FR3128122A1 - Active principle comprising an extract of Fagopyrum escule n tum acting on the elasticity of the skin, cosmetic compositions comprising it and corresponding uses. - Google Patents
Active principle comprising an extract of Fagopyrum escule n tum acting on the elasticity of the skin, cosmetic compositions comprising it and corresponding uses. Download PDFInfo
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- FR3128122A1 FR3128122A1 FR2110990A FR2110990A FR3128122A1 FR 3128122 A1 FR3128122 A1 FR 3128122A1 FR 2110990 A FR2110990 A FR 2110990A FR 2110990 A FR2110990 A FR 2110990A FR 3128122 A1 FR3128122 A1 FR 3128122A1
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- 239000000284 extract Substances 0.000 title claims abstract description 36
- 239000000203 mixture Substances 0.000 title claims abstract description 27
- 239000002537 cosmetic Substances 0.000 title claims abstract description 17
- 235000009419 Fagopyrum esculentum Nutrition 0.000 title claims abstract description 15
- 241000219051 Fagopyrum Species 0.000 title 1
- 240000008620 Fagopyrum esculentum Species 0.000 claims abstract description 14
- 239000004480 active ingredient Substances 0.000 claims abstract description 6
- 210000003491 skin Anatomy 0.000 claims description 21
- 230000015572 biosynthetic process Effects 0.000 claims description 19
- 238000003786 synthesis reaction Methods 0.000 claims description 19
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims description 14
- 229920002549 elastin Polymers 0.000 claims description 12
- 102000016942 Elastin Human genes 0.000 claims description 10
- 108010014258 Elastin Proteins 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 210000002950 fibroblast Anatomy 0.000 claims description 8
- 229960003624 creatine Drugs 0.000 claims description 7
- 239000006046 creatine Substances 0.000 claims description 7
- 210000004207 dermis Anatomy 0.000 claims description 7
- 230000000699 topical effect Effects 0.000 claims description 5
- 102100040870 Glycine amidinotransferase, mitochondrial Human genes 0.000 claims description 4
- 102100040579 Guanidinoacetate N-methyltransferase Human genes 0.000 claims description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- XOYCLJDJUKHHHS-LHBOOPKSSA-N (2s,3s,4s,5r,6r)-6-[[(2s,3s,5r)-3-amino-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@H](O2)C(O)=O)O)[C@@H](N)C1 XOYCLJDJUKHHHS-LHBOOPKSSA-N 0.000 claims description 2
- 101150108568 ELN gene Proteins 0.000 claims description 2
- 108010073791 Glycine amidinotransferase Proteins 0.000 claims description 2
- 108010070742 Guanidinoacetate N-Methyltransferase Proteins 0.000 claims description 2
- 101150027313 Has2 gene Proteins 0.000 claims description 2
- 101000893303 Homo sapiens Glycine amidinotransferase, mitochondrial Proteins 0.000 claims description 2
- 101000893897 Homo sapiens Guanidinoacetate N-methyltransferase Proteins 0.000 claims description 2
- 102100040206 Hyaluronan synthase 2 Human genes 0.000 claims description 2
- 101710197056 Hyaluronan synthase 2 Proteins 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 230000036074 healthy skin Effects 0.000 claims description 2
- 230000004888 barrier function Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000004936 stimulating effect Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 244000089742 Citrus aurantifolia Species 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 244000207620 Euterpe oleracea Species 0.000 description 2
- 235000012601 Euterpe oleracea Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 230000004132 lipogenesis Effects 0.000 description 2
- 230000004130 lipolysis Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000205585 Aquilegia canadensis Species 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 235000005206 Hibiscus Nutrition 0.000 description 1
- 235000007185 Hibiscus lunariifolius Nutrition 0.000 description 1
- 244000284380 Hibiscus rosa sinensis Species 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 235000007457 Jasminum sambac Nutrition 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 240000005827 Phyllostachys nigra Species 0.000 description 1
- 235000010717 Phyllostachys nigra Nutrition 0.000 description 1
- 241001646982 Thamnolia vermicularis Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 235000003650 acai Nutrition 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 150000003862 amino acid derivatives Chemical class 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000009134 cell regulation Effects 0.000 description 1
- 230000007248 cellular mechanism Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000006353 environmental stress Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000001087 myotubule Anatomy 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
L’invention concerne un principe actif comprenant un extrait de Fagopyrum esculentum agissant sur l’élasticité de la peau. L’invention concerne également les compositions le comprenant. L’invention concerne encore les utilisations cosmétiques d’un tel principe actif et/ou de telles compositions, pour maintenir et/ou rétablir l’élasticité naturelle de la peau.The invention relates to an active principle comprising an extract of Fagopyrum esculentum acting on the elasticity of the skin. The invention also relates to the compositions comprising it. The invention also relates to the cosmetic uses of such an active ingredient and/or of such compositions, for maintaining and/or restoring the natural elasticity of the skin.
Description
Le domaine de l’invention est celui de la cosmétologie. Plus précisément, l’invention concerne un principe actif comprenant un extrait deFagopyrum esculentumagissant sur l’élasticité de la peau, les compositions le comprenant, ainsi que les utilisations cosmétiques d’un tel principe actif et/ou de telles compositions, pour maintenir et/ou rétablir l’élasticité naturelle de la peau.The field of the invention is that of cosmetology. More specifically, the invention relates to an active principle comprising an extract of Fagopyrum esculentum acting on the elasticity of the skin, the compositions comprising it, as well as the cosmetic uses of such an active principle and/or such compositions, for maintaining and/or restore the natural elasticity of the skin.
Un tel principe actif permet en effet de stimuler l’expression de certains gènes impliqués dans la synthèse de l’élastine.Such an active principle makes it possible to stimulate the expression of certain genes involved in the synthesis of elastin.
Art AntérieurPrior Art
Avec l'âge et les expositions chroniques aux stress environnementaux, les fibroblastes du derme de la peau produisent de moins en moins de fibres et d’éléments de la matrice extracellulaire, laquelle est impliquée dans le soutien structural, l'adhérence, le mouvement et la régulation des cellules, et les fibres produites sont de plus en plus endommagées. C’est particulièrement le cas de la peau fine et fragile, telle que celle du contour de l’œil. La synthèse de créatine par les cellules de la peau et la fonction barrière de la peau sont également perturbées.With age and chronic exposure to environmental stresses, fibroblasts in the dermis of the skin produce less and less fibers and elements of the extracellular matrix, which is involved in structural support, adhesion, movement and cell regulation, and the fibers produced are increasingly damaged. This is particularly the case for thin and fragile skin, such as that around the eye area. Creatine synthesis by skin cells and the barrier function of the skin are also disturbed.
Il en résulte une peau qui perd de son élasticité, et qui présente alors un aspect fatigué, stressé, paraissant manquer de vitalité et d’éclat.This results in skin that loses its elasticity, and which then presents a tired, stressed appearance, appearing to lack vitality and radiance.
On connaît dans l’art antérieur de nombreuses compositions cosmétiques intégrant des extraits de plantes ayant une action sur l’élasticité de la peau. Il existe ainsi des compositions cosmétiques ayant des effets d'amélioration de l'élasticité de la peau comprenant un extrait de chèvrefeuille, un extrait de fleur de jasmin arabe et un extrait de peau de pomme. Il existe également de telles compostions comprenant un extrait de son de riz, un extrait de feuille de bambou noir, un extrait d'encens et/ou un extrait de feuille deThamnolia vermicularis. Il existe encore des compositions cosmétiques destinées à améliorer l'élasticité de la peau et à réduire les rides, contenant de l'Euterpe oleracea(palmier açaï), duCitrus aurantiifolia(citron vert), de l'églantier et de l'extrait de fleur d'Hibiscus syriacusascomme ingrédients actifs.Many cosmetic compositions incorporating plant extracts having an action on the elasticity of the skin are known in the prior art. There are thus cosmetic compositions having effects of improving the elasticity of the skin comprising an extract of honeysuckle, an extract of Arabian jasmine flower and an extract of apple skin. There also exist such compositions comprising a rice bran extract, a black bamboo leaf extract, an incense extract and/or a Thamnolia vermicularis leaf extract. There are still cosmetic compositions intended to improve the elasticity of the skin and reduce wrinkles, containing Euterpe oleracea (acai palm), Citrus aurantiifolia (lime), rosehip and extract of Hibiscus syriacusas flower as active ingredients.
Un objectif de la présente invention est de proposer une alternative à de tels extraits et compositions cosmétiques.One objective of the present invention is to provide an alternative to such extracts and cosmetic compositions.
En effet, il existe un besoin fort et constant pour des compositions cosmétiques efficaces comprenant des actifs naturels en lieu et place de composés chimiques de synthèse.Indeed, there is a strong and constant need for effective cosmetic compositions comprising natural active agents instead of synthetic chemical compounds.
Description de l’inventionDescription of the invention
Cet objectif est atteint grâce à l’invention qui concerne un principe actif comprenant un extrait deFagopyrum esculentum(ouPolygonum fagopyrum) stimulant la synthèse d’élastine par les fibroblastes du derme.This objective is achieved thanks to the invention which relates to an active principle comprising an extract of Fagopyrum esculentum (or Polygonum fagopyrum ) stimulating the synthesis of elastin by the fibroblasts of the dermis.
Les inventeurs ont en effet découvert que des extraits deFagopyrum esculentumont une action sur certains gènes présents dans les fibroblastes du derme humain, impliqués dans la synthèse de l’élastine.The inventors have in fact discovered that extracts of Fagopyrum esculentum have an action on certain genes present in the fibroblasts of the human dermis, involved in the synthesis of elastin.
On notera qu’il est connu de l’art antérieur que certains extraits deFagopyrum esculentumpermettent d’inhiber la lipogenèse, c’est à dire le processus de synthèse des lipides, et notamment celle des triglycérides, se produisant au niveau des adipocytes du derme humain. Il est également connu que de tels extraits peuvent aussi stimuler la lipolyse, c’est-à-dire la dégradation de ces triglycérides. Des compositions cosmétiques contenant de tels extraits ont donc été fabriquées et commercialisées pour des effets sur la peau exploitant ces actions sur la lipogenèse et sur la lipolyse. Ainsi, on connaît des compositions cosmétiques renfermant de tels extraits et ayant pour effet, grâce à une application topique régulière sur la peau, d’affiner la silhouette. On connaît également d’autres compositions cosmétiques renfermant de tels extraits ayant pour effet, grâce à une application topique régulière sous les yeux, de réduire les poches graisseuses pouvant être présentes sous les yeux.It will be noted that it is known from the prior art that certain extracts of Fagopyrum esculentum make it possible to inhibit lipogenesis, that is to say the process of synthesis of lipids, and in particular that of triglycerides, occurring at the level of the adipocytes of the human dermis. It is also known that such extracts can also stimulate lipolysis, that is to say the degradation of these triglycerides. Cosmetic compositions containing such extracts have therefore been manufactured and marketed for effects on the skin exploiting these actions on lipogenesis and on lipolysis. Thus, cosmetic compositions containing such extracts and having the effect, thanks to regular topical application to the skin, of refining the silhouette are known. Other cosmetic compositions containing such extracts are also known which have the effect, thanks to regular topical application under the eyes, of reducing the fatty pockets which may be present under the eyes.
Par contre, à la connaissance de la Demanderesse, il n’avait jamais été mis en lumière que des extraits deFagopyrum esculentumpouvaient agir sur les fibroblastes du derme en stimulant l’expression de gènes impliqués dans la synthèse de l’élastine.On the other hand, to the knowledge of the Applicant, it had never been brought to light that extracts of Fagopyrum esculentum could act on the fibroblasts of the dermis by stimulating the expression of genes involved in the synthesis of elastin.
Également, il a été découvert qu’un tel extrait deFagopyrum esculentumpermet de stimuler l’expression de certains gènes impliqués dans la fonction barrière de la peau, notamment un gène codant pour une enzyme impliquée dans la synthèse de l’acide hyaluronique, et donc de contribuer à renforcer cette fonction. La fonction barrière de la peau a un rôle de protection de l’organisme contre les agressions physiques, tels que le stress mécanique, les changements de température, ou encore les UV, également contre les agressions chimiques, tels que les produits toxiques et les allergènes, et encore contre les agents infectieux. Elle dépend de l’état de la couche cornée de la peau, qui constitue une barrière hydrique partiellement perméable.Also, it has been discovered that such an extract of Fagopyrum esculentum makes it possible to stimulate the expression of certain genes involved in the barrier function of the skin, in particular a gene coding for an enzyme involved in the synthesis of hyaluronic acid, and therefore help to strengthen this function. The barrier function of the skin has a role in protecting the body against physical attacks, such as mechanical stress, temperature changes, or even UV rays, also against chemical attacks, such as toxic products and allergens , and again against infectious agents. It depends on the state of the stratum corneum of the skin, which constitutes a partially permeable water barrier.
L’extrait selon l’invention permet également, outre son rôle sur la stimulation de la synthèse de l’élastine, de réduire la perte en eau de la peau, et donc de pallier à la déshydratation de celle-ci.The extract according to the invention also makes it possible, in addition to its role in stimulating the synthesis of elastin, to reduce the loss of water from the skin, and therefore to compensate for the dehydration of the latter.
Il a aussi été découvert qu’un tel extrait deFagopyrum esculentumpermet de stimuler l’expression de certains gènes impliqués dans la synthèse de créatine et donc de stimuler la synthèse de créatine par les cellules de la peau. La créatine, dérivé d’acide aminé naturel, est présente principalement dans les fibres musculaires et le cerveau, mais elle est également présente dans la peau. Elle joue un rôle important dans l’apport d’énergie aux cellules, en maintenant élevées les fonctions vitales des cellules, les mécanismes cellulaires impliqués dans la réparation et les processus de défense, et dans la synthèse de biomolécules importantes, tel que le collagène.It has also been discovered that such an extract of Fagopyrum esculentum makes it possible to stimulate the expression of certain genes involved in the synthesis of creatine and therefore to stimulate the synthesis of creatine by the cells of the skin. Creatine, a natural amino acid derivative, is present mainly in muscle fibers and the brain, but it is also present in the skin. It plays an important role in providing energy to cells, maintaining high vital cell functions, cellular mechanisms involved in repair and defense processes, and in the synthesis of important biomolecules, such as collagen.
Ainsi l’invention repose sur une approche originale ayant consisté à étudier l’effet de l’application topique d’extraits deFagopyrum esculentum sur l’expression de gènes impliqués dans la synthèse de l’élastine par les fibroblastes du derme, ainsi que certains gènes impliqués dans la synthèse de la créatine par la peau et ceux impliqués dans la préservation de la fonction barrière de celle-ci.Thus the invention is based on an original approach having consisted in studying the effect of the topical application of extracts ofFagopyrum esculentum on the expression of genes involved in the synthesis of elastin by dermal fibroblasts, as well as certain genes involved in the synthesis of creatine by the skin and those involved in the preservation of its barrier function.
Ainsi, un premier objet concerne un principe actif comprenant un extrait deFagopyrum esculentumstimulant la synthèse d’élastine par les fibroblastes du derme.Thus, a first object relates to an active principle comprising an extract of Fagopyrum esculentum stimulating the synthesis of elastin by the fibroblasts of the dermis.
Selon un mode de réalisation, cet extrait deFagopyrum esculentumest un extrait obtenu par extraction au dioxyde de carbone (CO2) supercritique.According to one embodiment, this extract of Fagopyrum esculentum is an extract obtained by extraction with supercritical carbon dioxide (CO 2 ).
Selon un autre mode de réalisation, cet extrait deFagopyrum esculentumest un extrait huileux.According to another embodiment, this extract of Fagopyrum esculentum is an oily extract.
Selon l’invention, le principe actif stimule préférentiellement l’expression du gène ELN codant pour l’élastine.According to the invention, the active principle preferentially stimulates the expression of the ELN gene coding for elastin.
Selon l’invention, le principe actif stimule préférentiellement, de plus, l’expression du gène HAS2, codant pour l’enzyme Hyaluronic acid synthase 2, impliquée dans la synthèse de l’acide hyaluronique.According to the invention, the active ingredient preferentially stimulates, in addition, the expression of the HAS2 gene, coding for the enzyme Hyaluronic acid synthase 2, involved in the synthesis of hyaluronic acid.
Selon encore un autre mode de réalisation, ce principe actif stimule préférentiellement, de plus, l’expression de gènes des fibroblastes du derme, choisis parmi GATM codant pour la glycine amidinotransférase et GAMT codant pour la guanidinoacétate N-méthyltransférase, impliquées dans la synthèse de la créatine.According to yet another embodiment, this active ingredient preferentially stimulates, in addition, the expression of genes of dermal fibroblasts, chosen from GATM coding for glycine amidinotransferase and GAMT coding for guanidinoacetate N-methyltransferase, involved in the synthesis of creatine.
Un deuxième objet concerne une composition cosmétique pour application topique comprenant un principe actif tel que décrit précédemment, ainsi qu’un milieu physiologiquement acceptable, cette composition étant destinée à améliorer l’élasticité de la peau.A second subject relates to a cosmetic composition for topical application comprising an active principle as described previously, as well as a physiologically acceptable medium, this composition being intended to improve the elasticity of the skin.
Selon un mode de réalisation, l’extrait deFagopyrum esculentumest présent à une concentration comprise entre 0,01% et 10% en poids par rapport au poids total de la composition, de préférence entre 0,1% et 1% en poids par rapport au poids total de la composition.According to one embodiment, the extract of Fagopyrum esculentum is present at a concentration of between 0.01% and 10% by weight relative to the total weight of the composition, preferably between 0.1% and 1% by weight per relative to the total weight of the composition.
Un troisième objet concerne l’utilisation d’un principe actif tel que décrit précédemment en tant qu’ingrédient actif cosmétique.A third object concerns the use of an active principle as described above as a cosmetic active ingredient.
Un quatrième objet concerne l’utilisation d’une composition telle que décrite précédemment en tant que composition cosmétique destinée à être appliquée sur la peau saine, et notamment sur le contour des yeux.A fourth object concerns the use of a composition as described above as a cosmetic composition intended to be applied to healthy skin, and in particular to the eye contour.
Claims (11)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR2110990A FR3128122B1 (en) | 2021-10-15 | 2021-10-15 | Active ingredient comprising an extract of Fagopyrum escule n tum acting on the elasticity of the skin, cosmetic compositions comprising it and corresponding uses. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR2110990A FR3128122B1 (en) | 2021-10-15 | 2021-10-15 | Active ingredient comprising an extract of Fagopyrum escule n tum acting on the elasticity of the skin, cosmetic compositions comprising it and corresponding uses. |
| FR2110990 | 2021-10-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR3128122A1 true FR3128122A1 (en) | 2023-04-21 |
| FR3128122B1 FR3128122B1 (en) | 2024-10-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR2110990A Active FR3128122B1 (en) | 2021-10-15 | 2021-10-15 | Active ingredient comprising an extract of Fagopyrum escule n tum acting on the elasticity of the skin, cosmetic compositions comprising it and corresponding uses. |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR3128122B1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2358158A1 (en) * | 2001-10-02 | 2003-04-02 | Fytokem Products Inc. | Elastase inhibitors |
| KR20070014412A (en) * | 2005-07-28 | 2007-02-01 | 재단법인춘천바이오산업진흥원 | Functional cosmetic composition comprising extract of fagopyrum esculentum |
-
2021
- 2021-10-15 FR FR2110990A patent/FR3128122B1/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2358158A1 (en) * | 2001-10-02 | 2003-04-02 | Fytokem Products Inc. | Elastase inhibitors |
| KR20070014412A (en) * | 2005-07-28 | 2007-02-01 | 재단법인춘천바이오산업진흥원 | Functional cosmetic composition comprising extract of fagopyrum esculentum |
Non-Patent Citations (5)
| Title |
|---|
| ANONYMOUS: "Buckwheat wax : anti-puffiness, face contouring", CODIF RECHERCHE ET NATURE, 1 September 2007 (2007-09-01), XP055934827, Retrieved from the Internet <URL:https://www.codif-tn.com/wp-content/uploads/2016/02/BUCKWHEAT-WAX-BROCHURE-GB.pdf> * |
| ANONYMOUS: "RAW MATERIAL IDENTIFICATION 1. TRADE NAME : CIRE DE BLE NOIR / BUCKWHEAT WAX - ALG114 Item: Plant concentrate - Cosmetic application", CODIF TECHNOLOGIE NATURELLE, 4 May 2016 (2016-05-04), XP055934828, Retrieved from the Internet <URL:https://www.codif-tn.com/wp-content/uploads/2016/02/CIRE-DE-BLE-NOIR-FICHE-TECH-1.pdf> * |
| DATABASE GNPD [online] MINTEL; 21 July 2020 (2020-07-21), ANONYMOUS: "Grapefruit Body Firming Cream", XP055935000, retrieved from https://www.gnpd.com/sinatra/recordpage/7977993/ Database accession no. 7977993 * |
| DATABASE GNPD [online] MINTEL; 3 April 2020 (2020-04-03), ANONYMOUS: "Anti-Pollution Energizing Super Hydrating Youth Protector", XP055935003, retrieved from https://www.gnpd.com/sinatra/recordpage/7448013/ Database accession no. 7448013 * |
| DATABASE GNPD [online] MINTEL; 6 November 2020 (2020-11-06), ANONYMOUS: "Precious Lifting Concentrate", XP055934998, retrieved from https://www.gnpd.com/sinatra/recordpage/8245733/ Database accession no. 8245733 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR3128122B1 (en) | 2024-10-18 |
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