde Chemical compound CCN(CC)CCOC1=CC=C(C=O)C=C1 NYCUSYCCGKZKBM-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- XFOIKBBRGPSDTG-UHFFFAOYSA-N Cl.ClC=1C=C(CCl)C=CC1OCCN(CC)CC Chemical compound Cl.ClC=1C=C(CCl)C=CC1OCCN(CC)CC XFOIKBBRGPSDTG-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 229930040373 Paraformaldehyde Natural products 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 239000002253 acid Chemical group 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N benzyl alcohol Substances OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 1
- 229940073608 benzyl chloride Drugs 0.000 abstract 1
- 150000005524 benzylchlorides Chemical class 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- VXWPONVCMVLXBW-UHFFFAOYSA-M magnesium;carbanide;iodide Chemical compound [CH3-].[Mg+2].[I-] VXWPONVCMVLXBW-UHFFFAOYSA-M 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 229910052760 oxygen Chemical group 0.000 abstract 1
- 229920002866 paraformaldehyde Polymers 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL294107D NL294107A (enrdf_load_stackoverflow) | 1962-06-14 | ||
| BE633672D BE633672A (enrdf_load_stackoverflow) | 1962-06-14 | ||
| GB22853/62A GB1000405A (en) | 1962-06-14 | 1962-06-14 | Therapeutic derivatives of aralkyl-2-mercaptobenzazoles |
| US287186A US3173922A (en) | 1962-06-14 | 1963-06-12 | Therapeutic aminoalkyloxy aralkyl-2-mercaptobenzazoles |
| FR938243A FR3173M (fr) | 1962-06-14 | 1963-06-14 | Dérivés thérapeutiques d'aralcoyl-2-mercapto-benzazoles. |
| FR938242A FR1367733A (fr) | 1962-06-14 | 1963-06-14 | Procédé de préparation d'aralcoyl-2-mercapto-benzazoles et produits conformes à ceux obtenus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB22853/62A GB1000405A (en) | 1962-06-14 | 1962-06-14 | Therapeutic derivatives of aralkyl-2-mercaptobenzazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1000405A true GB1000405A (en) | 1965-08-04 |
Family
ID=10186097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22853/62A Expired GB1000405A (en) | 1962-06-14 | 1962-06-14 | Therapeutic derivatives of aralkyl-2-mercaptobenzazoles |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE633672A (enrdf_load_stackoverflow) |
| FR (1) | FR3173M (enrdf_load_stackoverflow) |
| GB (1) | GB1000405A (enrdf_load_stackoverflow) |
| NL (1) | NL294107A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594425A (en) * | 1984-02-09 | 1986-06-10 | American Home Products Corporation | Heterocyclic compounds as antiallergic agents |
| WO2006007835A3 (de) * | 2004-07-21 | 2006-04-13 | Helmut Kasch | Ammoniumsalze und ammoniumsalz-mineralsalzclathrate als transport- und wirkform für pharmazeutisch-medizinische und als phasentransfermiitel für chemische anwendungen |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873346A (en) * | 1985-09-20 | 1989-10-10 | The Upjohn Company | Substituted benzothiazoles, benzimidazoles, and benzoxazoles |
-
0
- BE BE633672D patent/BE633672A/xx unknown
- NL NL294107D patent/NL294107A/xx unknown
-
1962
- 1962-06-14 GB GB22853/62A patent/GB1000405A/en not_active Expired
-
1963
- 1963-06-14 FR FR938243A patent/FR3173M/fr not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594425A (en) * | 1984-02-09 | 1986-06-10 | American Home Products Corporation | Heterocyclic compounds as antiallergic agents |
| WO2006007835A3 (de) * | 2004-07-21 | 2006-04-13 | Helmut Kasch | Ammoniumsalze und ammoniumsalz-mineralsalzclathrate als transport- und wirkform für pharmazeutisch-medizinische und als phasentransfermiitel für chemische anwendungen |
| RU2417217C2 (ru) * | 2004-07-21 | 2011-04-27 | Хельмут КАШ | Устойчивые и стабильные при хранении солевые кластеры соли аммония и минеральной соли с анионами двухосновных кислот и способ их получения |
Also Published As
| Publication number | Publication date |
|---|---|
| NL294107A (enrdf_load_stackoverflow) | |
| FR3173M (fr) | 1965-03-08 |
| BE633672A (enrdf_load_stackoverflow) |
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